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Abstract

Aggressive leukemias arise in both children and adults as a result of rearrangements to the mixed-lineage leukemia gene () located on chromosome 11q23. encodes a large histone methyltransferase that directly binds DNA and positively regulates gene transcription, including homeobox () genes. is involved in chromosomal translocations, partial tandem duplications, and amplifications, all of which result in hematopoietic malignancies due to sustained expression and stalled differentiation. lesions are associated with both acute myeloid leukemia and acute lymphoid leukemia and are usually associated with a relatively poor prognosis despite improved treatment options such as allogeneic hematopoietic stem cell transplantation, which underscores the need for new treatment regimens. Recent advances have begun to reveal the molecular mechanisms that drive MLL-associated leukemias, which, in turn, have provided opportunities for therapeutic development. Here, we discuss the etiology of MLL leukemias and potential directions for future therapy.

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/content/journals/10.1146/annurev-pathol-011811-132434
2012-02-28
2024-06-13
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  • Article Type: Review Article
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