1932

Abstract

Abstract

uses novel regulatory mechanisms in controlling expression of its genes of tryptophan synthesis and transport. These mechanisms respond to changes in the intracellular concentrations of free tryptophan and uncharged tRNATrp. The major protein that regulates tryptophan biosynthesis is the tryptophan-activated RNA-binding attenuation protein, TRAP. TRAP is a ring-shaped molecule composed of 11 identical subunits. Active TRAP binds to unique RNA segments containing multiple trinucleotide (NAG) repeats. Binding regulates both transcription termination and translation in the operon, and translation of other coding regions relevant to tryptophan metabolism. When there is a deficiency of charged tRNATrp, forms an anti-TRAP protein, AT. AT antagonizes TRAP function, thereby increasing expression of all the genes regulated by TRAP. Thus and respond to identical regulatory signals, tryptophan and uncharged tRNATrp, yet they employ different mechanisms in regulating gene expression.

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/content/journals/10.1146/annurev.genet.39.073003.093745
2005-12-15
2024-06-24
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  • Article Type: Review Article
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