Pediatric Allergic Diseases, Food Allergy, and Oral Tolerance

Literature Cited

1. Abdel-Gadir A, Stephen-Victor E, Gerber GK, Rivas MN, Wang S et al. 2019. Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy. Nat. Med. 25:1164–74
   [Google Scholar]
2. Alberto EJC, Shimojo N, Suzuki Y, Mashimo Y, Arima T et al. 2008. IL-10 gene polymorphism, but not TGF-β1 gene polymorphisms, is associated with food allergy in a Japanese population. Pediatr. Allergy Immunol. 19:8716–21
   [Google Scholar]
3. Altunbulakli C, Reiger M, Neumann AU, Garzorz-Stark N, Fleming M et al. 2018. Relations between epidermal barrier dysregulation and Staphylococcus species–dominated microbiome dysbiosis in patients with atopic dermatitis. J. Allergy Clin. Immunol. 142:1643–47
   [Google Scholar]
4. Arshad SH, Bateman B, Sadeghnejad A, Gant C, Matthews SM 2007. Prevention of allergic disease during childhood by allergen avoidance: the Isle of Wight prevention study. J. Allergy Clin. Immunol. 119:2307–13
   [Google Scholar]
5. Asai Y, Eslami A, van Ginkel CD, Akhabir L, Wan M et al. 2018. Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy. J. Allergy Clin. Immunol. 141:3991–1001
   [Google Scholar]
6. Bager P, Wohlfahrt J, Westergaard T 2008. Caesarean delivery and risk of atopy and allergic disease: meta-analyses. Clin. Exp. Allergy 38:4634–42
   [Google Scholar]
7. Baker SS, Cochran WJ, Greer FR, Heyman MB, Jacobson MS et al. 2000. Hypoallergenic infant formulas. Pediatrics 106:2346–49
   [Google Scholar]
8. Beasley R, Semprini A, Mitchell EA 2015. Risk factors for asthma: Is prevention possible. ? Lancet 386:99981075–85
   [Google Scholar]
9. Bellach J, Schwarz V, Ahrens B, Trendelenburg V, Aksunger O et al. 2017. Randomized placebo-controlled trial of hen's egg consumption for primary prevention in infants. J. Allergy Clin. Immunol. 139:51591–99.e2
   [Google Scholar]
10. Bergmann RL, Diepgen TL, Kuss O, Bergmann KE, Kujat J et al. 2002. Breastfeeding duration is a risk factor for atopic eczema. Clin. Exp. Allergy 32:2205–9
    [Google Scholar]
11. Bisgaard H, Stokholm J, Chawes BL, Vissing NH, Bjarnadottir E et al. 2016. Fish oil–derived fatty acids in pregnancy and wheeze and asthma in offspring. N. Engl. J. Med. 375:262530–39
    [Google Scholar]
12. Botha M, Basera W, Facey-Thomas HE, Gaunt B, Gray CL et al. 2019. Rural and urban food allergy prevalence from the South African Food Allergy (SAFFA) study. J. Allergy Clin. Immunol. 143:2662–68.e2
    [Google Scholar]
13. Bousquet J, Reid J, van Weel C, Baena Cagnani C, Canonica GW et al. 2008. Allergic rhinitis management pocket reference 2008. Allergy 63:8990–96
    [Google Scholar]
14. Brough HA, Santos AF, Makinson K, Penagos M, Stephens AC et al. 2013. Peanut protein in household dust is related to household peanut consumption and is biologically active. J. Allergy Clin. Immunol. 132:3630–38
    [Google Scholar]
15. Brown SJ, McLean WHI. 2009. Eczema genetics: current state of knowledge and future goals. J. Investig. Dermatol. 129:3543–52
    [Google Scholar]
16. Brunwasser SM, Hartert TV. 2019. Practical and conceptual considerations for the primary prevention of asthma. Clin. Chest Med. 40:11–11
    [Google Scholar]
17. Camargo CA, Clark S, Kaplan MS, Lieberman P, Wood RA 2007. Regional differences in EpiPen prescriptions in the United States: the potential role of vitamin D. J. Allergy Clin. Immunol. 120:1131–36
    [Google Scholar]
18. COT (Comm. Toxic.). 2008. Statement on the review of the 1998 COT recommendations on peanut avoidance Comm. Toxic. Chem. Food Consum. Prod Environ., UK: https://cot.food.gov.uk/sites/default/files/cot/cotstatement200807peanut.pdf
    [Google Scholar]
19. Dreskin SC, Ayars A, Jin Y, Atkins D, Leo HL, Song B 2011. Association of genetic variants of CD14 with peanut allergy and elevated IgE levels in peanut allergic individuals. Ann. Allergy Asthma Immunol. 106:2170–72
    [Google Scholar]
20. Du Toit G, Katz Y, Sasieni P, Mesher D, Maleki SJ et al. 2008. Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy. J. Allergy Clin. Immunol 122:5984–91
    [Google Scholar]
21. Du Toit G, Roberts G, Sayre PH, Bahnson HT, Radulovic S et al. 2015. Randomized trial of peanut consumption in infants at risk for peanut allergy. N. Engl. J. Med. 372:9803–13
    [Google Scholar]
22. Du Toit G, Roberts G, Sayre PH, Plaut M, Bahnson HT et al. 2013. Identifying infants at high risk of peanut allergy: the Learning Early About Peanut Allergy (LEAP) screening study. J. Allergy Clin. Immunol. 131:1135–43.e1–12
    [Google Scholar]
23. Du Toit G, Sampson HA, Plaut M, Burks AW, Akdis CA, Lack G 2018. Food allergy: update on prevention and tolerance. J. Allergy Clin. Immunol. 141:130–40
    [Google Scholar]
24. Dubrac S, Schmuth M, Ebner S 2010. Atopic dermatitis: the role of Langerhans cells in disease pathogenesis. Immunol. Cell Biol. 88:4400–9
    [Google Scholar]
25. Emmett SE, Angus FJ, Fry JS, Lee PN 1999. Perceived prevalence of peanut allergy in Great Britain and its association with other atopic conditions and with peanut allergy in other household members. Allergy 54:4380–85
    [Google Scholar]
26. Fallon PG, Sasaki T, Sandilands A, Campbell LE, Saunders SP et al. 2009. A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming. Nat. Genet. 41:5602–8
    [Google Scholar]
27. Fisher HR, Du Toit G, Bahnson HT, Lack G 2018. The challenges of preventing food allergy: lessons learned from LEAP and EAT. Ann. Allergy Asthma Immunol. 121:3313–19
    [Google Scholar]
28. Flohr C, England K, Radulovic S, McLean WHI, Campbell LE et al. 2010. Filaggrin loss-of-function mutations are associated with early-onset eczema, eczema severity and transepidermal water loss at 3 months of age. Br. J. Dermatol 163:61333–36
    [Google Scholar]
29. Flohr C, Nagel G, Weinmayr G, Kleiner A, Strachan DP et al. 2011. Lack of evidence for a protective effect of prolonged breastfeeding on childhood eczema: lessons from the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Two. Br. J. Dermatol. 165:61280–89
    [Google Scholar]
30. Fox AT, Sasieni P, Du Toit G, Syed H, Lack G 2009. Household peanut consumption as a risk factor for the development of peanut allergy. J. Allergy Clin. Immunol. 123:2417–23
    [Google Scholar]
31. Frossard CP, Hauser C, Eigenmann PA 2004. Antigen-specific secretory IgA antibodies in the gut are decreased in a mouse model of food allergy. J. Allergy Clin. Immunol. 114:2377–82
    [Google Scholar]
32. Green R, Luyt D. 1997. Clinical characteristics of childhood asthmatics in Johannesburg. South Afr. Med. J. 87:7878–82
    [Google Scholar]
33. Greer FR, Sicherer SH, Burks AW 2008. Effects of early nutritional interventions on the development of atopic disease in infants and children: the role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods, and hydrolyzed formulas. Pediatrics 121:1183–91
    [Google Scholar]
34. Grimshaw K, Logan K, O'Donovan S, Kiely M, Patient K et al. 2017. Modifying the infant's diet to prevent food allergy. Arch. Dis. Child 102:2179–86
    [Google Scholar]
35. Gupta R, Blumenstock C, Kotowska J, Mittal J, Smith KB 2017. The prevalence of childhood food allergy in the United States: an update. Ann. Allergy Asthma Immunol. 119:5S11
    [Google Scholar]
36. Gupta R, Sheikh A, Strachan D, Anderson HR 2003. Increasing hospital admissions for systemic allergic disorders in England: analysis of national admissions data. BMJ 327:74241142–43
    [Google Scholar]
37. Gupta RS, Springston EE, Warrier MR, Smith B, Kumar R et al. 2011. The prevalence, severity, and distribution of childhood food allergy in the United States. Pediatrics 128:1e9–17
    [Google Scholar]
38. Gur M, Hakim F, Bentur L 2017. Better understanding of childhood asthma, towards primary prevention—are we there yet? Consideration of pertinent literature. F1000Res 6:2152
    [Google Scholar]
39. Halken S, Larenas-Linnemann D, Roberts G, Calderon MA, Angier E et al. 2017. EAACI guidelines on allergen immunotherapy: prevention of allergy. Pediatr. Allergy Immunol. 28:8728–45
    [Google Scholar]
40. Hill DJ, Hosking CS, Heine RG 1999. Clinical spectrum of food allergy in children in Australia and South-East Asia: identification and targets for treatment. Ann. Med. 31:4272–81
    [Google Scholar]
41. Hong XM, Wang GY, Liu X, Kumar R, Tsai HJ et al. 2011. Gene polymorphisms, breast-feeding, and development of food sensitization in early childhood. J. Allergy Clin. Immunol. 128:2374–91
    [Google Scholar]
42. Hourihane JO, Dean TP, Warner JO 1996. Peanut allergy in relation to heredity, maternal diet, and other atopic diseases: results of a questionnaire survey, skin prick testing, and food challenges. BMJ 313:7056518–21
    [Google Scholar]
43. Howard R, Belgrave D, Papastamoulis P, Simpson A, Rattray M, Custovic A 2018. Evolution of IgE responses to multiple allergen components throughout childhood. J. Allergy Clin. Immunol. 142:41322–30
    [Google Scholar]
44. Hwang BF, Jaakkola JJ, Lee YL, Lin YC, Guo YL 2006. Relation between air pollution and allergic rhinitis in Taiwanese schoolchildren. Respir. Res. 7:23
    [Google Scholar]
45. Hyppönen E, Sovio U, Wjst M, Patel S, Pekkanen J et al. 2004. Infant vitamin D supplementation and allergic conditions in adulthood: northern Finland birth cohort 1966. Ann. N. Y. Acad. Sci 1037:84–95
    [Google Scholar]
46. Ierodiakonou D, Garcia-Larsen V, Logan A, Groome A, Cunha S et al. 2016. Timing of allergenic food introduction to the infant diet and risk of allergic or autoimmune disease: a systematic review and meta-analysis. JAMA 316:111181–92
    [Google Scholar]
47. International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. 1998. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. Lancet 351:91111225–32
    [Google Scholar]
48. Jones SM, Sicherer SH, Burks AW, Leung DY, Lindblad RW et al. 2017. Epicutaneous immunotherapy for the treatment of peanut allergy in children and young adults. J. Allergy Clin. Immunol. 139:41242–52.e9
    [Google Scholar]
49. Katz Y, Rajuan N, Goldberg MR, Eisenberg E, Heyman E et al. 2010. Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy. J. Allergy Clin. Immunol. 126:177–82
    [Google Scholar]
50. Kerosuo H, Kullaa A, Kerosuo E, Kanerva L, Hensten-Pettersen A 1996. Nickel allergy in adolescents in relation to orthodontic treatment and piercing of ears. Am. J. Orthod. Dentofacial Orthop. 109:2148–54
    [Google Scholar]
51. Koplin JJ, Osborne NJ, Wake M, Martin PE, Gurrin LC et al. 2010. Can early introduction of egg prevent egg allergy in infants? A population-based study. J. Allergy Clin. Immunol. 126:4807–13
    [Google Scholar]
52. Kristiansen M, Dhami S, Netuveli G, Halken S, Muraro A et al. 2017. Allergen immunotherapy for the prevention of allergy: a systematic review and meta-analysis. Pediatr. Allergy Immunol. 28:118–29
    [Google Scholar]
53. Kukkonen K, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R et al. 2007. Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial. J. Allergy Clin. Immunol. 119:1192–98
    [Google Scholar]
54. Kumar R, Tsai HJ, Hong XM, Liu X, Wang GY et al. 2011. Race, ancestry, and development of food-allergen sensitization in early childhood. Pediatrics 128:4E821–29
    [Google Scholar]
55. Lack G. 2007. The concept of oral tolerance induction to foods. Nutr. Support Infants Children Risk 59:63–72
    [Google Scholar]
56. Lack G, Fox D, Northstone K, Golding J 2003. Factors associated with the development of peanut allergy in childhood. New Engl. J. Med. 348:11977–85
    [Google Scholar]
57. Lau S, Matricardi PM, Wahn U, Lee YA, Keil T 2019. Allergy and atopy from infancy to adulthood: messages from the German birth cohort MAS. Ann. Allergy Asthma Immunol. 122:125–32
    [Google Scholar]
58. Lee BW, Shek LP, Gerez IF, Soh SE, Van Bever HP 2008. Food allergy: lessons from Asia. World Allergy Organ. J. 1:7129–33
    [Google Scholar]
59. Liu X, Beaty TH, Deindl P, Huang SK, Lau S et al. 2004. Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study. J. Allergy Clin. Immunol. 113:3489–95
    [Google Scholar]
60. Lloyd-Lavery A, Solman L, Grindlay DJC, Rogers NK, Thomas KS, Harman KE 2019. What's new in atopic eczema? An analysis of systematic reviews published in 2016. II. Epidemiology, aetiology and risk factors. Clin. Exp. Dermatol. 44:370–75
    [Google Scholar]
61. Marth T, Strober W, Kelsall BL 1996. High dose oral tolerance in ovalbumin TCR-transgenic mice: Systemic neutralization of IL-12 augments TGF-β secretion and T cell apoptosis. J. Immunol. 157:62348–57
    [Google Scholar]
62. Martin PE, Eckert JK, Koplin JJ, Lowe AJ, Gurrin LC et al. 2015. Which infants with eczema are at risk of food allergy? Results from a population-based cohort. Clin. Exp. Allergy 45:1255–64
    [Google Scholar]
63. Milner JD, Stein DM, McCarter R, Moon RY 2004. Early infant multivitamin supplementation is associated with increased risk for food allergy and asthma. Pediatrics 114:127–32
    [Google Scholar]
64. Mortz CG, Lauritsen JM, Bindslev-Jensen C, Andersen KE 2002. Nickel sensitization in adolescents and association with ear piercing, use of dental braces and hand eczema. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis (TOACS). Acta Dermato Venereol 82:5359–64
    [Google Scholar]
65. Mullins RJ, Dear KB, Tang ML 2015. Time trends in Australian hospital anaphylaxis admissions in 1998–1999 to 2011–2012. J. Allergy Clin. Immunol. 136:2367–75
    [Google Scholar]
66. Natsume O, Kabashima S, Nakazato J, Yamamoto-Hanada K, Narita M et al. 2017. Two-step egg introduction for prevention of egg allergy in high-risk infants with eczema (PETIT): a randomised, double-blind, placebo-controlled trial. Lancet 389:10066276–86
    [Google Scholar]
67. PALISADE Group Clin. Investig. 2018. AR101 oral immunotherapy for peanut allergy. N. Engl. J. Med. 379:211991–2001
    [Google Scholar]
68. Palmer CNA, Irvine AD, Terron-Kwiatkowski A, Zhao YW, Liao HH et al. 2006. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat. Genet. 38:4441–46
    [Google Scholar]
69. Palmer DJ, Metcalfe J, Makrides M, Gold MS, Quinn P et al. 2013. Early regular egg exposure in infants with eczema: a randomized controlled trial. J. Allergy Clin. Immunol. 132:2387–92.e1
    [Google Scholar]
70. Palmer DJ, Sullivan TR, Gold MS, Prescott SL, Makrides M 2017. Randomized controlled trial of early regular egg intake to prevent egg allergy. J. Allergy Clin. Immunol. 139:51600–7.e2
    [Google Scholar]
71. Panjari M, Koplin JJ, Dharmage SC, Peters RL, Gurrin LC et al. 2016. Nut allergy prevalence and differences between Asian-born children and Australian-born children of Asian descent: a state-wide survey of children at primary school entry in Victoria, Australia. Clin. Exp. Allergy 46:4602–9
    [Google Scholar]
72. Pearce N, Aït-Khaled N, Beasley R, Mallol J, Keil U et al. 2007. Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 62:9758–66
    [Google Scholar]
73. Perkin MR, Logan K, Tseng A, Raji B, Ayis S et al. 2016. Randomized trial of introduction of allergenic foods in breast-fed infants. N. Engl. J. Med. 374:181733–43
    [Google Scholar]
74. Perry TT, Conover-Walker MK, Pomes A, Chapman MD, Wood RA 2004. Distribution of peanut allergen in the environment. J. Allergy Clin. Immunol. 113:5973–76
    [Google Scholar]
75. Peters RL, Koplin JJ, Dharmage SC, Tang MLK, McWilliam VL et al. 2019. Early exposure to cow's milk protein is associated with a reduced risk of cow's milk allergic outcomes. J. Allerg. Clin. Immunol. Pract. 7:462–70
    [Google Scholar]
76. Plunkett CH, Nagler CR. 2017. The influence of the microbiome on allergic sensitization to food. J. Immunol. 198:591–89
    [Google Scholar]
77. Pols DH, Wartna JB, van Alphen EI, Moed H, Rasenberg N et al. 2015. Interrelationships between atopic disorders in children: a meta-analysis based on ISAAC questionnaires. PLOS ONE 10:7e0131869
    [Google Scholar]
78. Poole JA, Barriga K, Leung DYM, Hoffman M, Eisenbarth GS et al. 2006. Timing of initial exposure to cereal grains and the risk of wheat allergy. J. Allergy Clin. Immunol. 117:2S42
    [Google Scholar]
79. Rona RJ, Keil T, Summers C, Gislason D, Zuidmeer L et al. 2007. The prevalence of food allergy: a meta-analysis. J. Allergy Clin. Immunol. 120:3638–46
    [Google Scholar]
80. Saulyte J, Regueira C, Montes-Martinez A, Khudyakov P, Takkouche B 2014. Active or passive exposure to tobacco smoking and allergic rhinitis, allergic dermatitis, and food allergy in adults and children: a systematic review and meta-analysis. PLOS Med. 11:3e1001611
    [Google Scholar]
81. Schindler T, Sinn JK, Osborn DA 2016. Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy. Cochrane Database Syst. Rev. 10:CD010112
    [Google Scholar]
82. Schmitt J, Schwarz K, Stadler E, Wustenberg EG 2015. Allergy immunotherapy for allergic rhinitis effectively prevents asthma: results from a large retrospective cohort study. J. Allergy Clin. Immunol. 136:61511–16
    [Google Scholar]
83. Scott M, Roberts G, Kurukulaaratchy RJ, Matthews S, Nove A, Arshad SH 2012. Multifaceted allergen avoidance during infancy reduces asthma during childhood with the effect persisting until age 18 years. Thorax 67:121046–51
    [Google Scholar]
84. Sears MR, Greene JM, Willan AR, Taylor DR, Flannery EM et al. 2002. Long-term relation between breastfeeding and development of atopy and asthma in children and young adults: a longitudinal study. Lancet 360:9337901–7
    [Google Scholar]
85. Shklovskaya E, O'Sullivan BJ, Ng LG, Roediger B, Thomas R et al. 2011. Langerhans cells are precommitted to immune tolerance induction. PNAS 108:18049–54
    [Google Scholar]
86. Sicherer SH. 2011. Epidemiology of food allergy. J. Allergy Clin. Immunol. 127:3594–602
    [Google Scholar]
87. Sicherer SH, Furlong TJ, Maes HH, Desnick RJ, Sampson HA, Gelb BD 2000. Genetics of peanut allergy: a twin study. J. Allergy Clin. Immunol. 106:153–56
    [Google Scholar]
88. Sicherer SH, Munoz-Furlong A, Sampson HA 2003. Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: a 5-year follow-up study. J. Allergy Clin. Immunol. 112:61203–7
    [Google Scholar]
89. Sicherer SH, Wood RA, Stablein D, Lindblad R, Burks AW et al. 2010. Maternal consumption of peanut during pregnancy is associated with peanut sensitization in atopic infants. J. Allergy Clin. Immunol. 126:61191–97
    [Google Scholar]
90. Smith FJD, Irvine AD, Terron-Kwiatkowski A, Sandilands A, Campbell LE et al. 2006. Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris. Nat. Genet. 38:3337–42
    [Google Scholar]
91. Strid J, Thomson M, Hourihane J, Kimber I, Strobel S 2004. A novel model of sensitization and oral tolerance to peanut protein. Immunology 113:3293–303
    [Google Scholar]
92. Tan JW-L, Valerio C, Barnes EH, Turner PJ, Van Asperen PA et al. 2017. A randomized trial of egg introduction from 4 months of age in infants at risk for egg allergy. J. Allergy Clin. Immunol. 139:51621–28.e8
    [Google Scholar]
93. Taylor-Robinson DC, Williams H, Pearce A, Law C, Hope S 2016. Do early-life exposures explain why more advantaged children get eczema? Findings from the U.K. Millennium Cohort Study. Br. J. Dermatol. 174:3569–78
    [Google Scholar]
94. Thomas KS, Dean T, O'Leary C, Sach TH, Koller K, Frost A et al. 2011. A randomised controlled trial of ion-exchange water softeners for the treatment of eczema in children. PLOS MED 8:2e1000395
    [Google Scholar]
95. Togias A, Cooper SF, Acebal ML, Assa'ad A, Baker JR Jr et al. 2017. Addendum guidelines for the prevention of peanut allergy in the United States: report of the National Institute of Allergy and Infectious Diseases–sponsored expert panel. J. Allergy Clin. Immunol. 139:129–44
    [Google Scholar]
96. Tordesillas L, Berin MC. 2018. Mechanisms of oral tolerance. Clin. Rev. Allergy Immunol. 55:107–17
    [Google Scholar]
97. Tordesillas L, Mondoulet L, Blazquez AB, Benhamou PH, Sampson HA et al. 2017. Epicutaneous immunotherapy induces gastrointestinal LAP⁺ regulatory T cells and prevents food-induced anaphylaxis. J. Allergy Clin. Immunol. 139:189–201
    [Google Scholar]
98. Turcanu V, Brough HA, Du Toit G, Foong RX, Marrs T et al. 2017. Immune mechanisms of food allergy and its prevention by early intervention. Curr. Opin. Immunol. 48:92–98
    [Google Scholar]
99. Vassallo MF, Banerji A, Rudders SA, Clark S, Mullins RJ, Camargo CA 2010. Season of birth is associated with risk of food allergy in children. J. Allergy Clin. Immunol. 125:2AB217
    [Google Scholar]
100. Venter C, Brown KR, Maslin K, Palmer DJ 2017. Maternal dietary intake in pregnancy and lactation and allergic disease outcomes in offspring. Pediatr. Allergy Immunol. 28:2135–43
     [Google Scholar]
101. Wang Y, Allen KJ, Suaini NHA, McWilliam V, Peters RL, Koplin JJ 2019. The global incidence and prevalence of anaphylaxis in children in the general population: a systematic review. Allergy 74:61063–80
     [Google Scholar]
102. Weidinger S, Beck LA, Bieber T, Kabashima K, Irvine AD 2018. Atopic dermatitis. Nat. Rev. Dis. Primers 4:1
     [Google Scholar]
103. Wjst M. 2005. Another explanation for the low allergy rate in the rural Alpine foothills. Clin. Mol. Allergy 3:7
     [Google Scholar]
104. Wolsk HM, Chawes BL, Litonjua AA, Hollis BW, Waage J et al. 2017. Prenatal vitamin D supplementation reduces risk of asthma/recurrent wheeze in early childhood: a combined analysis of two randomized controlled trials. PLOS ONE 12:10e0186657
     [Google Scholar]
105. Woodcock A, Lowe LA, Murray CS, Simpson BM, Pipis SD et al. 2004. Early life environmental control: effect on symptoms, sensitization, and lung function at age 3 years. Am. J. Respir. Crit. Care Med. 170:4433–39
     [Google Scholar]
106. Yokota-Nakatsuma A, Takeuchi H, Ohoka Y, Kato C, Song SY et al. 2014. Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells. Mucosal Immunol 7:786–801
     [Google Scholar]
107. Yoshihara S, Ono M, Yamada Y, Fukuda H, Abe T, Arisaka O 2009. Early intervention with suplatast tosilate for prophylaxis of pediatric atopic asthma: a pilot study. Pediatr. Allergy Immunol. 20:5486–92
     [Google Scholar]
108. Zeiger RS, Heller S. 1995. The development and prediction of atopy in high-risk children: follow-up at age seven years in a prospective randomized study of combined maternal and infant food allergen avoidance. J. Allergy Clin. Immunol. 95:61179–90
     [Google Scholar]
109. Zheng T, Yu J, Oh MH, Zhu Z 2011. The atopic march: progression from atopic dermatitis to allergic rhinitis and asthma. Allergy Asthma Immunol. Res. 3:267–73
     [Google Scholar]
110. Zolkipli Z, Roberts G, Cornelius V, Clayton B, Pearson S et al. 2015. Randomized controlled trial of primary prevention of atopy using house dust mite allergen oral immunotherapy in early childhood. J. Allergy Clin. Immunol. 136:61541–47.e11
     [Google Scholar]