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Abstract

Abstract 

The vast majority of plant and animal viruses have RNA genomes. Viral gene expression and replication are controlled by -acting elements in the viral genome, which have been viewed conventionally as localized structures. However, recent research has altered this perception and provided compelling evidence for cooperative activity involving distantly positioned RNA elements. This chapter focuses on viral RNA elements that interact across hundreds or thousands of intervening nucleotides to control translation, genomic RNA synthesis, and subgenomic mRNA transcription. We discuss evidence supporting the existence and function of the interactions, and speculate on the regulatory roles that such long-distance interactions play in the virus life cycle. We emphasize viruses in the and families in which long-distance interactions are best characterized, but similar phenomena in other viruses are also discussed. Many more examples likely remain undiscovered.

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/content/journals/10.1146/annurev.phyto.44.070505.143353
2006-09-08
2024-06-24
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  • Article Type: Review Article
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