1932

Abstract

All aspects of DNA metabolism—including transcription, replication, and repair—involve motor enzymes that move along genomic DNA. These processes must all take place on chromosomes that are occupied by a large number of other proteins. However, very little is known regarding how nucleic acid motor proteins move along the crowded DNA substrates that are likely to exist in physiological settings. This review summarizes recent progress in understanding how DNA-binding motor proteins respond to the presence of other proteins that lie in their paths. We highlight recent single-molecule biophysical experiments aimed at addressing this question, with an emphasis placed on analyzing the single-molecule, ensemble biochemical, and in vivo data from a mechanistic perspective.

Loading

Article metrics loading...

/content/journals/10.1146/annurev-biophys-083012-130304
2013-05-06
2024-12-14
Loading full text...

Full text loading...

/content/journals/10.1146/annurev-biophys-083012-130304
Loading
/content/journals/10.1146/annurev-biophys-083012-130304
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error