Cells in the immune and nervous systems communicate through informational synapses. The two-dimensional chemistry underlying the process of synapse formation is beginning to be explored using fluorescence imaging and mechanical techniques. Early analysis of two-dimensional kinetic rates (k and k) and equilibrium constants () provides a number of biological insights. First, there are two regimes for adhesion—one disordered with slow k and the other self-ordered with 104-fold faster k. Despite huge variation in two-dimensional k, the two-dimensional k is like k in solution, and two-dimensional k is more closely related to intrinsic properties of the interaction than the two-dimensional k. Thus difference in k can be used to set signaling thresholds. Early signaling complexes are compartmentalized to generate synergistic signaling domains. Immune antigen receptor components have a role in neural synapse editing. This suggests significant parallels in informational synapse formation based on common two-dimensional chemistry and signaling strategies.


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  • Article Type: Review Article
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