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Annual Review of Biomedical Engineering

Volume 24, 2022

Direct Cardiac Compression Devices to Augment Heart Biomechanics and Function

Abstract

The treatment of end-stage heart failure has evolved substantially with advances in medical treatment, cardiac transplantation, and mechanical circulatory support (MCS) devices such as left ventricular assist devices and total artificial hearts. However, current MCS devices are inherently blood contacting and can lead to potential complications including pump thrombosis, hemorrhage, stroke, and hemolysis. Attempts to address these issues and avoid blood contact led to the concept of compressing the failing heart from the epicardial surface and the design of direct cardiac compression (DCC) devices. We review the fundamental concepts related to DCC, present the foundational devices and recent devices in the research and commercialization stages, and discuss the milestones required for clinical translation and adoption of this technology.

Keyword(s): cardiac assist devices, cardiac biomechanics, direct cardiac compression, heart failure, mechanical circulatory support, soft robotics
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2022-06-06
2024-05-12
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/content/journals/10.1146/annurev-bioeng-110220-025309
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Direct Cardiac Compression Devices to Augment Heart Biomechanics and Function
Annual Review of Biomedical Engineering 24, 137 (2022); https://doi.org/10.1146/annurev-bioeng-110220-025309
/content/journals/10.1146/annurev-bioeng-110220-025309
/content/journals/10.1146/annurev-bioeng-110220-025309
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