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Abstract

▪ Abstract 

The Adenomatous Polyposis coli (APC) gene is mutated or lost in most colon cancers, and the APC protein has emerged as a multifunctional protein that is not only involved in the Wnt-regulated degradation of β-catenin, but also regulates cytoskeletal proteins and thus plays a role in cell migration, cell adhesion, and mitosis. The gut epithelium is uniquely dependent on an intricate balance between a number of fundamental cellular processes including migration, differentiation, adhesion, apoptosis, and mitosis. In this review, I discuss the molecular mechanisms that govern the various functions of APC and their relationship to the role of APC in colon cancer.

Keyword(s): cancercoloncytoskeletonmigrationWnt
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/content/journals/10.1146/annurev.cellbio.20.012103.094541
2005-02-10
2024-06-16
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  • Article Type: Review Article
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