1932

Abstract

▪ Abstract 

The availability of complete genome sequences and the wealth of large-scale biological data sets now provide an unprecedented opportunity to elucidate the genetic basis of rare and common human diseases. Here we review some of the emerging genomics technologies and data resources that can be used to infer gene function to prioritize candidate genes. We then describe some computational strategies for integrating these large-scale data sets to provide more faithful descriptions of gene function, and how such approaches have recently been applied to discover genes underlying Mendelian disorders. Finally, we discuss future prospects and challenges for using integrative genomics to systematically discover not only single genes but also entire gene networks that underlie and modify human disease.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.genom.6.080604.162234
2005-09-22
2024-06-14
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.genom.6.080604.162234
Loading
/content/journals/10.1146/annurev.genom.6.080604.162234
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error