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Annual Review of Analytical Chemistry

Volume 14, 2021

The Role of Raman Spectroscopy Within Quantitative Metabolomics

Abstract

Ninety-four years have passed since the discovery of the Raman effect, and there are currently more than 25 different types of Raman-based techniques. The past two decades have witnessed the blossoming of Raman spectroscopy as a powerful physicochemical technique with broad applications within the life sciences. In this review, we critique the use of Raman spectroscopy as a tool for quantitative metabolomics. We overview recent developments of Raman spectroscopy for identification and quantification of disease biomarkers in liquid biopsies, with a focus on the recent advances within surface-enhanced Raman scattering–based methods. Ultimately, we discuss the applications of imaging modalities based on Raman scattering as label-free methods to study the abundance and distribution of biomolecules in cells and tissues, including mammalian, algal, and bacterial cells.

Keyword(s): CARS, coherent anti-Stokes Raman spectroscopy, metabolomics, Raman spectroscopy, SERS, SORS, spatially offset Raman spectroscopy, SRS, stimulated Raman spectroscopy, surface-enhanced Raman scattering
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/content/journals/10.1146/annurev-anchem-091420-092323
2021-07-27
2025-04-22
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/content/journals/10.1146/annurev-anchem-091420-092323
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The Role of Raman Spectroscopy Within Quantitative Metabolomics
Annual Review of Analytical Chemistry 14, 323 (2021); https://doi.org/10.1146/annurev-anchem-091420-092323
/content/journals/10.1146/annurev-anchem-091420-092323
/content/journals/10.1146/annurev-anchem-091420-092323
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