1932

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that typically inhibit the translation and stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such as inflammation, cell-cycle regulation, stress response, differentiation, apoptosis, and migration. Thus, miRNAs have been implicated in the regulation of virtually all signaling circuits within a cell, and their dysregulation has been shown to play an essential role in the development and progression of cancer. Here, after a brief description of miRNA genomics, biogenesis, and function, we discuss the effects of miRNA dysregulation in the cellular pathways that lead to the progressive conversion of normal cells into cancer cells and the potential to develop new molecular miRNA-targeted therapies.

Keyword(s): cancermicroRNAsmiRsnoncoding RNAs

[Erratum, Closure]

An erratum has been published for this article:
Erratum: MicroRNAs in Cancer
Loading

Article metrics loading...

/content/journals/10.1146/annurev-pathol-012513-104715
2014-01-24
2024-06-18
Loading full text...

Full text loading...

/content/journals/10.1146/annurev-pathol-012513-104715
Loading
/content/journals/10.1146/annurev-pathol-012513-104715
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error