1932

Abstract

Genetic interactions influencing a phenotype of interest can be identified systematically using libraries of genetic tools that perturb biological systems in a defined manner. Systematic screens conducted in the yeast have identified thousands of genetic interactions and provided insight into the global structure of biological networks. Techniques enabling systematic genetic interaction mapping have been extended to other single-celled organisms, the bacteria and the yeast , opening the way to comparative investigations of interaction networks. Genetic interaction screens in , , and mammalian models are helping to improve our understanding of metazoan-specific signaling pathways. Together, our emerging knowledge of the genetic wiring diagrams of eukaryotic and prokaryotic cells is providing a new understanding of the relationship between genotype and phenotype.

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/content/journals/10.1146/annurev.genet.39.073003.114751
2009-12-01
2024-06-17
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  • Article Type: Review Article
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