1932

Abstract

Abstract

Germline stem cells (GSCs), which can self-renew and generate differentiated progeny, are unique stem cells in that they are solely dedicated to reproduction and transmit genetic information from generation to generation. Through the use of genetic techniques in , and mouse, exciting progress has been made in understanding molecular mechanisms underlying interactions between stem cells and niches. The knowledge gained from studying GSCs has provided an intellectual framework for defining niches and molecular regulatory mechanisms for other adult stem cells. In this review, we summarize recent progress and discuss conserved mechanisms underlying GSC self-renewal and differentiation by comparing three GSC systems. Because GSCs and other adult stem cells share “stemness,” we hope this review will help define fundamental principles of stem cell regulation and provide further guidance for future studies of other adult stem cells.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.genet.39.073003.105855
2005-12-15
2024-10-05
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.genet.39.073003.105855
Loading
/content/journals/10.1146/annurev.genet.39.073003.105855
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error