1932

Abstract

Phosphatidylinositol 4,5-bisphosphate (PIP) is a minority phospholipid of the inner leaflet of plasma membranes. Many plasma membrane ion channels and ion transporters require PIP to function and can be turned off by signaling pathways that deplete PIP. This review discusses the dependence of ion channels on phosphoinositides and considers possible mechanisms by which PIP and analogues regulate ion channel activity.

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/content/journals/10.1146/annurev.biophys.37.032807.125859
2008-06-09
2024-06-25
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  • Article Type: Review Article
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