1932
0
  1. Home
  2. A-Z Publications
  3. Annual Review of Animal Biosciences
  4. Volume 3, 2015
  5. Article

Annual Review of Animal Biosciences

Volume 3, 2015

A New Medical Research Model: Ethically and Responsibly Advancing Health for Humans and Animals

Abstract

With the increasing use of genomics, computational analytics, emerging technologies, and personalized medicine, the possibility of a new research model is emerging. Using the clues from thousands of species living on our planet, scientists from many disciplines (medicine, veterinary medicine, wildlife) must collaborate, prioritize, and strategize on how to address causes of health and disease. Such clues should guide disease prevention, as well as the development of innovative, efficacious, and gentler therapies. Geographic and language barriers must be broken down, and scientists—even within a single academic, corporate, or government research site—must be vigilant in seeking the help of nonmedical disciplines of colleagues from whence answers might come. The public will become more interested in and demanding of such a model, desiring that all family members (humans and animals) have an opportunity for a long and healthy life. Above all, such activities will be humanely conducted with outcomes having the greatest chance for success.

Keyword(s): children, pets, science, welfare, well-being, wellness
Loading

Article metrics loading...

/content/journals/10.1146/annurev-animal-022114-110759
2015-02-16
2025-02-17
Loading full text...

Full text loading...

/deliver/fulltext/animal/3/1/annurev-animal-022114-110759.html?itemId=/content/journals/10.1146/annurev-animal-022114-110759&mimeType=html&fmt=ahah

Literature Cited

  1. Kaufman W. 1968. 1596–1650 Rene Descartes. Philosophic Classics: Bacon to Kant Kaufmann W. 21–80 Englewood Cliffs, NJ: Prentice-Hall [Google Scholar]
  2. Wilson SD. 2010. Animals and ethics. Internet Encyclopedia of Philosophy: A Peer-Reviewed Academic Resource http://www.iep.utm.edu/anim-eth/ [Google Scholar]
  3. Kean H. 1995. The ‘smooth cool men of science’: the feminist and social response to vivisection. Hist. Workshop J. 40:116–38 [Google Scholar]
  4. Ed. Encycl. Br. 2013. Sir William Maddock Bayliss. In Encyclopedia Britannica Online, updated Aug. 23. http://www.britannica.com/EBchecked/topic/56894/Sir-William-Maddock-Bayliss
  5. Natl. Anti-Vivisect. Soc. Who wants a Royal Commission on vivisection? http://www.navs.org.uk/about_vivisection/27/43/348/
  6. Smith D. 2002. In brief: rats, mice and birds excluded from Animal Welfare Act. Monit. Psychol. 33:714 [Google Scholar]
  7. Rollin BE. 2012. Ethics of medical research with animals: the moral status of invasive animal research. Hastings Cent. Rep. 42:61–6 http://animalresearch.thehastingscenter.org/report/the-moral-status-of-invasive-animal-research/ [Google Scholar]
  8. Int. Assoc. Study Pain 2014. IASP Guidelines for the Use of Animals in Research Washington, DC: Int. Assoc. Study Pain http://www.iasp-pain.org/Education/Content.aspx?ItemNumber=1217 [Google Scholar]
  9. World Organ. Anim. Health 2014. Animal welfare. Terrestrial Animal Health Code Article 7.1.1. Paris: World Organ. Anim. Health. http://www.oie.int/en/international-standard-setting/terrestrial-code/access-online/ [Google Scholar]
  10. Harrison R. 1964. Animal Machines London: Vincent Stuart Publ. [Google Scholar]
  11. Brambell FWR. 1965. Report of the Technical Committee to Enquire into the Welfare of Animals Kept Under Intensive Livestock Husbandry Systems. London: Her Majesty’s Station. Off. http://www.defra.gov.uk/fawc/about/five-freedoms/
  12. Begley S. 2011.Why almost everything you hear about medicine is wrong. Newsweek, Jan. 15
  13. Ganzert RR, Olson PN. 2012. A new paradigm for medical research, evidence-based policy and humane solutions. Spec. Rep., Am. Hum. Assoc. Res. Policy Inst. Am. Hum. Assoc. Washington, DC: [Google Scholar]
  14. Cuomo MI. 2012. A World Without Cancer: The Making of a New Cure and the Real Promise of Prevention New York: Rodale Inc. [Google Scholar]
  15. Leaf C. 2004. Why we’re losing the war on cancer. . Fortune, March 22, pp. 76–82, 84–86, 88 [Google Scholar]
  16. Dobson JM. 2013. Breed-predisposition to cancer in pedigree dogs. ISRN Vet. Sci. 2013:941275 [Google Scholar]
  17. Butler LM, Bonnett BN, Page RD. 2012. Epidemiology and the evidence-based medicine approach. Small Animal Clinical Oncology Withrow SJ, Vail DM, Page RD. 68–82 St. Louis, MO: Elsevier/Saunders [Google Scholar]
  18. Univ. Haifa. 2013. The naked mole rat’s secret to staying cancer free. Press Release, July 17
  19. Natl. Cancer Inst 2012. Fact Sheet: Prostate-Specific Antigen Test (PSA) Bethesda, MD: Natl. Cancer Inst. Natl. Inst. Health Reviewed July 24, 2012. http://www.cancer.gov/cancertopics/factsheet/detection/PSA [Google Scholar]
  20. Natl. Cancer Inst 2012. Fact Sheet: Mammograms Bethesda, MD: Natl. Cancer Inst. Natl. Inst. Health Reviewed July 24, 2012. http://www.cancer.gov/cancertopics/factsheet/detection/mammograms [Google Scholar]
  21. Makary M. 2014. The cost of chasing cancer. Time Feb. 27 [Google Scholar]
  22. Winslow R. 2012. When Plavix may not work. The Wall Street Journal, updated March 22. http://online.wsj.com/news/articles/SB10001424052748704841304575138091114112552
  23. Times Top 2014. Melamine—China tainted baby formula scandal. The New York Times March 17. http://topics.nytimes.com/top/reference/timestopics/subjects/m/melamine/index.html [Google Scholar]
  24. Levy S. 2007. Melamine death toll passes 8,000 pets. Newser May 4. http://www.newser.com/story/1927/melamine-death-toll-passes-8000-pets.html [Google Scholar]
  25. AAAS News 2013. U.S. Nobel Prize winners honored in D.C. AAAS News Nov. 25. http://membercentral.aaas.org/announcements/us-nobel-prize-winners-honored-dc [Google Scholar]
  26. Leshner AI. 2011. Rethinking the science system. Science 334:738 [Google Scholar]
  27. Leshner A. 2013. Maintaining science eminence. Science 341:820 [Google Scholar]
  28. Machovina B, Feeley KJ. 2014. Taking a bite out of biodiversity. Science 343:838 [Google Scholar]
  29. Livest. Environ. Dev 2006. Livestock’s Long Shadow: Environmental Issues and Options Rome: Food Agric. Organ http://www.fao.org/docrep/010/a0701e/a0701e00.htm [Google Scholar]
  30. Stokstad E. 2014. Ammonia pollution from farming may exact hefty health costs. Science 343:238 [Google Scholar]
  31. Tilman D, Fargione J, Wolff B, D’Antonio C, Dobson A et al. 2001. Forecasting agriculturally driven global environmental change. Science 292:281–84 [Google Scholar]
  32. Cure Child. Cancer 2010. Understanding the scope and challenges of childhood cancer. White Pap., Cure Child. Cancer, Atlanta, GA. http://www.curechildhoodcancer.org/wp-content/uploads/2010/06/CURE-State-of-Childhood-Cancer-White-Paper-04-09.pdf
  33. Cent. Dis. Control Prev 2013. Attention-Deficit/Hyperactivity Disorder (ADHD) Atlanta, GA: Cent. Dis. Control Prev Updated Nov. 21. http://www.cdc.gov/ncbddd/adhd/research.html [Google Scholar]
  34. Cent. Dis. Control Prev 2013. Key Findings: Trends in the Parent-Report of Health Care Provider-Diagnosis and Medication Treatment for ADHD: United States, 2003–2011 Atlanta, GA: Cent. Dis. Control Prev Updated Dec. 3. http://www.cdc.gov/ncbddd/adhd/features/key-findings-adhd72013.html [Google Scholar]
  35. Bloom B, Cohen RA, Freeman G. 2011. Summary health statistics for U.S. children: National Health Interview Survey, 2011. Vital Health Stat. 10254 http://www.cdc.gov/nchs/data/series/sr_10/sr10_254.pdf [Google Scholar]
  36. Natl. Counc. Pet Popul. Study Policy 1999. Exploring the Surplus Cat and Dog Problem New London, MN: Natl. Counc. Pet Popul. Study Policy http://petpopulation.org/exploring.pdf [Google Scholar]
  37. Pepling R. 2006. “Hypoallergenic” cats for sale, U.S. firm announces. National Geographic News June 9. http://news.nationalgeographic.com/news/2006/06/060609-allergies-cats.html [Google Scholar]
  38. Gaffin JM, Spergel JM, Boguniewicz M, Eichenfield LF, Paller AS et al. 2012. Effect of cat and daycare exposure on the risk of asthma in children with atopic dermatitis. Allergy Asthma Proc. 33:3282–88 [Google Scholar]
  39. Columbia Univ. Mailman Sch. Public Health 2008. Early life exposure to cats may reduce risk of childhood allergies and asthma symptoms. ScienceDaily May 22. http://www.sciencedaily.com/releases/2008/05/080520150717.htm [Google Scholar]
  40. Am. Acad. Allergy Asthma Immunol 2014. Pet Allergy Overview Milwaukee, WI: Am. Acad. Allergy Asthma Immunol Accessed March 18. http://www.aaaai.org/conditions-and-treatments/allergies/pet-allergy.aspx [Google Scholar]
  41. Yuill C. 2014. Taurine in Cats Los Angeles, CA: VCA Anim. Hosp Accessed March 18. http://www.vcahospitals.com/main/pet-health-information/article/animal-health/taurine-in-cats/3857 [Google Scholar]
  42. Banfield Pet Hosp 2014. Differences Between Cats and Dogs Portland, OR: Banfield Pet Hosp Accessed March 18. http://www.banfield.com/pet-health-resources/preventive-care/behavior/differences-between-cats-and-dogs [Google Scholar]
  43. Mladenovic D. 1998. Tylenol (acetaminophen) toxicosis in cats. ADDL Diagn. Forum Newsl Spring 1998. http://www.addl.purdue.edu/newsletters/1998/spring/acet.shtml [Google Scholar]
  44. Neff MW, Robertson KR, Wong AK, Safra N, Broman KW et al. 2004. Breed distribution and history of canine mdr1-1Δ, a pharmacogenetic mutation that marks the emergences of breeds from the collie lineage. Proc. Natl. Acad. Sci. USA 101:3211725–30 [Google Scholar]
  45. Coll. Vet. Med 2014. Multidrug Sensitivity in Dogs Pullman, WA: Wash. State Univ Updated March 12. http://www.vetmed.wsu.edu/depts-VCPL/ [Google Scholar]
  46. Coll. Vet. Med 2013. The Lyons’ Den Is Moving into the Tiger’s Lair Columbia: Coll. Vet. Med., Univ. Missouri http://vetmed.missouri.edu/news/Lyons2013.html [Google Scholar]
  47. de la Riva GT, Hart BL, Farver TB, Oberhauer AM, Messam LL et al. 2013. Neutering dogs: effects on joint disorders and cancers in Golden Retriever. PLOS ONE 8:2e55937 [Google Scholar]
  48. Byers KG, Savaiano DA. 2005. The myth of increased lactose intolerance in African-Americans. J. Am. Coll. Nutr 24:6569S–73S [Google Scholar]
  49. Yasuda SU, Zhang L, Huang S-M. 2008. The role of ethnicity in variability in response to drugs: focus on clinical pharmacology studies. Clin. Pharmacol. Ther. 84:3417–23 [Google Scholar]
  50. Leaf C. 2013. Opinion pages: Do clinical trials work?. The New York Times July 13. http://www.nytimes.com/2013/07/14/opinion/sunday/do-clinical-trials-work.html?pagewanted=all&_r=0 [Google Scholar]
  51. Cantor E, Smith L. 2013. Rethinking science funding: Bronze Age Cyprus and Chinese auto shows might not be the kind of high priority research topics that need federal cash. USA Today Sept. 30 [Google Scholar]
  52. Newport F. 2013. Congressional approval sinks to record low. Gallup Polit Nov. 12. http://www.gallup.com/poll/165809/congressional-approval-sinks-record-low.aspx [Google Scholar]
  53. Brown P. 2013. Entrepreneurs can save the world. Special Issue. Forbes Dec. 2 [Google Scholar]
  54. Vance A. 2014. Would you pay $1,000 to find out how you might die? Bloomberg Businessweek, Jan. 20–26. 54–57 [Google Scholar]
  55. Hayden EC. 2014. The $1,000 genome. Nature 507:7492294–95 [Google Scholar]
  56. Wojcicki A. 2013. 23AndMe provides an update regarding FDA’s review. 23andMe (blog), Dec. 5. http://blog.23andme.com/news/23andme-provides-an-update-regarding-fdas-review/ [Google Scholar]
  57. Kaiser Health News 2014. New Rule Allows Patients Direct Access to Lab Results Menlo Park, CA: Kaiser Health News http://www.kaiserhealthnews.org/Daily-Reports/2014/February/04/new-patient-access-rules.aspx [Google Scholar]
  58. Am. Hum. Assoc 2014. Canines and Childhood Cancer (CCC): Examining the Effects of Therapy Dogs with Childhood Cancer Patients and Their Families Washington, DC: Am. Hum. Assoc http://www.americanhumane.org/interaction/programs/animal-assisted-therapy/canines-and-childhood-cancer.html [Google Scholar]
  59. Natterson-Horowitz B. 2012. Zoobiquity: What Animals Can Teach Us About Health and the Science of Healing New York: Random House [Google Scholar]
  60. Szabo L. 2011. Girls hit puberty earlier than ever, and doctors aren’t sure why. USA Today April 10. Updated April 14. http://usatoday30.usatoday.com/news/health/wellness/story/2011/04/Girls-hit-puberty-earlier-than-ever-and-doctors-arent-sure-why/45989054/1 [Google Scholar]
  61. Kristof N. 2012. How chemicals affect us. The New York Times May 2. http://www.nytimes.com/2012/05/03/opinion/kristof-how-chemicals-change-us.html?_r=0 [Google Scholar]
/content/journals/10.1146/annurev-animal-022114-110759
Loading
A New Medical Research Model: Ethically and Responsibly Advancing Health for Humans and Animals
Annual Review of Animal Biosciences 3, 265 (2015); https://doi.org/10.1146/annurev-animal-022114-110759
/content/journals/10.1146/annurev-animal-022114-110759
/content/journals/10.1146/annurev-animal-022114-110759
Loading

Data & Media loading...

  • Article Type: Review Article

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error