1932

Abstract

Activity-dependent changes in synaptic function are believed to underlie the formation of memories. Two prominent examples are long-term potentiation (LTP) and long-term depression (LTD), whose mechanisms have been the subject of considerable scrutiny over the past few decades. Here we review the growing literature that supports a critical role for AMPA receptor trafficking in LTP and LTD, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins. While much work remains to understand the molecular basis for synaptic plasticity, recent results on AMPA receptor trafficking provide a clear conceptual framework for future studies.

Keyword(s): excitatoryLTDLTPmemorytransmission
Loading

Article metrics loading...

/content/journals/10.1146/annurev.neuro.25.112701.142758
2002-03-01
2024-12-05
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.neuro.25.112701.142758
Loading
/content/journals/10.1146/annurev.neuro.25.112701.142758
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error