1932

Abstract

Abstract

The microenvironment influences gene expression so that the behavior of a cell is largely determined by its interactions with the extracellular matrix, neighboring cells, and soluble local and systemic cues. We describe the essential roles of context and organ structure in directing mammary gland development and differentiated function and in determining the response to oncogenic insults, including mutations. We expand on the concept of “dynamic reciprocity” to present an integrated view of development, cancer, and aging and posit that genes are like the keys on a piano: Although they are essential, it is the context that makes the music.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.cellbio.22.010305.104315
2006-11-10
2024-07-25
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.cellbio.22.010305.104315
Loading
/content/journals/10.1146/annurev.cellbio.22.010305.104315
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error