1932

Abstract

Engulfment and destruction of invading microorganisms by phagocytosis are critical components of the innate immune response. In addition, phagocytosis is also required for the clearance of apoptotic bodies, an essential aspect of tissue homeostasis and remodeling. Here, we summarize the current knowledge of the cellular and molecular basis of phagosome formation and maturation. We discuss the manner in which phagocytosis is subverted by certain pathogens and consider congenital disorders that affect phagocyte function.

Loading

Article metrics loading...

/content/journals/10.1146/annurev-pathol-011811-132445
2012-02-28
2024-04-15
Loading full text...

Full text loading...

/content/journals/10.1146/annurev-pathol-011811-132445
Loading
/content/journals/10.1146/annurev-pathol-011811-132445
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error