Engineering the Gramicidin Channel

Supplementary Data

• Figure 2. Space-filling model representation of the single-stranded {BETA}^6.3-helical gramicidin channel structure. (Modified from Koeppe et al, 1992, Proteins 12:49-62.)

  

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  Figure 7. Schematic two-state model for the gating sensor in [F₆Val¹]gA/[Val¹]gA channels. A space-filling model similar to that in Figure 2 is shown for a gramicidin channel, with a single hexafluorovaline side-chain dipole in two possible orientations with respect to an external transmembrane potential.