1932

Abstract

▪ Abstract 

Classical experiments in embryology have shown that normal growth, morphogenetic patterning, and cellular differentiation in the developing lung depend on interactive signaling between the endodermal epithelium and mesenchyme derived from splanchnic mesoderm. These interactions are mediated by a myriad of diffusible factors that are precisely regulated in their temporal and spatial expression. In this review we first describe factors regulating formation of the embryonic foregut. We then discuss the experiments demonstrating the importance of tissue interactions in lung patterning and differentiation. Finally, we detail the roles that a few key signaling systems—fibroblast growth factors and their receptors, and Gli genes, Wnt genes and β, and —play as mediators of epithelial-mesenchymal interactions in the developing lung.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.physiol.66.032102.135749
2004-03-17
2024-06-17
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.physiol.66.032102.135749
Loading
/content/journals/10.1146/annurev.physiol.66.032102.135749
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error