1932

Abstract

Synaptic vesicle exocytosis occurs in consecutive steps: docking, which specifically attaches vesicles to the active zone; priming, which makes the vesicles competent for Ca2+-triggered release and may involve a partial fusion reaction; and the final Ca2+-regulated step that completes fusion. Recent evidence suggests that the critical regulation of the last step in the reaction is mediated by two proteins with opposite actions: synaptotagmin, a Ca2+-binding protein that is essential for Ca2+-triggered release and probably serves as the Ca2+-sensor in fusion, and rab3, which limits the number of vesicles that can be fused as a function of Ca2+ in order to allow a temporally limited, repeatable signal.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.neuro.21.1.75
1998-03-01
2024-10-05
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.neuro.21.1.75
Loading
/content/journals/10.1146/annurev.neuro.21.1.75
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error