1932

Abstract

Hydrogen bonds are a key feature of chemical structure and reactivity. Recently there has been much interest in a special class of hydrogen bonds called “strong” or “low-barrier” and characterized by great strength, short distances, a low or vanishing barrier to hydrogen transfer, and distinctive features in the NMR spectrum. Although the energy of an ordinary hydrogen bond is ca 5 kcal mol−1, the strength of these hydrogen bonds may be ≥10 kcal mol−1. The properties of these hydrogen bonds have been investigated by many experimental techniques, as well as by calculation and by correlations among those properties. Although it has been proposed that strong, short, low-barrier hydrogen bonds are important in enzymatic reactions, it is concluded that the evidence for them in small molecules and in biomolecules is inconclusive.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.physchem.48.1.511
1997-10-01
2024-06-17
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.physchem.48.1.511
Loading
/content/journals/10.1146/annurev.physchem.48.1.511
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error