The Critical Roles of Early Development, Stress, and Environment in the Course of Psychosis

Literature Cited

1. Abel K, Heuvelman H, Jörgensen L, Magnusson C, Wicks S et al. 2014. Severe bereavement stress during the prenatal and childhood periods and risk of psychosis in later life: population based cohort study. BMJ 348:f7679
   [Google Scholar]
2. Aguilera G. 1998. Corticotropin releasing hormone, receptor regulation and the stress response. Trends Endocrinol. Metab. 9:329–36
   [Google Scholar]
3. Akün E, Durak Batigün A, Devrimci Özgüven H, Baskak B 2018. Positive symptoms and perceived parental acceptance-rejection in childhood: the moderating roles of socioeconomic status and gender. Turk. J. Psychiatry 29:109–15
   [Google Scholar]
4. Anderson K, Edwards J. 2020. Age at migration and the risk of psychotic disorders: a systematic review and meta-analysis. Acta Psychiatr. Scand. 141:410–20
   [Google Scholar]
5. Bell CJ, Foulds JA, Horwood LJ, Mulder RT, Boden JM. 2019. Childhood abuse and psychotic experiences in adulthood: findings from a 35-year longitudinal study. Br. J. Psychiatry 214:153–58
   [Google Scholar]
6. Bell IH, Lim MH, Rossell SL, Thomas N. 2017. Ecological momentary assessment and intervention in the treatment of psychotic disorders: a systematic review. Psychiatr. Serv. 68:1172–81
   [Google Scholar]
7. Bell KL, Purcell JB, Harnett NG, Goodman AM, Mrug S et al. 2021. White matter microstructure in the young adult brain varies with neighborhood disadvantage in adolescence. Neuroscience 466:162–72
   [Google Scholar]
8. Belsky J, Ruttle PL, Boyce WT, Armstrong JM, Essex MJ. 2015. Early adversity, elevated stress physiology, accelerated sexual maturation, and poor health in females. Dev. Psychol. 51:816–22
   [Google Scholar]
9. Belsky J, Schlomer GL, Ellis BJ. 2012. Beyond cumulative risk: distinguishing harshness and unpredictability as determinants of parenting and early life history strategy. Dev. Psychol. 48:662–73
   [Google Scholar]
10. Bhana A 2010. Middle childhood and pre-adolescence. Promoting Mental Health in Scarce-Resource Contexts: Emerging Evidence and Practice I Petersen, A Bhana, AJ Flisher, L Swartz, L Richter 124–42 Cape Town, S. Afr: HSRC Press
    [Google Scholar]
11. Björkenstam E, Cheng S, Burström B, Pebley AR, Björkenstam C, Kosidou K. 2017. Association between income trajectories in childhood and psychiatric disorder: a Swedish population-based study. J. Epidemiol. Community Health 71:648–54
    [Google Scholar]
12. Blakemore SJ, Burnett S, Dahl RE. 2010. The role of puberty in the developing adolescent brain. Hum. . Brain Mapp. 31:926–33
    [Google Scholar]
13. Bolhuis K, Koopman-Verhoeff M, Blanken L, Cibrev D, Jaddoe V et al. 2018. Psychotic-like experiences in pre-adolescence: What precedes the antecedent symptoms of severe mental illness?. Acta. Psychiatr. Scand. 138:15–25
    [Google Scholar]
14. Brito NH, Fifer WP, Myers MM, Elliott AJ, Noble KG. 2016. Associations among family socioeconomic status, EEG power at birth, and cognitive skills during infancy. Dev. Cogn. Neurosci. 19:144–51
    [Google Scholar]
15. Brito NH, Noble KG. 2014. Socioeconomic status and structural brain development. Front. Neurosci. 8:276
    [Google Scholar]
16. Brito NH, Noble KG. 2018. The independent and interacting effects of socioeconomic status and dual-language use on brain structure and cognition. Dev. Sci. 21:e12688
    [Google Scholar]
17. Bronfenbrenner U 1992. Ecological systems theory. Six Theories of Child Development: Revised Formulations and Current Issues R Vasta 187–249 London: Jessica Kingsley Publ.
    [Google Scholar]
18. Burkhard C, Cicek S, Barzilay R, Radhakrishnan R, Guloksuz S. 2021. Need for ethnic and population diversity in psychosis research. Schizophr. Bull. 47:889–95
    [Google Scholar]
19. Callicott JH, Mattay VS, Verchinski BA, Marenco S, Egan MF, Weinberger DR. 2003. Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down. Am. J. Psychiatry 160:2209–15
    [Google Scholar]
20. Cannon TD, Rosso IM, Hollister JM, Bearden CE, Sanchez LE, Hadley T. 2000. A prospective cohort study of genetic and perinatal influences in the etiology of schizophrenia. Schizophr. Bull. 26:351–66
    [Google Scholar]
21. Carpenter WT Jr., Kirkpatrick B. 1988. The heterogeneity of the long-term course of schizophrenia. Schizophr. Bull. 14:645–52
    [Google Scholar]
22. Chang L, Lu HJ, Lansford JE, Skinner AT, Bornstein MH et al. 2019. Environmental harshness and unpredictability, life history, and social and academic behavior of adolescents in nine countries. Dev. Psychol. 55:890–903
    [Google Scholar]
23. Chin-Lun Hung G, Hahn J, Alamiri B, Buka SL, Goldstein JM et al. 2015. Socioeconomic disadvantage and neural development from infancy through early childhood. Int. J. Epidemiol. 44:1889–99
    [Google Scholar]
24. Cicchetti D, Rogosch FA. 1996. Equifinality and multifinality in developmental psychopathology. Dev. Psychopathol. 8:597–600
    [Google Scholar]
25. Clemmensen L, Van Os J, Drukker M, Munkholm A, Rimvall M et al. 2016. Psychotic experiences and hyper-theory-of-mind in preadolescence–a birth cohort study. Psychol. Med. 46:87–101
    [Google Scholar]
26. Cohodes EM, Kitt ER, Baskin-Sommers A, Gee DG. 2021. Influences of early-life stress on frontolimbic circuitry: harnessing a dimensional approach to elucidate the effects of heterogeneity in stress exposure. Dev. Psychobiol. 63:153–72
    [Google Scholar]
27. Colich NL, Rosen ML, Williams ES, McLaughlin KA. 2020. Biological aging in childhood and adolescence following experiences of threat and deprivation: a systematic review and meta-analysis. Psychol. Bull. 146:721–64
    [Google Scholar]
28. Corcoran C, Walker E, Huot R, Mittal V, Tessner K et al. 2003. The stress cascade and schizophrenia: etiology and onset. Schizophr. Bull. 29:671–92
    [Google Scholar]
29. Cullen AE, Fisher HL, Gullet N, Fraser ER, Roberts RE et al. 2021. Cortisol levels in childhood associated with emergence of attenuated psychotic symptoms in early adulthood. Biol. Psychiatry 91:226–35
    [Google Scholar]
30. Cunningham MG, Bhattacharyya S, Benes FM. 2002. Amygdalo-cortical sprouting continues into early adulthood: implications for the development of normal and abnormal function during adolescence. J. Comp. Neurol. 453:116–30
    [Google Scholar]
31. Damme KS, Ristanovic I, Vargas T, Mittal VA. 2020. Timing of menarche and abnormal hippocampal connectivity in youth at clinical-high risk for psychosis. Psychoneuroendocrinology 117:104672
    [Google Scholar]
32. Daskalakis NP, Oitzl MS, Schächinger H, Champagne DL, de Kloet ER. 2012. Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model of early-life adversity. Physiol. Behav. 106:707–21
    [Google Scholar]
33. Dauvermann M, Donohoe G. 2019. Cortisol stress response in psychosis from the high-risk to the chronic stage: a systematic review. Irish J. Psychol. Med. 36:305–15
    [Google Scholar]
34. Debowska A, Willmott D, Boduszek D, Jones AD. 2017. What do we know about child abuse and neglect patterns of co-occurrence? A systematic review of profiling studies and recommendations for future research. Child Abuse Negl. 70:100–11
    [Google Scholar]
35. Dempster K, Norman R, Théberge J, Densmore M, Schaefer B, Williamson P. 2017. Cognitive performance is associated with gray matter decline in first-episode psychosis. Psychiatry Res. Neuroimaging 264:46–51
    [Google Scholar]
36. Deoni SC, Mercure E, Blasi A, Gasston D, Thomson A et al. 2011. Mapping infant brain myelination with magnetic resonance imaging. J. Neurosci. 31:784–91
    [Google Scholar]
37. DeRosse P, Barber AD. 2021. Overlapping neurobiological substrates for early-life stress and resilience to psychosis. Biol. Psychiatry Cogn. Neurosci. Neuroimaging 6:144–53
    [Google Scholar]
38. DeRosse P, Ikuta T, Peters BD, Karlsgodt KH, Szeszko PR, Malhotra AK. 2014. Adding insult to injury: childhood and adolescent risk factors for psychosis predict lower fractional anisotropy in the superior longitudinal fasciculus in healthy adults. Psychiatry Res. Neuroimaging 224:296–302
    [Google Scholar]
39. DeVylder JE, Ben-David S, Schobel S, Kimhy D, Malaspina D, Corcoran C. 2013. Temporal association of stress sensitivity and symptoms in individuals at clinical high risk for psychosis. Psychol. Med. 43:259–68
    [Google Scholar]
40. DeVylder JE, Kelleher I, Lalane M, Oh H, Link BG, Koyanagi A. 2018. Association of urbanicity with psychosis in low-and middle-income countries. JAMA Psychiatry 75:678–86
    [Google Scholar]
41. Dickinson D, Iannone VN, Wilk CM, Gold JM. 2004. General and specific cognitive deficits in schizophrenia. Biol. Psychiatry 55:826–33
    [Google Scholar]
42. Dickinson D, Pratt DN, Giangrande EJ, Grunnagle M, Orel J et al. 2018. Attacking heterogeneity in schizophrenia by deriving clinical subgroups from widely available symptom data. Schizophr. Bull. 44:101–13
    [Google Scholar]
43. Dorn LD. 2006. Measuring puberty. J. Adolesc. Health 39:625–26
    [Google Scholar]
44. Elenkov IJ, Webster EL, Torpy DJ, Chrousos GP. 1999. Stress, corticotropin-releasing hormone, glucocorticoids, and the immune/inflammatory response: acute and chronic effects. Ann. N.Y. Acad. Sci. 876:1–13
    [Google Scholar]
45. Evans GW, Li D, Whipple SS. 2013. Cumulative risk and child development. Psychol. Bull. 139:1342–96
    [Google Scholar]
46. Farrow P, Simmons JG, Pozzi E, Díaz-Arteche C, Richmond S et al. 2020. Associations between early life stress and anterior pituitary gland volume development during late childhood. Psychoneuroendocrinology 122:104868
    [Google Scholar]
47. Feinberg I. 1982. Schizophrenia: caused by a fault in programmed synaptic elimination during adolescence?. J. Psychiatr. Res. 17:319–34
    [Google Scholar]
48. Fields A, Harmon C, Lee Z, Louie JY, Tottenham N. 2021. Parent's anxiety links household stress and young children's behavioral dysregulation. Dev. Psychobiol. 63:16–30
    [Google Scholar]
49. Finch BK, Do DP, Heron M, Bird C, Seeman T, Lurie N. 2010. Neighborhood effects on health: concentrated advantage and disadvantage. Health Place 16:1058–60
    [Google Scholar]
50. Fowles D. 1992. Schizophrenia: diathesis-stress revisited. Annu. Rev. Psychol. 43:303–36
    [Google Scholar]
51. Fusar-Poli P, Cappucciati M, Borgwardt S, Woods SW, Addington J et al. 2016. Heterogeneity of psychosis risk within individuals at clinical high risk: a meta-analytical stratification. JAMA Psychiatry 73:113–20
    [Google Scholar]
52. Fusar-Poli P, Tantardini M, De Simone S, Ramella-Cravaro V, Oliver D et al. 2017. Deconstructing vulnerability for psychosis: meta-analysis of environmental risk factors for psychosis in subjects at ultra high-risk. Eur. Psychiatry 40:65–75
    [Google Scholar]
53. Ganzel BL, Kim P, Gilmore H, Tottenham N, Temple E 2013. Stress and the healthy adolescent brain: evidence for the neural embedding of life events. Dev. Psychopathol. 25:879–89
    [Google Scholar]
54. Gao W, Alcauter S, Elton A, Hernandez-Castillo CR, Smith JK et al. 2015. Functional network development during the first year: relative sequence and socioeconomic correlations. Cereb. Cortex 25:2919–28
    [Google Scholar]
55. Gard AM, Maxwell AM, Shaw DS, Mitchell C, Brooks-Gunn J et al. 2021. Beyond family-level adversities: exploring the developmental timing of neighborhood disadvantage effects on the brain. Dev. Sci. 24:e12985
    [Google Scholar]
56. Gee DG, Gabard-Durnam LJ, Flannery J, Goff B, Humphreys KL et al. 2013. Early developmental emergence of human amygdala–prefrontal connectivity after maternal deprivation. PNAS 110:15638–43
    [Google Scholar]
57. Gee DG, Karlsgodt KH, van Erp TG, Bearden CE, Lieberman MD et al. 2012. Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: a preliminary study. Schizophr. Res. 134:1–9
    [Google Scholar]
58. Gilmore JH, Knickmeyer RC, Gao W. 2018. Imaging structural and functional brain development in early childhood. Nat. Rev. Neurosci. 19:123–37
    [Google Scholar]
59. Haddad L, Schäfer A, Streit F, Lederbogen F, Grimm O et al. 2015. Brain structure correlates of urban upbringing, an environmental risk factor for schizophrenia. Schizophr. Bull. 41:115–22
    [Google Scholar]
60. Hanson JL, Hair N, Shen DG, Shi F, Gilmore JH et al. 2013. Family poverty affects the rate of human infant brain growth. PLOS ONE 8:e80954
    [Google Scholar]
61. Hastings PD, Serbin LA, Bukowski W, Helm JL, Stack DM et al. 2020. Predicting psychosis-spectrum diagnoses in adulthood from social behaviors and neighborhood contexts in childhood. Dev. Psychopathol. 32:465–79
    [Google Scholar]
62. Horton LE, Tarbox SI, Olino TM, Haas GL. 2015. Trajectories of premorbid childhood and adolescent functioning in schizophrenia-spectrum psychoses: a first-episode study. Psychiatry Res. 227:339–46
    [Google Scholar]
63. Hyde LW, Gard AM, Tomlinson RC, Burt SA, Mitchell C, Monk CS. 2020. An ecological approach to understanding the developing brain: examples linking poverty, parenting, neighborhoods, and the brain. Am. Psychol. 75:1245
    [Google Scholar]
64. Insel TR. 2010. Rethinking schizophrenia. Nature 468:187–93
    [Google Scholar]
65. Kaess M, Whittle S, O'Brien-Simpson L, Allen NB, Simmons JG 2018. Childhood maltreatment, pituitary volume and adolescent hypothalamic-pituitary-adrenal axis – evidence for a maltreatment-related attenuation. Psychoneuroendocrinology 98:39–45
    [Google Scholar]
66. Karcher NR, Schiffman J, Barch DM. 2021. Environmental risk factors and psychotic-like experiences in children aged 9–10. J. Am. Acad. Child Adolesc. Psychiatry 60:490–500
    [Google Scholar]
67. Kelly S, Jahanshad N, Zalesky A, Kochunov P, Agartz I et al. 2018. Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group. Mol. Psychiatry 23:1261–69
    [Google Scholar]
68. Kesek A, Zelazo PD, Lewis MD 2008. The development of executive cognitive function and emotion regulation in adolescence. Adolescent Emotional Development and the Emergence of Depressive Disorders NB Allen, LB Sheeber 135–55 Cambridge, UK: Cambridge Univ. Press
    [Google Scholar]
69. Khundrakpam BS, Reid A, Brauer J, Carbonell F, Lewis J et al. 2013. Developmental changes in organization of structural brain networks. Cereb. Cortex 23:2072–85
    [Google Scholar]
70. Knickmeyer RC, Gouttard S, Kang C, Evans D, Wilber K et al. 2008. A structural MRI study of human brain development from birth to 2 years. J. Neurosci. 28:12176–82
    [Google Scholar]
71. Knickmeyer RC, Xia K, Lu Z, Ahn M, Jha SC et al. 2017. Impact of demographic and obstetric factors on infant brain volumes: a population neuroscience study. Cereb. Cortex 27:5616–25
    [Google Scholar]
72. Krogsrud SK, Fjell AM, Tamnes CK, Grydeland H, Mork L et al. 2016. Changes in white matter microstructure in the developing brain—a longitudinal diffusion tensor imaging study of children from 4 to 11 years of age. NeuroImage 124:473–86
    [Google Scholar]
73. Lardinois M, Lataster T, Mengelers R, Van Os J, Myin-Germeys I. 2011. Childhood trauma and increased stress sensitivity in psychosis. Acta Psychiatr. Scand. 123:28–35
    [Google Scholar]
74. Lawson GM, Camins JS, Wisse L, Wu J, Duda JT et al. 2017. Childhood socioeconomic status and childhood maltreatment: distinct associations with brain structure. PLOS ONE 12:e0175690
    [Google Scholar]
75. Lederbogen F, Kirsch P, Haddad L, Streit F, Tost H et al. 2011. City living and urban upbringing affect neural social stress processing in humans. Nature 474:498–501
    [Google Scholar]
76. Lee KW, Chan KW, Chang WC, Lee EHM, Hui CLM, Chen EYH. 2016. A systematic review on definitions and assessments of psychotic-like experiences. Early Interv. Psychiatry 10:3–16
    [Google Scholar]
77. Li Z, Liu S, Hartman S, Belsky J. 2018. Interactive effects of early-life income harshness and unpredictability on children's socioemotional and academic functioning in kindergarten and adolescence. Dev. Psychol. 54:2101–12
    [Google Scholar]
78. LoPilato AM, Goines K, Addington J, Bearden CE, Cadenhead KS et al. 2019. Impact of childhood adversity on corticolimbic volumes in youth at clinical high-risk for psychosis. Schizophr. Res. 213:48–55
    [Google Scholar]
79. Luby J, Belden A, Botteron K, Marrus N, Harms MP et al. 2013. The effects of poverty on childhood brain development: the mediating effect of caregiving and stressful life events. JAMA Pediatrics 167:1135–42
    [Google Scholar]
80. Lyall AE, Shi F, Geng X, Woolson S, Li G et al. 2015. Dynamic development of regional cortical thickness and surface area in early childhood. Cereb. Cortex 25:2204–12
    [Google Scholar]
81. Mackey AP, Finn AS, Leonard JA, Jacoby-Senghor DS, West MR et al. 2015. Neuroanatomical correlates of the income-achievement gap. Psychol. Sci. 26:925–33
    [Google Scholar]
82. Maninger N, Wolkowitz OM, Reus VI, Epel ES, Mellon SH. 2009. Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS). Front. Neuroendocrinol. 30:65–91
    [Google Scholar]
83. Marceau K, Ruttle PL, Shirtcliff EA, Essex MJ, Susman EJ. 2015. Developmental and contextual considerations for adrenal and gonadal hormone functioning during adolescence: implications for adolescent mental health. Dev. Psychobiol. 57:742–68
    [Google Scholar]
84. Marek S, Tervo-Clemmens B, Calabro FJ, Montez DF, Kay BP et al. 2022. Reproducible brain-wide association studies require thousands of individuals. Nature 603:654–60
    [Google Scholar]
85. Marsh R, Gerber AJ, Peterson BS. 2008. Neuroimaging studies of normal brain development and their relevance for understanding childhood neuropsychiatric disorders. J. Am. Acad. Child Adolesc. Psychiatry 47:1233–51
    [Google Scholar]
86. McCutcheon RA, Krystal JH, Howes OD. 2020. Dopamine and glutamate in schizophrenia: biology, symptoms and treatment. World Psychiatry 19:15–33
    [Google Scholar]
87. McEwen BS, Nasca C, Gray JD. 2016. Stress effects on neuronal structure: hippocampus, amygdala, and prefrontal cortex. Neuropsychopharmacology 41:3–23
    [Google Scholar]
88. McGlashan TH, Hoffman RE. 2000. Schizophrenia as a disorder of developmentally reduced synaptic connectivity. Arch. Gen. Psychiatry 57:637–48
    [Google Scholar]
89. McLaughlin KA, Sheridan MA, Lambert HK. 2014. Childhood adversity and neural development: deprivation and threat as distinct dimensions of early experience. Neurosci. Biobehav. Rev. 47:578–91
    [Google Scholar]
90. Mendle J, Harden KP, Brooks-Gunn J, Graber JA. 2010. Development's tortoise and hare: pubertal timing, pubertal tempo, and depressive symptoms in boys and girls. Dev. Psychol. 46:1341
    [Google Scholar]
91. Merz EC, Maskus EA, Melvin SA, He X, Noble KG. 2020. Socioeconomic disparities in language input are associated with children's language-related brain structure and reading skills. Child Dev. 91:846–60
    [Google Scholar]
92. Millman ZB, Roemer C, Vargas TG, Schiffman J, Mittal V, Gold JM. 2022. Neuropsychological performance among individuals at clinical high-risk for psychosis vs putatively low-risk peers with other psychopathology: a systematic review and meta-analysis. Schizophr. Bull. 48:999–1010
    [Google Scholar]
93. Mills KL, Lalonde F, Clasen LS, Giedd JN, Blakemore S-J. 2014. Developmental changes in the structure of the social brain in late childhood and adolescence. Soc. Cogn. Affect. Neurosci. 9:123–31
    [Google Scholar]
94. Mills KL, Siegmund KD, Tamnes CK, Ferschmann L, Wierenga LM et al. 2021. Inter-individual variability in structural brain development from late childhood to young adulthood. NeuroImage 242:118450
    [Google Scholar]
95. Mittal VA, Walker EF. 2019. Advances in the neurobiology of stress and psychosis. Schizophr. Res. 213:1–5
    [Google Scholar]
96. Mondelli V, Pariante CM. 2008. Hypothalamus-pituitary-adrenal (HPA) axis and metabolic abnormalities in first-episode psychosis. Curr. Psychiatry Rev. 4:185–89
    [Google Scholar]
97. Moreno D, Moreno-Iñiguez M, Vigil D, Castro-Fornieles J, Ortuño F et al. 2009. Obstetric complications as a risk factor for first psychotic episodes in childhood and adolescence. Eur. Child Adolesc. Psychiatry 18:180–84
    [Google Scholar]
98. Morland K, Wing S, Roux AD, Poole C. 2002. Neighborhood characteristics associated with the location of food stores and food service places. Am. J. Prev. Med. 22:23–29
    [Google Scholar]
99. Murray R, Bora E, Modinos G, Vernon A. 2022. Schizophrenia: a developmental disorder with a risk of non-specific but avoidable decline. Schizophr. Res. 243:181–86
    [Google Scholar]
100. Nelson CA III, Gabard-Durnam LJ 2020. Early adversity and critical periods: neurodevelopmental consequences of violating the expectable environment. Trends Neurosci. 43:133–43
     [Google Scholar]
101. Newbury J, Arseneault L, Caspi A, Moffitt TE, Odgers CL, Fisher HL. 2016. Why are children in urban neighborhoods at increased risk for psychotic symptoms? Findings from a UK longitudinal cohort study. Schizophrenia Bull. 42:1372–83
     [Google Scholar]
102. Nielsen M, Haun D, Kärtner J, Legare CH. 2017. The persistent sampling bias in developmental psychology: a call to action. J. Exp. Child. Psychol. 162:31–38
     [Google Scholar]
103. Noble KG, Houston SM, Kan E, Sowell ER. 2012. Neural correlates of socioeconomic status in the developing human brain. Dev. Sci. 15:516–27
     [Google Scholar]
104. Pätzold I, Myin-Germeys I, Schick A, Nelson B, Velthorst E et al. 2021. Stress reactivity as a putative mechanism linking childhood trauma with clinical outcomes in individuals at ultra-high-risk for psychosis: findings from the EU-GEI High Risk Study. Epidemiol. Psychiatr. Sci. 30:e40
     [Google Scholar]
105. Pollak SD, Cicchetti D, Hornung K, Reed A. 2000. Recognizing emotion in faces: developmental effects of child abuse and neglect. Dev. Psychol. 36:679–88
     [Google Scholar]
106. Pries L-K, Erzin G, Rutten BP, van Os J, Guloksuz S. 2021. Estimating aggregate environmental risk score in psychiatry: the exposome score for schizophrenia. Front. Psychiatry 12:671334
     [Google Scholar]
107. Pries L-K, Lage-Castellanos A, Delespaul P, Kenis G, Luykx JJ et al. 2019. Estimating exposome score for schizophrenia using predictive modeling approach in two independent samples: the results from the EUGEI study. Schizophr. Bull. 45:960–65
     [Google Scholar]
108. Pruessner M, Cullen AE, Aas M, Walker EF. 2017. The neural diathesis-stress model of schizophrenia revisited: an update on recent findings considering illness stage and neurobiological and methodological complexities. Neurosci. Biobehav. Rev. 73:191–218
     [Google Scholar]
109. Raizada RD, Kishiyama MM. 2010. Effects of socioeconomic status on brain development, and how cognitive neuroscience may contribute to leveling the playing field. Front. Hum. Neurosci. 4:3
     [Google Scholar]
110. Ramphal B, Whalen DJ, Kenley JK, Yu Q, Smyser CD et al. 2020. Brain connectivity and socioeconomic status at birth and externalizing symptoms at age 2 years. Dev. Cogn. Neurosci. 45:100811
     [Google Scholar]
111. Ramsay CE, Flanagan P, Gantt S, Broussard B, Compton MT. 2011. Clinical correlates of maltreatment and traumatic experiences in childhood and adolescence among predominantly African American, socially disadvantaged, hospitalized, first-episode psychosis patients. Psychiatry Res. 188:343–49
     [Google Scholar]
112. Rapado-Castro M, Whittle S, Pantelis C, Thompson A, Nelson B et al. 2020. Does cortical brain morphology act as a mediator between childhood trauma and transition to psychosis in young individuals at ultra-high risk?. Schizophr. Res. 224:116–25
     [Google Scholar]
113. Remer T, Boye KR, Hartmann MF, Wudy SA. 2005. Urinary markers of adrenarche: reference values in healthy subjects, aged 3–18 years. J. Clin. Endocrinol. Metab. 90:2015–21
     [Google Scholar]
114. Richardson L, Hameed Y, Perez J, Jones PB, Kirkbride JB. 2018. Association of environment with the risk of developing psychotic disorders in rural populations: findings from the social epidemiology of psychoses in East Anglia study. JAMA Psychiatry 75:75–83
     [Google Scholar]
115. Ripke S, Neale BM, Corvin A, Walters JT, Farh K-H et al. 2014. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511:421–27
     [Google Scholar]
116. Ristanovic I, Vargas T, Cowan HR, Mittal VA. 2020. Consistent exposure to psychosocial stressors and progressive intolerance to stress in individuals at clinical high risk for psychosis. Schizophr. Bull. Open 1:sgaa004
     [Google Scholar]
117. Rodrigues SM, LeDoux JE, Sapolsky RM. 2009. The influence of stress hormones on fear circuitry. Annu. Rev. Neurosci. 32:289–313
     [Google Scholar]
118. Rosenthal D. 1970. Genetic Theory and Abnormal Behavior. New York: McGraw-Hill
119. Saunders TS, Mondelli V, Cullen AE. 2019. Pituitary volume in individuals at elevated risk for psychosis: a systematic review and meta-analysis. Schizophr. Res. 213:23–31
     [Google Scholar]
120. Schofield P, Das-Munshi J, Webb RT, Horsdal HT, Pedersen CB, Agerbo E. 2021. Lack of fit with the neighbourhood social environment as a risk factor for psychosis – a national cohort study. Psychol. Med. In press. https://www.doi.org/10.1017/S0033291721002233
     [Crossref] [Google Scholar]
121. Shah S, Mackinnon A, Galletly C, Carr V, McGrath JJ et al. 2014. Prevalence and impact of childhood abuse in people with a psychotic illness. Data from the second Australian national survey of psychosis. Schizophr. Res. 159:20–26
     [Google Scholar]
122. Simcock G, Kildea S, Elgbeili G, Laplante DP, Stapleton H et al. 2016. Age-related changes in the effects of stress in pregnancy on infant motor development by maternal report: the Queensland Flood Study. Dev. Psychobiol. 58:640–59
     [Google Scholar]
123. Smith KE, Pollak SD. 2021. Rethinking concepts and categories for understanding the neurodevelopmental effects of childhood adversity. Perspect. Psychol. Sci. 16:67–93
     [Google Scholar]
124. Solmi F, Colman I, Weeks M, Lewis G, Kirkbride JB. 2017. Trajectories of neighborhood cohesion in childhood, and psychotic and depressive symptoms at age 13 and 18 years. J. Am. Acad. Child Adolesc. Psychiatry 56:570–77
     [Google Scholar]
125. Staff RT, Murray AD, Ahearn TS, Mustafa N, Fox HC, Whalley LJ. 2012. Childhood socioeconomic status and adult brain size: childhood socioeconomic status influences adult hippocampal size. Ann. Neurol. 71:653–60
     [Google Scholar]
126. Stanton KJ, Denietolis B, Goodwin BJ, Dvir Y. 2020. Childhood trauma and psychosis: an updated review. Child Adolesc. Psychiatr. Clin. 29:115–29
     [Google Scholar]
127. Steenkamp LR, Tiemeier H, Bolhuis K, Hillegers MH, Kushner SA, Blanken LM. 2021. Peer-reported bullying, rejection and hallucinatory experiences in childhood. Acta Psychiatr. Scand. 143:503–12
     [Google Scholar]
128. Sullivan SA, Kounali D, Cannon M, David AS, Fletcher PC et al. 2020. A population-based cohort study examining the incidence and impact of psychotic experiences from childhood to adulthood, and prediction of psychotic disorder. Am. J. Psychiatry 177:308–17
     [Google Scholar]
129. Tienari P, Sorri A, Lahti I, Naarala M, Wahlberg K et al. 1985. The Finnish adoptive family study of schizophrenia. Yale J. Biol. Med. 58:227–37
     [Google Scholar]
130. Tomalski P, Moore DG, Ribeiro H, Axelsson EL, Murphy E et al. 2013. Socioeconomic status and functional brain development–associations in early infancy. Dev. Sci. 16:676–87
     [Google Scholar]
131. Trotman HD, Holtzman CW, Ryan AT, Shapiro DI, MacDonald AN et al. 2013. The development of psychotic disorders in adolescence: a potential role for hormones. Horm. Behav. 64:411–19
     [Google Scholar]
132. Tsuang MT, Lyons MJ, Faraone SV. 1990. Heterogeneity of schizophrenia. Br. J. Psychiatry 156:17–26
     [Google Scholar]
133. Turner S, Harvey C, Hayes L, Castle D, Galletly C et al. 2020. Childhood adversity and clinical and psychosocial outcomes in psychosis. Epidemiol. Psychiatr. Sci. 29:e78
     [Google Scholar]
134. Ursache A, Noble KG. 2016. Socioeconomic status, white matter, and executive function in children. Brain Behav. 6:e00531
     [Google Scholar]
135. Vanderbilt-Adriance E, Shaw DS. 2008. Protective factors and the development of resilience in the context of neighborhood disadvantage. J. Abnorm. Child Psychol. 36:887–901
     [Google Scholar]
136. Vargas T. 2022. Systematic environmental factors, neural correlates and psychosis vulnerability Ph.D. Diss. Northwest. Univ.
137. Vargas T, Conley RE, Mittal VA. 2020. Chronic stress, structural exposures and neurobiological mechanisms: a stimulation, discrepancy and deprivation model of psychosis. Int. Rev. Neurobiol. 152:41–69
     [Google Scholar]
138. Vargas T, Damme KS, Osborne KJ, Mittal VA. 2021. Differentiating kinds of systemic stressors with relation to psychotic-like experiences in late childhood and early adolescence: the stimulation, discrepancy, and deprivation model of psychosis. Clin. Psychol. Sci. 10:291–309
     [Google Scholar]
139. Vargas T, Mittal VA. 2018. Issues affecting reliable and valid assessment of early life stressors in psychosis. Schizophr. Res. 192:465–66
     [Google Scholar]
140. Vargas T, Zou DS, Conley RE, Mittal VA. 2019. Assessing developmental environmental risk factor exposure in clinical high risk for psychosis individuals: preliminary results using the individual and structural exposure to stress in psychosis-risk states scale. J. Clin. Med. 8:994
     [Google Scholar]
141. Vargas TG, Damme KSF, Mittal VA. 2022. Differentiating distinct and converging neural correlates of types of systemic environmental exposures. Hum. Brain Mapp. 43:2232–48
     [Google Scholar]
142. Vargas TG, Mittal VA. 2021. Testing whether implicit emotion regulation mediates the association between discrimination and symptoms of psychopathology in late childhood: an RDoC perspective. Dev. Psychopathol. 33:1634–47
     [Google Scholar]
143. Vassos E, Pedersen CB, Murray RM, Collier DA, Lewis CM. 2012. Meta-analysis of the association of urbanicity with schizophrenia. Schizophr. Bull. 38:1118–23
     [Google Scholar]
144. Walker E, Bollini AM. 2002. Pubertal neurodevelopment and the emergence of psychotic symptoms. Schizophr. Res. 54:17–23
     [Google Scholar]
145. Walker E, Mittal V, Tessner K. 2008. Stress and the hypothalamic pituitary adrenal axis in the developmental course of schizophrenia. Annu. Rev. Clin. Psychol. 4:189–216
     [Google Scholar]
146. Werner S, Malaspina D, Rabinowitz J. 2007. Socioeconomic status at birth is associated with risk of schizophrenia: population-based multilevel study. Schizophr. Bull. 33:1373–78
     [Google Scholar]
147. Whittle S, Barendse M, Pozzi E, Vijayakumar N, Simmons JG. 2020. Pubertal hormones predict sex-specific trajectories of pituitary gland volume during the transition from childhood to adolescence. NeuroImage 204:116256
     [Google Scholar]
148. Whittle S, Simmons JG, Byrne ML, Strikwerda-Brown C, Kerestes R et al. 2015. Associations between early adrenarche, affective brain function and mental health in children. Soc. Cogn. Affect. Neurosci. 10:1282–90
     [Google Scholar]
149. Wicks S, Hjern A, Gunnell D, Lewis G, Dalman C. 2005. Social adversity in childhood and the risk of developing psychosis: a national cohort study. Am. J. Psychiatry 162:1652–57
     [Google Scholar]
150. Wigman J, van Winkel R, Raaijmakers QA, Ormel J, Verhulst FC et al. 2011. Evidence for a persistent, environment-dependent and deteriorating subtype of subclinical psychotic experiences: a 6-year longitudinal general population study. Psychol. Med. 41:2317–29
     [Google Scholar]
151. Zhu X, Grace AA. 2021. Prepubertal environmental enrichment prevents dopamine dysregulation and hippocampal hyperactivity in MAM schizophrenia model rats. Biol. Psychiatry 89:298–307
     [Google Scholar]