1932

Abstract

Protein tyrosine phosphatases (PTPs) are important regulators of many cellular functions and a growing number of PTPs have been implicated in human disease conditions, such as developmental defects, neoplastic disorders, and immunodeficiency. Here, we review the involvement of PTPs in human autoimmunity. The leading examples include the allelic variant of the lymphoid tyrosine phosphatase (), which is associated with multiple autoimmune diseases, and mutations that affect the exon-intron splicing of CD45 (). We also find it likely that additional PTPs are involved in susceptibility to autoimmune and inflammatory diseases. Finally, we discuss the possibility that PTPs regulating the immune system may serve as therapeutic targets.

Keyword(s): CD45LYPPTPN22
Loading

Article metrics loading...

/content/journals/10.1146/annurev.immunol.26.021607.090418
2008-04-23
2024-04-13
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.immunol.26.021607.090418
Loading
/content/journals/10.1146/annurev.immunol.26.021607.090418
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error