1932

Abstract

Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at risk for malignant transformation. However, accumulating evidence shows that senescent cells can have deleterious effects on the tissue microenvironment. The most significant of these effects is the acquisition of a senescence-associated secretory phenotype (SASP) that turns senescent fibroblasts into proinflammatory cells that have the ability to promote tumor progression.

Loading

Article metrics loading...

/content/journals/10.1146/annurev-pathol-121808-102144
2010-02-28
2024-10-06
Loading full text...

Full text loading...

/content/journals/10.1146/annurev-pathol-121808-102144
Loading
/content/journals/10.1146/annurev-pathol-121808-102144
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error