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Annual Review of Biophysics

Volume 51, 2022

A Life of Biophysics

Abstract

Biophysics is a way of approaching biological problems through numbers, physical laws, models, and quantitative logic. In a long scientific career, I have seen the formation and fruition of the ion channel concept through biophysical study. Marvelous discoveries were made as our instruments evolved from vacuum tubes to transistors; computers evolved from the size of an entire building to a few chips inside our instruments; and genome sequencing, gene expression, and atom-level structural biology became accessible to all laboratories. Science is rewarding and exhilarating.

Keyword(s): autobiography, G-protein-coupled receptors, Hodgkin-Huxley model, ion channel, local anesthetics, membrane proteins, patch clamp
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2022-05-09
2024-05-14
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A Life of Biophysics
Annual Review of Biophysics 51, 1 (2022); https://doi.org/10.1146/annurev-biophys-120121-074034
/content/journals/10.1146/annurev-biophys-120121-074034
/content/journals/10.1146/annurev-biophys-120121-074034
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