1932

Abstract

The dynamic range of a bacterial species’ natural environment is reflected in the complexity of its systems that control cell cycle progression and its range of adaptive responses. We discuss the genetic network and integrated three-dimensional sensor/response systems that regulate the cell cycle and asymmetric cell division in the bacterium . The cell cycle control circuitry is tied closely to chromosome replication and morphogenesis by multiple feedback pathways from the modular functions that implement the cell cycle. The sophistication of the genetic regulatory circuits and the elegant integration of temporally controlled transcription and protein synthesis with spatially dynamic phosphosignaling and proteolysis pathways, and epigenetic regulatory mechanisms, form a remarkably robust living system.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.genet.41.110306.130346
2007-12-01
2024-04-17
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.genet.41.110306.130346
Loading
/content/journals/10.1146/annurev.genet.41.110306.130346
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error