1932

Abstract

There is increasing evidence suggesting that formation of the tracheobronchial tree and alveoli results from heterogeneity of the epithelial-mesenchymal interactions along the developing respiratory tract. Recent genetic data support this idea and show that this heterogeneity is likely the result of activation of distinct networks of signaling molecules along the proximal-distal axis. Among these signals, fibroblast growth factors, retinoids, Sonic hedgehog, and transforming growth factors appear to play prominent roles. We discuss how these and other pattern regulators may be involved in initiation, branching, and differentiation of the respiratory system.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.physiol.63.1.471
2001-03-01
2024-04-19
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.physiol.63.1.471
Loading
/content/journals/10.1146/annurev.physiol.63.1.471
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error