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Annual Review of Biophysics

Volume 53, 2024

Single-Cell Mechanics: Structural Determinants and Functional Relevance

  • Marta Urbanska1,2,3 and Jochen Guck1,2,4
  • 1Max Planck Institute for the Science of Light, Erlangen, Germany; email: [email protected], [email protected] 2Max-Planck-Zentrum für Physik und Medizin, Erlangen, Germany 3Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK 4Department of Physics, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany
  • Vol. 53:367-395 (Volume publication date July 2024)
  • First published as a Review in Advance on February 21, 2024
  • Copyright © 2024 by the author(s).
    This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See credit lines of images or other third-party material in this article for license information.

Abstract

The mechanical phenotype of a cell determines its ability to deform under force and is therefore relevant to cellular functions that require changes in cell shape, such as migration or circulation through the microvasculature. On the practical level, the mechanical phenotype can be used as a global readout of the cell's functional state, a marker for disease diagnostics, or an input for tissue modeling. We focus our review on the current knowledge of structural components that contribute to the determination of the cellular mechanical properties and highlight the physiological processes in which the mechanical phenotype of the cells is of critical relevance. The ongoing efforts to understand how to efficiently measure and control the mechanical properties of cells will define the progress in the field and drive mechanical phenotyping toward clinical applications.

Keyword(s): cell mechanics, circulation, cytoskeleton, mechanical phenotyping, migration
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2024-07-16
2025-06-19
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/content/journals/10.1146/annurev-biophys-030822-030629
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Single-Cell Mechanics: Structural Determinants and Functional Relevance
Annual Review of Biophysics 53, 367 (2024); https://doi.org/10.1146/annurev-biophys-030822-030629
/content/journals/10.1146/annurev-biophys-030822-030629
/content/journals/10.1146/annurev-biophys-030822-030629
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