1932

Abstract

▪ Abstract 

The process of homologous recombination promotes error-free repair of double-strand breaks and is essential for meiosis. Central to the process of homologous recombination are the group genes (, , , , , , , , , and ), most of which were identified by their requirement for the repair of ionizing radiation-induced DNA damage in . The Rad52 group proteins are highly conserved among eukaryotes. Recent studies showing defects in homologous recombination and double-strand break repair in several human cancer-prone syndromes have emphasized the importance of this repair pathway in maintaining genome integrity. Herein, we review recent genetic, biochemical, and structural analyses of the genes and proteins involved in recombination.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.genet.38.072902.091500
2004-12-15
2024-04-15
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.genet.38.072902.091500
Loading
/content/journals/10.1146/annurev.genet.38.072902.091500
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error