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Annual Review of Analytical Chemistry

Volume 12, 2019

Well-Defined Materials for High-Performance Chromatographic Separation

Abstract

Chromatographic separation has been widely applied in various fields, such as chemical engineering, precision medicine, energy, and biology. Because chromatographic separation is based on differential partitioning between the mobile phase and stationary phase and affected by band dispersion and mass transfer resistance from these two phases, the materials used as the stationary phase play a decisive role in separation performance. In this review, we discuss the design of separation materials to achieve the separation with high efficiency and high resolution and highlight the well-defined materials with uniform pore structure and unique properties. The achievements, recent developments, challenges, and future trends of such materials are discussed. Furthermore, the surface functionalization of separation ma-terials for further improvement of separation performance is reviewed. Finally, future research directions and the challenges of chromatographic separation are presented.

Keyword(s): colloidal crystals, core–shell particles, metal-organic/covalent organic frameworks, monoliths, periodic mesoporous organosilicas, separation
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/content/journals/10.1146/annurev-anchem-061318-114854
2019-06-12
2024-05-23
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/content/journals/10.1146/annurev-anchem-061318-114854
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Well-Defined Materials for High-Performance Chromatographic Separation
Annual Review of Analytical Chemistry 12, 451 (2019); https://doi.org/10.1146/annurev-anchem-061318-114854
/content/journals/10.1146/annurev-anchem-061318-114854
/content/journals/10.1146/annurev-anchem-061318-114854
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