1932

Abstract

The anterior-posterior axis of the zygote forms shortly after fertilization when the sperm pronucleus and its associated centrosomal asters provide a cue that establishes the anterior-posterior (AP) body axis. In response to this cue, the microfilament cytoskeleton polarizes the distribution of a group of widely conserved, cortically localized regulators called the PAR proteins, which are required for the first mitotic division to be asymmetric. These asymmetries include a posterior displacement of the first mitotic spindle and the differential segregation of cell-fate determinants to the anterior and posterior daughters produced by the first cleavage of the zygote. Here we review recent advances in our understanding of the mechanisms that polarize the one-cell zygote to generate an AP axis of asymmetry.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.genet.37.110801.142443
2003-12-01
2024-06-23
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.genet.37.110801.142443
Loading
/content/journals/10.1146/annurev.genet.37.110801.142443
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error