▪ Abstract 

In many species the pancreatic duct epithelium secretes HCO ions at a concentration of around 140 mM by a mechanism that is only partially understood. We know that HCO uptake at the basolateral membrane is achieved by Na+-HCO cotransport and also by a H+-ATPase and Na+/H+ exchanger operating together with carbonic anhydrase. At the apical membrane, the secretion of moderate concentrations of HCO can be explained by the parallel activity of a Cl/HCO exchanger and a Cl conductance, either the cystic fibrosis transmembrane conductance regulator (CFTR) or a Ca2+-activated Cl channel (CaCC). However, the sustained secretion of HCO into a HCO-rich luminal fluid cannot be explained by conventional Cl/HCO exchange. HCO efflux across the apical membrane is an electrogenic process that is facilitated by the depletion of intracellular Cl, but it remains to be seen whether it is mediated predominantly by CFTR or by an electrogenic SLC26 anion exchanger.


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  • Article Type: Review Article
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