1932

Abstract

Progress in aging research is now rapid, and surprisingly, studies in a single-celled eukaryote are a driving force. The genetic modulators of replicative life span in yeast are being identified, the molecular events that accompany aging are being discovered, and the extent to which longevity pathways are conserved between yeast and multicellular eukaryotes is being tested. In this review, we provide a brief retrospective view on the development of yeast as a model for aging and then turn to recent discoveries that have pushed aging research into novel directions and also linked aging in yeast to well-developed hypotheses in mammals. Although the question of what causes aging still cannot be answered definitively, that day may be rapidly approaching.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.cellbio.23.090506.123509
2008-11-10
2024-06-22
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.cellbio.23.090506.123509
Loading
/content/journals/10.1146/annurev.cellbio.23.090506.123509
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error