1932

Abstract

Abstract

Studies in have revealed paradigms for regulating gene expression through chromatin structure, including mechanisms of gene activation and silencing. Regulation occurs at the level of individual genes, chromosomal domains, and entire chromosomes. The chromatin state is dynamic, allowing for changes in gene expression in response to cellular signals and/or environmental cues. Changes in chromatin result from the action of ATP-dependent chromatin-remodeling complexes, reversible epigenetic histone modifications, and the incorporation of histone variants. Many of the chromatin-based transcriptional regulatory mechanisms discovered in are evolutionarily conserved and therefore serve as a foundation for studies in other organisms.

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/content/journals/10.1146/annurev.ento.51.110104.151007
2007-01-07
2024-04-16
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  • Article Type: Review Article
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