1932

Abstract

The neurological mutant mouse has played a critical role in the evolution of our understanding of normal brain development. From the earliest neuroanatomic studies of , it was anticipated that the characterization of the gene responsible would elucidate important molecular and cellular principles governing cell positioning and the formation of synaptic circuits in the developing brain. Indeed, the identification of has challenged many of our previous notions and has led to a new vision of the events involved in the migration of neurons. Several neuronal populations throughout the brain secrete Reelin, which binds to transmembrane receptors located on adjacent cells triggering a tyrosine kinase cascade. This allows neurons to complete migration and adopt their ultimate positions in laminar structures in the central nervous system. Recent studies have also suggested a role for the Reelin pathway in axonal branching, synaptogenesis, and pathology underlying neurodegeneration.

Keyword(s): brainDab1migrationreelertyrosine kinase
Loading

Article metrics loading...

/content/journals/10.1146/annurev.neuro.24.1.1005
2001-03-01
2024-10-05
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.neuro.24.1.1005
Loading
/content/journals/10.1146/annurev.neuro.24.1.1005
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error