1932

Abstract

Secreted by the heart, more specifically by atrial cardiomyocytes under normal conditions but also by ventricular myocytes during cardiac hypertrophy, natriuretic peptides are now considered important hormones in the control of blood pressure and salt and water excretion. Studies on natriuretic peptide secretagogues and their mechanisms of action have been complicated by hemodynamic changes and contractions to which the atria are constantly subjected. It now appears that atrial stretch through mechano-sensitive ion channels, adrenergic stimulation via α-adrenergic receptors, and endothelin via its ET receptor subtype are major triggering agents of natriuretic peptide release. With several other stimuli, such as angiotensin II and β-adrenergic agents, modulation of natriuretic peptide release appears to be linked to local generation of prostaglandins. In all cases, intracellular calcium homeostasis, controlled by several ion channels, is considered a key element in the regulation of natriuretic peptide secretion.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.physiol.61.1.193
1999-03-01
2024-12-13
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.physiol.61.1.193
Loading
/content/journals/10.1146/annurev.physiol.61.1.193
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error