1932

Abstract

Oil-water partitioning, solubilities, and vapor pressure experiments on small-molecule compounds are often used as models to obtain energies for biomolecular modeling. For example, measured partition coefficients, , are often inserted into the formula −ln to obtain quantities thought to represent microscopic contact interaction free energies. We review evidence here that this procedure does not always give microscopically meaningful free energies. Some partitioning processes, particularly involving polymeric solvents such as octanol or hexadecane, are governed not only by translational entropies and contact interactions, but also by free energies resulting from changes in the conformations of the polymer chains upon solute insertion. The Flory-Huggins theory is more suitable for these situations than is the classical approach. We discuss the physical bases for both approaches.

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/content/journals/10.1146/annurev.biophys.26.1.425
1997-06-01
2024-06-21
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  • Article Type: Review Article
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