1932

Abstract

The functional impact of ion channels in vascular endothelial cells (ECs) is still a matter of controversy. This review describes different types of ion channels in ECs and their role in electrogenesis, Ca2+ signaling, vessel permeability, cell-cell communication, mechano-sensor functions, and pH and volume regulation. One major function of ion channels in ECs is the control of Ca2+ influx either by a direct modulation of the Ca2+ influx pathway or by indirect modulation of K+ and Cl channels, thereby clamping the membrane at a sufficiently negative potential to provide the necessary driving force for a sustained Ca2+ influx. We discuss various mechanisms of Ca2+ influx stimulation: those that activate nonselective, Ca2+-permeable cation channels or those that activate Ca2+-selective channels, exclusively or partially operated by the filling state of intracellular Ca2+ stores. We also describe the role of various Ca2+- and shear stress-activated K+ channels and different types of Cl channels for the regulation of the membrane potential.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.physiol.59.1.145
1997-03-01
2024-06-12
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.physiol.59.1.145
Loading
/content/journals/10.1146/annurev.physiol.59.1.145
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error