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Annual Review of Cell and Developmental Biology

Volume 36, 2020

Processing Temporal Growth Factor Patterns by an Epidermal Growth Factor Receptor Network Dynamically Established in Space

Abstract

The proto-oncogenic epidermal growth factor (EGF) receptor (EGFR) is a tyrosine kinase whose sensitivity and response to growth factor signals that vary over time and space determine cellular behavior within a developing tissue. The molecular reorganization of the receptors on the plasma membrane and the enzyme-kinetic mechanisms of phosphorylation are key determinants that couple growth factor binding to EGFR signaling. To enable signal initiation and termination while simultaneously accounting for suppression of aberrant signaling, a coordinated coupling of EGFR kinase and protein tyrosine phosphatase activity is established through space by vesicular dynamics. The dynamical operation mode of this network enables not only time-varying growth factor sensing but also adaptation of the response depending on cellular context. By connecting spatially coupled enzymatic kinase/phosphatase processes and the corresponding dynamical systems description of the EGFR network, we elaborate on the general principles necessary for processing complex growth factor signals.

Keyword(s): collective computing, nonlinear dynamics, receptor tyrosine kinases, spatial cycles, spatially organized signaling, time-varying growth factors
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/content/journals/10.1146/annurev-cellbio-013020-103810
2020-10-06
2025-05-23
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/content/journals/10.1146/annurev-cellbio-013020-103810
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Processing Temporal Growth Factor Patterns by an Epidermal Growth Factor Receptor Network Dynamically Established in Space
Annual Review of Cell and Developmental Biology 36, 359 (2020); https://doi.org/10.1146/annurev-cellbio-013020-103810
/content/journals/10.1146/annurev-cellbio-013020-103810
/content/journals/10.1146/annurev-cellbio-013020-103810
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