1932

Abstract

Gastric mixing is a complex process that is governed by meal properties, such as food buffering capacity, physical properties, and the rate of breakdown as well as physiological factors, such as the rate of gastric secretions, gastric emptying, and gastric motility. Gastric mixing processes have been studied through the use of experimental and computational methods. Gastric mixing impacts the intragastric pH distribution and residence time in the stomach for ingested materials. Development of a fundamental understanding of the advective and diffusion processes and their roles in gastric mixing will be important in furthering our understanding of food breakdown, microbial survival, and drug dissolution during gastric digestion.

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2017-02-28
2024-06-17
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Literature Cited

  1. Alam A, Afzal A, Kim K-Y. 2014. Mixing performance of a planar micromixer with circular obstructions in a curved microchannel. Chem. Eng. Res. Des. 92:423–34 [Google Scholar]
  2. Ali S, Menanteau S, Habchi C, Lemenand T, Harion J-L. 2016. Heat transfer and mixing enhancement by using multiple freely oscillating flexible vortex generators. Appl. Therm. Eng. 105:276–89 [Google Scholar]
  3. Ange KD, Eisemann JH, Argenzio RA, Almond GW, Blikslager AT. 2000. Effects of feed physical form and buffering solutes on water disappearance and proximal stomach pH in swine. J. Anim. Sci. 78:2344–52 [Google Scholar]
  4. Asmar NB, Langston AP, Matchett JA. 2002. A generalised mixing index in distinct element method simulation of vibrated particulate beds. Granul. Matter 4:129–38 [Google Scholar]
  5. Barrett KE. 2014. Gastrointestinal Physiology New York: McGraw-Hill [Google Scholar]
  6. Barton C, Raynor S. 1968. Peristaltic flow in tubes. Bull. Math. Biol. 30:663–80 [Google Scholar]
  7. Beaumont H, Bennink RJ, Jong J, Boeckxstaens GE. 2010. The position of the acid pocket as a major risk factor for acidic reflux in healthy subjects and patients with GORD. Gut 59:441–51 [Google Scholar]
  8. Bezkorovainy A. 2001. Probiotics: determinants of survival and growth in the gut. Am. J. Clin. Nutr. 73:399s–405s [Google Scholar]
  9. Bohme G, Friedrich R. 1983. Peristaltic flow of viscoelastic liquids. J. Fluid Mech. 128:109–22 [Google Scholar]
  10. Boland M. 2016. Human digestion—a processing perspective. J. Sci. Food Agric. 96:2275–83 [Google Scholar]
  11. Bornhorst GM, Drechsler KC, Montoya CA, Rutherfurd SM, Moughan PJ, Singh RP. 2016a. Gastric protein hydrolysis of raw and roasted almonds in the growing pig. Food Chem 211:502–8 [Google Scholar]
  12. Bornhorst GM, Gouseti O, Wickham MSJ, Bakalis S. 2016b. Engineering digestion: multiscale processes of food digestion. J. Food Sci. 81:R534–43 [Google Scholar]
  13. Bornhorst GM, Hivert H, Singh RP. 2014a. Rice bolus texture changes due to α-amylase. LWT Food Sci. Technol. 55:27–33 [Google Scholar]
  14. Bornhorst GM, Rutherfurd SM, Roman MJ, Burri BJ, Moughan PJ, Singh RP. 2014b. Gastric pH distribution and mixing of soft and rigid food particles in the stomach using a dual-marker technique. Food Biophys 9:292–300Quantifies solid-solid mixing index and intragastric pH in soft and rigid meals in pigs. [Google Scholar]
  15. Bornhorst GM, Singh RP. 2014. Gastric digestion in vivo and in vitro: how the structural aspects of food influence the digestion process. Annu. Rev. Food Sci. Technol. 5:111–32 [Google Scholar]
  16. Charman WN, Porter CJH, Mithani S, Dressman JB. 1997. Physicochemical and physiological mechanisms for the effects of food on drug absorption: the role of lipids and pH. J. Pharm. Sci. 86:269–82 [Google Scholar]
  17. Cheng Y, Zhang W, Guan G, Fushimi C, Tsutsumi A, Wang C-H. 2014. Numerical studies of solid–solid mixing behaviors in a downer reactor for coal pyrolysis. Powder Technol 253:722–32 [Google Scholar]
  18. Clavel T, Carlin F, Lairon D, Nguyen-The C, Schmitt P. 2004. Survival of Bacillus cereus spores and vegetative cells in acid media simulating human stomach. J. Appl. Microbiol. 97:214–19 [Google Scholar]
  19. Cullen P. 2009. Food Mixing Principles and Applications Oxford, UK: Blackwell Publishing [Google Scholar]
  20. d'Aoust J. 1985. Infective dose of Salmonella typhimurium in cheddar cheese. Am. J. Epidemiol. 122:717–20 [Google Scholar]
  21. Danckwerts P. 1952. The definition and measurement of some characteristics of mixtures. Appl. Sci. Res. 3:279–96 [Google Scholar]
  22. de Jonge R, Takumi K, Ritmeester WS, van Leusden FM. 2003. The adaptive response of Escherichia coli O157 in an environment with changing pH. J. Appl. Microbiol. 94:555–60 [Google Scholar]
  23. Debas HT, Cohen MM, Holubitsky IB, Harrison RC. 1971. Caffeine-stimulated acid and pepsin secretion: dose-response studies. Scand. J. Gastroenterol. 6:453–57 [Google Scholar]
  24. Dekkers B, Kolodziejczyk E, Acquistapace S, Engmann J, Wooster T. 2016. Impact of gastric pH profiles on the proteolytic digestion of mixed βlg-Xanthan biopolymer gels. Food Funct 7:58–68Shows a faster rate of protein digestion at low static pH compared to higher dynamic pH profile. [Google Scholar]
  25. Epelboym I, Mazeh H. 2014. Zollinger-Ellison syndrome: classical considerations and current controversies. Oncologist 19:44–50 [Google Scholar]
  26. Fan LT, Chen Y-M, Lai FS. 1990. Recent developments in solids mixing. Powder Technol 61:255–87 [Google Scholar]
  27. Fan LT, Too JR, Rubison RM, Lai FS. 1979. Studies on multicomponent solids mixing and mixtures: Part III. Mixing indices. Powder Technol 24:73–89 [Google Scholar]
  28. Fauci LJ. 1992. Peristaltic pumping of solid particles. Comput. Fluids 21:583–98 [Google Scholar]
  29. Feldman M, Cryer B, McArthur KE, Huet BA, Lee E. 1996. Effects of aging and gastritis on gastric acid and pepsin secretion in humans: a prospective study. Gastroenterology 110:1043–52 [Google Scholar]
  30. Ferrua MJ, Singh RP. 2010. Modeling the fluid dynamics in a human stomach to gain insight of food digestion. J. Food Sci. 75:R151–62 [Google Scholar]
  31. Ferrua MJ, Xue Z, Singh RP. 2014. On the kinematics and efficiency of advective mixing during gastric digestion—a numerical analysis. J. Biomech. 47:3664–73Quantifies gastric fluid flow, shear rate, and mixing using a 3D computational fluid dynamic model. [Google Scholar]
  32. Fletcher J, Wirz A, Young J, Vallance R, McColl KEL. 2001. Unbuffered highly acidic gastric juice exists at the gastroesophageal junction after a meal. Gastroenterology 121:775–83 [Google Scholar]
  33. Forster J, Sarosiek I, Delcore R, Lin Z, Raju GS, McCallum RW. 2001. Gastric pacing is a new surgical treatment for gastroparesis. Am. J. Surg. 182:676–81 [Google Scholar]
  34. Gao Y, van Reenen A, Hulsen MA, de Jong AM, Prins MWJ, den Toonder JMJ. 2014. Chaotic fluid mixing by alternating microparticle topologies to enhance biochemical reactions. Microfluid. Nanofluid. 16:265–74 [Google Scholar]
  35. Gardiner G, Stanton C, Lynch PB, Collins JK, Fitzgerald G, Ross RP. 1999. Evaluation of cheddar cheese as a food carrier for delivery of a probiotic strain to the gastrointestinal tract. J. Dairy Sci. 82:1379–87 [Google Scholar]
  36. Gargouri Y, Moreau H, Verger R. 1989. Gastric lipases: biochemical and physiological studies. Biochim. Biophys. Acta 1006:255–71 [Google Scholar]
  37. Ge W, Han Y, Wang J, Wang L, Liu X. et al. 2015. Comparative study on the characterization method of particle mixing index using DEM method. Procedia Eng 102:1630–42 [Google Scholar]
  38. Gerez CL, Font de Valdez G, Gigante ML, Grosso CRF. 2012. Whey protein coating bead improves the survival of the probiotic Lactobacillus rhamnosus CRL 1505 to low pH. Lett. Appl. Microbiol. 54:552–56 [Google Scholar]
  39. Gopirajah R, Anandharamakrishnan C. 2016. Advancement of imaging and modeling techniques for understanding gastric physical forces on food. Food Eng. Rev. 8:323–35 [Google Scholar]
  40. Halidan M, Chandratilleke GR, Dong K, Yu A. 2016. The effect of interparticle cohesion on powder mixing in a ribbon mixer. AIChE J 62:1023–37 [Google Scholar]
  41. Hammond CE, Beeson C, Suarez G, Peek RM, Backert S, Smolka AJ. 2015. Helicobacter pylori virulence factors affecting gastric proton pump expression and acid secretion. Am. J. Physiol. Gastrointest. Liver Physiol. 309:G193–201 [Google Scholar]
  42. Hamosh M. 1990. Lingual and gastric lipases. Nutrition 6:421–28 [Google Scholar]
  43. Hardoff R, Sula M, Tamir A, Soil A, Front A. et al. 2001. Gastric emptying time and gastric motility in patients with Parkinson's disease. Mov. Disord. 16:1041–47 [Google Scholar]
  44. Hari B, Bakalis S, Fryer PJ. 2012. Computational modelling and simulation of the human duodenum Presented at COMSOL Conf., Milan, Italy [Google Scholar]
  45. Hayat T, Ali N. 2006. On mechanism of peristaltic flows for power-law fluids. Phys. A. 371:188–94 [Google Scholar]
  46. Hermansson G, Sivertsson R. 1996. Gender-related differences in gastric emptying rate of solid meals. Dig. Dis. Sci. 41:1994–98 [Google Scholar]
  47. Holdsworth JD, Johnson K, Mascall G, Roulston RG, Tomlinson PA. 1980. Mixing of antacids with stomach contents. Anaesthesia 35:641–50 [Google Scholar]
  48. Hutchings JB, Lilliford PJ. 1988. The perception of food texture—the philosophy of the breakdown path. J. Texture Stud. 19:103–15 [Google Scholar]
  49. Karimi H, Molaei Dehkordi A. 2015. Prediction of equilibrium mixing state in binary particle spouted beds: effects of solids density and diameter differences, gas velocity, and bed aspect ratio. Adv. Powder Technol. 26:1371–82 [Google Scholar]
  50. Kelly KA. 1980. Gastric emptying of liquids and solids: roles of proximal and distal stomach. Am. J. Physiol. Gastrointest. Liver Physiol. 239:G71–76 [Google Scholar]
  51. Kondjoyan A, Daudin J-D, Santé-Lhoutellier V. 2015. Modelling of pepsin digestibility of myofibrillar proteins and of variations due to heating. Food Chem 172:265–71 [Google Scholar]
  52. Kong F, Singh R. 2009. Modes of disintegration of solid foods in simulated gastric environment. Food Biophys 4:180–90 [Google Scholar]
  53. Koseki S, Mizuno Y, Sotome I. 2011. Modeling of pathogen survival during simulated gastric digestion. Appl. Environ. Microbiol. 77:1021–32 [Google Scholar]
  54. Kumar S, Kim HJ, Beskok A. 2007. Numerical simulations of peristaltic mixing. J. Fluids Eng. 129:1361–71 [Google Scholar]
  55. Kwiatek MA, Menne D, Steingoetter A, Goetze O, Forras-Kaufman Z. et al. 2009. Effect of meal volume and calorie load on postprandial gastric function and emptying: studies under physiological conditions by combined fiber-optic pressure measurement and MRI. Am. J. Physiol. Gastrointest. Liver Physiol. 297:G894–901 [Google Scholar]
  56. Kwiatek MA, Roman S, Fareeduddin A, Pandolfino JE, Kahrilas PJ. 2011. An alginate-antacid formulation (Gaviscon Double Action Liquid) can eliminate or displace the postprandial ‘acid pocket’ in symptomatic GERD patients. Aliment. Pharmacol. Ther. 34:59–66 [Google Scholar]
  57. Lacey PMC. 1943. The mixing of solid particles. Trans. Inst. Chem. Eng. 21:53 [Google Scholar]
  58. Lacey PMC. 1954. Developments in the theory of particle mixing. J. Appl. Chem. 4:257–68 [Google Scholar]
  59. Lahner E, Annibale B, Delle Fave G. 2009. Systematic review: impaired drug absorption related to the co-administration of antisecretory therapy. Aliment. Pharmacol. Ther. 29:1219–29 [Google Scholar]
  60. Lambert RA, Rangel RH. 2010. The role of elastic flap deformation on fluid mixing in a microchannel. Phys. Fluids 22:052003 [Google Scholar]
  61. Lamers CBHW, Lind T, Moberg S, Jansen JBMJ, Olbe L. 1984. Omeprazole in Zollinger–Ellison syndrome—effects of a single dose and of long-term treatment in patients resistant to histamine H2-receptor antagonists. N. Engl. J. Med. 310:758–61 [Google Scholar]
  62. Lammers WJEP, Ver Donck L, Stephen B, Smets D, Schuurkes JAJ. 2009. Origin and propagation of the slow wave in the canine stomach: the outlines of a gastric conduction system. Am. J. Physiol. Gastrointest. Liver Physiol. 296:G1200–10 [Google Scholar]
  63. Lanas A, Htrschowitz BT. 1992. Influence of smoking on basal and on vagally and maximally stimulated gastric acid and pepsin secretion. Scand. J. Gastroenterol. 27:208–12 [Google Scholar]
  64. Lind T, Cederberg C, Ekenved G, Haglund U, Olbe L. 1983. Effect of omeprazole—a gastric proton pump inhibitor—on pentagastrin stimulated acid secretion in man. Gut 24:270–76 [Google Scholar]
  65. Liu PY, Yang RY, Yu AB. 2013. DEM study of the transverse mixing of wet particles in rotating drums. Chem. Eng. Sci. 86:99–107 [Google Scholar]
  66. Love RJ, Lentle RG, Asvarujanon P, Hemar Y, Stafford KJ. 2013. An expanded finite element model of the intestinal mixing of digesta. Food Dig 4:26–35 [Google Scholar]
  67. Malagelada J-R, Go VLW, Summerskill WHJ. 1979. Different gastric, pancreatic, and biliary responses to solid-liquid or homogenized meals. Dig. Dis. Sci. 24:101–10 [Google Scholar]
  68. Mandalari G, Adel-Patient K, Barkholt V, Baro C, Bennett L. et al. 2009. In vitro digestibility of β-casein and β-lactoglobulin under simulated human gastric and duodenal conditions: a multi-laboratory evaluation. Regul. Toxicol. Pharmacol. 55:372–81 [Google Scholar]
  69. Marciani L, Gowland PA, Fillery-Travis A, Manoj P, Wright J. et al. 2001a. Assessment of antral grinding of a model solid meal with echo-planar imaging. Am. J. Physiol. Gastrointest. Liver Physiol. 280:G844–49 [Google Scholar]
  70. Marciani L, Gowland PA, Spiller RC, Manoj P, Moore RJ. et al. 2001b. Effect of meal viscosity and nutrients on satiety, intragastric dilution, and emptying assessed by MRI. Am. J. Physiol. Gastrointest. Liver Physiol. 280:G1227–33Uses magnetic resonance imaging to assess intragastric dilution of high and low viscosity meals. [Google Scholar]
  71. Marciani L, Hall N, Pritchard SE, Cox EF, Totman JJ. et al. 2012. Preventing gastric sieving by blending a solid/water meal enhances satiation in healthy humans. J. Nutr. 142:1253–58 [Google Scholar]
  72. Marciani L, Wickham MSJ, Bush D, Faulks R, Wright J. et al. 2006. Magnetic resonance imaging of the behaviour of oil-in-water emulsions in the gastric lumen of man. Br. J. Nutr. 95:331–39 [Google Scholar]
  73. Marciani L, Young P, Wright J, Moore R, Coleman N. et al. 2001c. Antral motility measurements by magnetic resonance imaging. Neurogastroenterol. Motil. 13:511–18 [Google Scholar]
  74. Marra F, Ferrua MJ, Singh RP. 2011. Experimental characterization of the fluid dynamics in an in vitro system simulating the peristaltic movement of the stomach wall Presented at 11th Int. Congr. Eng. Food (ICEF11), Athens, Greece [Google Scholar]
  75. Mattioli S, Felice V, Pilotti V, Bacchi ML, Pàstina M, Gozzetti G. 1992. Indications for 24-hour gastric pH monitoring with single and multiple probes in clinical research and practice. Dig. Dis. Sci. 37:1793–801 [Google Scholar]
  76. Mattioli S, Pilotti V, Felice V, Lazzari A, Zannoli R. et al. 1990. Ambulatory 24-hr pH monitoring of esophagus, fundus, and antrum. Dig. Dis. Sci. 35:929–38 [Google Scholar]
  77. Maxwell CV, Reimann EM, Hoekstra WG, Kowalczyk T, Benevenga NJ, Grummer RH. 1972. Use of tritiated water to assess, in vivo, the effect of dietary particle size on the mixing of stomach contents of swine. J. Anim. Sci. 34:212–16 [Google Scholar]
  78. McCallum RW, De Z, Chen J, Lin Z, Schirmer BD. et al. 1998. Gastric pacing improves emptying and symptoms in patients with gastroparesis. Gastroenterology 114:456–61 [Google Scholar]
  79. Mennah-Govela YA, Bornhorst GM. 2016. Acid and moisture uptake in steamed and boiled sweet potatoes and associated structural changes during in vitro gastric digestion. Food Res. Int. 88:247–55 [Google Scholar]
  80. Mennah-Govela YA, Bornhorst GM, Singh RP. 2015. Acid diffusion into rice boluses is influenced by rice type, variety, and presence of α-amylase. J. Food Sci. 80:E316–25Models gastric acid diffusion into boluses of brown and white rice of different varieties. [Google Scholar]
  81. Meyer JH. 1980. Gastric emptying of ordinary food: effect of antrum on particle size. Am. J. Physiol. Gastrointest. Liver Physiol. 239:G133–35 [Google Scholar]
  82. Miles SR. 1962. Heterogeneity of seed lots. Proc. Int. Seed Test. Assoc. 27:407–13 [Google Scholar]
  83. Mitra A, Kesisoglou F. 2013. Impaired drug absorption due to high stomach pH: a review of strategies for mitigation of such effect to enable pharmaceutical product development. Mol. Pharm. 10:3970–79 [Google Scholar]
  84. Moore JG, Datz FL, Christian PE. 1990. Exercise increases solid meal gastric emptying rates in men. Dig. Dis. Sci. 35:428–32 [Google Scholar]
  85. Mößeler A, Köttendorf S, Große Liesner V, Kamphues J. 2010. Impact of diets’ physical form (particle size; meal/pelleted) on the stomach content (dry matter content, pH, chloride concentration) of pigs. Livestock Sci 134:146–48 [Google Scholar]
  86. Mößeler AK, Wintermann MF, Beyerbach M, Kamphues J. 2014. Effects of grinding intensity and pelleting of the diet—fed either dry or liquid—on intragastric milieu, gastric lesions and performance of swine. Anim. Feed Sci. Technol. 194:113–20 [Google Scholar]
  87. Mourot J, Thouvenot P, Couet C, Antoine J, Krobicka A, Debry G. 1988. Relationship between the rate of gastric emptying and glucose and insulin responses to starchy foods in young healthy adults. Am. J. Clin. Nutr. 48:1035–40 [Google Scholar]
  88. Nahar S. 2012. Steady and unsteady flow characteristics of non-Newtonian fluids in deformed elastic tubes PhD Thesis, ETH Zurich [Google Scholar]
  89. O'Grady G, Du P, Cheng LK, Egbuji JU, Lammers WJEP. et al. 2010. Origin and propagation of human gastric slow-wave activity defined by high-resolution mapping. Am. J. Physiol. Gastrointest. Liver Physiol. 299:G585–92 [Google Scholar]
  90. Oktedalen O, Guldvog I, Opstad PK, Berstad A, Gedde-Dahl D, Jorde R. 1984. The effect of physical stress on gastric secretion and pancreatic polypeptide levels in man. Scand. J. Gastroenterol. 19:770–78 [Google Scholar]
  91. Olausson EA, Brock C, Drewes AM, Grundin H, Isaksson M. et al. 2013. Measurement of gastric emptying by radiopaque markers in patients with diabetes: correlation with scintigraphy and upper gastrointestinal symptoms. Neurogastroenterol. Motil. 25:e224–32 [Google Scholar]
  92. Olbe L. 2012. Proton Pump Inhibitors Basel, Switz: Birkhäuser [Google Scholar]
  93. Pal A, Indireshkumar K, Schwizer W, Abrahamsson B, Fried M, Brasseur JG. 2004. Gastric flow and mixing studied using computer simulation. Proc. R. Soc. Lond. Ser. B 271:2587–94 [Google Scholar]
  94. Pandolfino JE, Zhang Q, Ghosh SK, Post J, Kwiatek M, Kahrilas PJ. 2007. Acidity surrounding the squamocolumnar junction in GERD patients: “acid pocket” versus “acid film”. Am. J. Gastroenterol. 102:2633–41 [Google Scholar]
  95. Persson EM, Gustafsson A-S, Carlsson AS, Nilsson RG, Knutson L. et al. 2005. The effects of food on the dissolution of poorly soluble drugs in human and in model small intestinal fluids. Pharm. Res. 22:2141–51 [Google Scholar]
  96. Phillips LK, Deane AM, Jones KL, Rayner CK, Horowitz M. 2015. Gastric emptying and glycaemia in health and diabetes mellitus. Nat. Rev. Endocrinol. 11:112–28 [Google Scholar]
  97. Piper D, Fenton BH. 1965. pH stability and activity curves of pepsin with special reference to their clinical importance. Gut 6:506–8 [Google Scholar]
  98. Pitino I, Randazzo CL, Cross KL, Parker ML, Bisignano C. et al. 2012. Survival of Lactobacillus rhamnosus strains inoculated in cheese matrix during simulated human digestion. Food Microbiol 31:57–63 [Google Scholar]
  99. Pletschke BI, Naudé RJ, Oelofsen W. 1995. Ostrich pepsins I and II: a kinetic and thermodynamic investigation. Int. J. Biochem. Cell Biol. 27:1293–302 [Google Scholar]
  100. Rauscher E, Neumann U, Schaich E, von Bülow S, Wahlefeld AW. 1985. Optimized conditions for determining activity concentration of alpha-amylase in serum, with 1,4-alpha-D-4-nitrophenylmaltoheptaoside as substrate. Clin. Chem. 31:14–19 [Google Scholar]
  101. Regina DC, Eisemann JH, Lang JA, Argenzio RA. 1999. Changes in gastric contents in pigs fed a finely ground and pelleted or coarsely ground meal diet. J. Anim. Sci. 77:2721–29 [Google Scholar]
  102. Ren B, Zhong W, Jin B, Shao Y, Yuan Z. 2013. Numerical simulation on the mixing behavior of corn-shaped particles in a spouted bed. Powder Technol 234:58–66 [Google Scholar]
  103. Rielly CD, Smith DLO, Lindley JA, Niranjan K, Phillips VR. 1994. Mixing processes for agricultural and food materials: Part 4, assessment and monitoring of mixing systems. J. Agric. Eng. Res. 59:1–18Describes mixing processes and mixing index calculation for solid mixing in food processing. [Google Scholar]
  104. Riff BP, Leiman DA, Bennett B, Fraker DL, Metz DC. 2016. Weight gain in Zollinger-Ellison syndrome after acid suppression. Pancreas 45:193–97 [Google Scholar]
  105. Robbins R, Idjadi F, Stahl WM, Essiet G. 1972. Studies of gastric secretion in stressed patients. Ann. Surg. 175:555–62 [Google Scholar]
  106. Rose HE, Robinson DJ. 1965. The application of the digital computer to the study of some problems in the mixing of powders. Am. Inst. Chem. Eng. Symp. Ser. 10: [Google Scholar]
  107. Rosenblum JL, Irwin CL, Alpers DH. 1988. Starch and glucose oligosaccharides protect salivary-type amylase activity at acid pH. Am. J. Physiol. Gastrointest. Liver Physiol. 254:G775–80 [Google Scholar]
  108. Rubach M, Lang R, Bytof G, Stiebitz H, Lantz I. et al. 2014. A dark brown roast coffee blend is less effective at stimulating gastric acid secretion in healthy volunteers compared to a medium roast market blend. Mol. Nutr. Food Res. 58:1370–73 [Google Scholar]
  109. Saxena A, Shah D, Padmanabhan S, Gautam SS, Chowan GS. et al. 2015. Prediction of pH dependent absorption using in vitro, in silico, and in vivo rat models: early liability assessment during lead optimization. Eur. J. Pharm. Sci. 76:173–80 [Google Scholar]
  110. Schofield C. 1976. The definition and assessment of mixture quality in mixtures of particulate solids. Powder Technol 15:169–80 [Google Scholar]
  111. Schubert ML, Peura DA. 2008. Control of gastric acid secretion in health and disease. Gastroenterology 134:1842–60Describes mechanisms of gastric acid secretion in healthy and diseased adults. [Google Scholar]
  112. Shapiro AH, Jaffrin MY, Weinberg SL. 1969. Peristaltic pumping with long wavelengths at low Reynolds number. J. Fluid Mech. 37:799–825 [Google Scholar]
  113. Shi L-E, Li Z-H, Li D-T, Xu M, Chen H-Y. et al. 2013. Encapsulation of probiotic Lactobacillus bulgaricus in alginate–milk microspheres and evaluation of the survival in simulated gastrointestinal conditions. J. Food Eng. 117:99–104 [Google Scholar]
  114. Siddiqui AM, Schwarz WH. 1994. Peristaltic flow of a second-order fluid in tubes. J. Non-Newton. Fluid Mech. 53:257–84 [Google Scholar]
  115. Singh H, Ye A, Ferrua MJ. 2015. Aspects of food structures in the digestive tract. Curr. Opin. Food Sci. 3:85–93 [Google Scholar]
  116. Smith JL. 2003. The role of gastric acid in preventing foodborne disease and how bacteria overcome acid conditions. J. Food Prot. 66:1292–303 [Google Scholar]
  117. Srivastava V. 2007. A theoretical model for blood flow in small vessels. Appl. Appl. Math. 2:51–65 [Google Scholar]
  118. Steingoetter A, Sauter M, Curcic J, Liu D, Menne D. et al. 2015. Volume, distribution and acidity of gastric secretion on and off proton pump inhibitor treatment: a randomized double-blind controlled study in patients with gastro-esophageal reflux disease (GERD) and healthy subjects. BMC Gastroenterol 15:111Quantifies volume and distribution of gastric secretions in the proximal stomach after liquid meals using MRI. [Google Scholar]
  119. Takumi K, De Jonge R, Havelaar A. 2000. Modelling inactivation of Escherichia coli by low pH: application to passage through the stomach of young and elderly people. J. Appl. Microbiol. 89:935–43 [Google Scholar]
  120. Tamplin ML. 2005. Inactivation of Escherichia coli O157:H7 in simulated human gastric fluid. Appl. Environ. Microbiol. 71:320–25 [Google Scholar]
  121. Tharakan A. 2008. Modelling of Physical and Chemical Processes in the Small Intestine Birmingham, AL: Univ. Birm. [Google Scholar]
  122. Ulleberg E, Comi I, Holm H, Herud E, Jacobsen M, Vegarud G. 2011. Human gastrointestinal juices intended for use in in vitro digestion models. Food Dig 2:52–61 [Google Scholar]
  123. Waterman SR, Small PLC. 1998. Acid-sensitive enteric pathogens are protected from killing under extremely acidic conditions of pH 2.5 when they are inoculated onto certain solid food sources. Appl. Environ. Microbiol. 64:3882–86 [Google Scholar]
  124. Weitschies W, Wedemeyer R-S, Kosch O, Fach K, Nagel S. et al. 2005. Impact of the intragastric location of extended release tablets on food interactions. J. Control. Release 108:375–85Shows that tablets had long residence times in the proximal stomach when consumed after a meal. [Google Scholar]
  125. Zhou T, Li B, Peng C, Ji B-P, Chen G, Ren Y-L. 2009. Assessment of the sequential simulated gastrointestinal tolerance of lactic acid bacteria from kefir grains by response surface methodology. J. Food Sci. 74:M328–34 [Google Scholar]
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