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Annual Review of Chemical and Biomolecular Engineering

Volume 11, 2020

How Do Cells Adapt? Stories Told in Landscapes

Abstract

Cells adapt to changing environments. Perturb a cell and it returns to a point of homeostasis. Perturb a population and it evolves toward a fitness peak. We review quantitative models of the forces of adaptation and their visualizations on landscapes. While some adaptations result from single mutations or few-gene effects, others are more cooperative, more delocalized in the genome, and more universal and physical. For example, homeostasis and evolution depend on protein folding and aggregation, energy and protein production, protein diffusion, molecular motor speeds and efficiencies, and protein expression levels. Models provide a way to learn about the fitness of cells and cell populations by making and testing hypotheses.

Keyword(s): adaptation, evolution, fitness, homeostasis, landscape
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2020-06-07
2024-04-26
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How Do Cells Adapt? Stories Told in Landscapes
Annual Review of Chemical and Biomolecular Engineering 11, 155 (2020); https://doi.org/10.1146/annurev-chembioeng-011720-103410
/content/journals/10.1146/annurev-chembioeng-011720-103410
/content/journals/10.1146/annurev-chembioeng-011720-103410
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