1932

Abstract

These words reflect my recollections of major transition points in my life and career: as I first became dedicated to becoming a physician, being introduced to the field of pathology and research, and then transitioning to a somewhat different career focus by becoming the first director of the National Institutes of Health Office of Research on Women's Health. Many of the experiences that I gained during my years in pathology served me well as I made efforts to establish women's health research and sex and gender based studies as scientific endeavors. Participating in research and teaching as an academic pathologist, setting funding priorities, and supporting and encouraging research careers through governmental office programs have been the essence of my more than 50 years as a pathologist and physician.

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2018-01-24
2024-12-04
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Literature Cited

  1. Barnes BA, Schad PB, Pinn VW. 1.  1966. Modification of the graft versus host reaction in F1 mice treated with 6-mercaptopurine. Transplantation 4:2154–58 [Google Scholar]
  2. Cope O. 2.  1997. The Breast: Its Problems, Benign and Malignant: And How to Deal with Them Boston: Houghton Mifflin [Google Scholar]
  3. Louis DN, Young RH. 3. , eds. 2011. Keen Minds to Explore the Dark Continents of Disease: A History of the Pathology Services at the Massachusetts General Hospital Boston: Mass. Gen. Hosp. [Google Scholar]
  4. Acosta JM, Nardi GL, Reeves G, Pinn VW, Buceta JC, Soloaga JC. 4.  1973. Histopathologic changes in the allografted canine pancreas. Arch. Surg. 106:844–47 [Google Scholar]
  5. Gupta PK, Pinn VW, Taft PD. 5.  1968. Cervical dysplasia associated with azathioprine (Imuran) therapy. Acta Cytol 13:7373–76 [Google Scholar]
  6. Jeannet M, Pinn VW, Flax MH, Winn HJ, Russell PS. 6.  1970. Humoral antibodies in renal allotransplantation in man. N. Engl. J. Med. 282:3111–17 [Google Scholar]
  7. Lyons H, Pinn VW, Cortell S, Cohen JJ, Harrington JT. 7.  1973. Allergic interstitial nephritis causing reversible renal failure in four patients with idiopathic nephrotic syndrome. N. Engl. J. Med. 288:3124–28 [Google Scholar]
  8. McCauley RGK, Safaii H, Crowley CA, Pinn VW. 8.  1979. Extra-renal Wilms' tumor. Am. J. Dis. Child 133:1174–77 [Google Scholar]
  9. Cosyns KP, Pirson Y, Squifflet JP, Alexandre GPJ, van Ypersele de Strihou C. 9.  et al. 1982. De novo membranous nephropathy in human renal allografts: report of nine cases. Kidney Int 22:177–83 [Google Scholar]
  10. Goldberg MJ, Kaplan MM, Anderson CL, Mitamura T, Matloff DS. 10.  et al. 1982. Evidence against an immune complex pathogenesis of primary biliary cirrhosis. Gastroenterology 83:3677–83 [Google Scholar]
  11. Chad D, Pariser K, Bradley WG, Adelman LS, Pinn VW. 11.  1982. The pathogenesis of cryoglobulinemic neuropathy. Neurology 32:725–30 [Google Scholar]
  12. Coggins CH. 12. , Collab. Study Adult Idiopathic Nephrotic Syndr. 1979. A controlled study of short-term prednisone treatment in adults with membranous nephropathy. Nephron 24:10 [Google Scholar]
  13. Abrass CK, Hall CL, Border WA, Brown CA, Glassock RJ. 13.  et al.(Collab. Study Adult Idiopathic Nephrotic Syndr.). 1980. Circulating immune complexes in adults with idiopathic nephrotic syndrome. Kidney Int 17:545–53 [Google Scholar]
  14. 14. Collab. Study Adult Idiopathic Nephrotic Syndr. 1979. A controlled study of short-term prednisone treatment in adults with membranous nephropathy. N. Engl. J. Med. 301:241301–6 [Google Scholar]
  15. Coggins CH. 15.  1986. Adult minimal change nephropathy: experience of the collaborative study of glomerular disease. Trans. Am. Clin. Climatol. Assoc. 97:18–26 [Google Scholar]
  16. 16. Spec. Collections Res. Cent. 2015. Guide to the Nancy E. Warner Papers 1930–1956. Univ. Chicago Library https://www.lib.uchicago.edu/e/scrc/findingaids/view.php?eadid=ICU.SPCL.WARNERN [Google Scholar]
  17. 17. Assoc. Am. Med. Coll. 2014. The state of women in academic medicine: the pipeline and pathways to leadership, 2013–2014 Rep., Assoc. Am. Med. Coll. Washington, DC: https://members.aamc.org/eweb/upload/The%20State%20of%20Women%20in%20Academic%20Medicine%202013-2014%20FINAL.pdf [Google Scholar]
  18. Pinn-Wiggins VW. 18. Collab. Study Adult Glomerular Dis. 1987. Nephrotic syndrome in blacks: histopathologic perspectives. Transplant. Proc. 19:249–55 [Google Scholar]
  19. Baker RB, Washington HA, Olakanmi O, Savitt TL, Jacobs EA. 19.  et al. 2008. African American physicians and organized medicine, 1846–1968: origins of a racial divide. JAMA 300:3306–13 [Google Scholar]
  20. Mastroianni AC, Faden R, Federman D. 20. , eds. 1994. Women and Health Research: Ethical and Legal Issues Including Women in Clinical Studies 1 Washington, DC: Natl. Acad. Press [Google Scholar]
  21. Legato MJ. 21.  2000. Is there a role for gender-specific medicine in today's health care system?. J. Gend. Specif. Med. 3:1215–21 [Google Scholar]
  22. Wenger NK. 22.  2004. You've come a long way, baby: cardiovascular health and disease in women: problems and prospects. Circulation 109:558–60 [Google Scholar]
  23. Grady D, Chaput L, Kristof M. 23.  2003. Diagnosis and Treatment of Coronary Heart Disease in Women: Systemic Reviews of Evidence on Selected Topics Publication No. 03-EO37 Rockville, MD: Agency Healthc. Res. Qual. [Google Scholar]
  24. 24. Mult. Risk Factor Interv. Trial (MRFIT). 1976. A national study of primary prevention of coronary heart disease. JAMA 235:8825–27 [Google Scholar]
  25. Neaton JD, Grimm RH Jr., Cutler JA. 25.  1987. Recruitment of participants for the multiple task factor intervention trial (MRFIT). Control. Clin. Trials 8:Suppl. 441S–53S [Google Scholar]
  26. 26. Physicians Health Study. 1988. The physicians' health study: aspirin for the primary prevention of myocardial infarction. N. Engl. J. Med. 318:924–26 [Google Scholar]
  27. Ridker PM, Cook NR, Lee IM, Gordon D, Gaziano JM,. 27.  et al. 2005. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N. Engl. J. Med. 352:293–304 [Google Scholar]
  28. 28. US Public Health Serv. 1985. Women's health: report of the Public Health Service Task Force on Women's Health Issues. Public Health Rep 1:76–106 [Google Scholar]
  29. Nadal MV. 29.  1990. National Institutes of Health: problems in implementing policy on women in study populations Rep. US Gen. Acount. Off Washington, DC: http://www.gao.gov/products/T-HRD-90-50 [Google Scholar]
  30. 30. US Dep. Health Hum. Serv. Public Health Serv. 1990. Press release: Establishment of the Office of Research on Women's Health News Release, Sept. 10, Natl. Inst. Health Bethesda, MD: [Google Scholar]
  31. Pinn VW, Chunko MT. 31.  1999. The NIH Office of Research on Women's Health and its DHHS partners: meeting challenges in women's health. J. Am. Med. Women's. Assoc. 54:115–19 [Google Scholar]
  32. Pinn VW. 32.  1994. The role of the NIH's Office of Research on Women's Health. Acad. Med. 69:9698–702 [Google Scholar]
  33. 33. US Dep. Health Hum. Serv. 1994. NIH guidelines on the inclusion of women and minorities as subjects in clinical research. 59 Fed. Reg. 11146-11151) (March 9).
  34. Kelty M, Bates A, Pinn VW. 34.  2012. National Institutes of Health policy on the inclusion of women and minorities as subjects in clinical research. Principles and Practice of Clinical Research JI Gallin, FP Ognibene 147–59 London: Elsevier. , 3rd ed.. [Google Scholar]
  35. Pinn VW. 35.  2011. From exclusion to inclusion—participation in biomedical research and the legacy of the public health syphilis study at Tuskegee. The Search for the Legacy of the USPHS Study at Tuskegee RV Katz, RC Warren 1–18 Lanham, MD: Lexington Books [Google Scholar]
  36. 36. Inst. Med. 2001. Exploring the Biological Contributions to Human Health: Does Sex Matter? Washington, DC: Natl. Acad. Press [Google Scholar]
  37. Clayton JA, Collins FS. 37.  2014. NIH to balance sex in cell and animal studies. Nature 509:7500282–83 [Google Scholar]
  38. 38. Inst. Med. 2012. Sex-Specific Reporting of Scientific Research: A Workshop Summary Washington, DC: Natl. Acad. Press [Google Scholar]
  39. Wood S, Blehar M, Mauery DR. 39.  2011. Policy implications of a new National Institutes of Health agenda for women's health research, 2010–2020. Women's Health Issues 21:299–103 [Google Scholar]
  40. 40. Off. Res. Women's Health, Natl. Inst. Health. 1992. Report of the National Institutes of Health: Opportunities for Research on Women's Health 1 2 Bethesda, MD: Natl. Inst. Health [Google Scholar]
  41. 41. Off. Res. Women's Health, Natl. Inst. Health. 1999. Agenda for Research on Women's Health for the 21st Century: A Report of the Task Force on the NIH Women's Health Research Agenda for the 21st Century Bethesda, MD: Natl. Inst. Health [Google Scholar]
  42. 42. Natl. Inst. Health (NIH). 2010. Highlights of NIH Women's Health and Sex Differences Research, 1990–2010 Bethesda, MD: Nat. Inst. Health. [Google Scholar]
  43. Rossouw JE, Finnegan LP, Harlan WR, Pinn VW, Clifford C, McGowan JA. 43.  1995. The evolution of the women's health initiative: perspectives from the NIH. J. Am. Med. Women's Assoc. 50:250–55 [Google Scholar]
  44. 44. Natl. Inst. Health (NIH). 2002. NHLBI stops trial of estrogen plus progestin due to increased breast cancer risk, lack of overall benefit News Release, Jul. 9 Natl. Inst. Health Bethesda MD: https://www.nhlbi.nih.gov/news/press-releases/2002/nhlbi-stops-trial-of-estrogen-plus-progestin-due-to-increased-breast-cancer-risk-lack-of-overall-benefit [Google Scholar]
  45. 45. Writ. Group Women's Health Initiat. Investig. 2002. Risks and benefits of estrogen plus progestin in healthy postmenopausal women principal results from the Women's Health Initiative randomized controlled trial. JAMA 288:3321–33 [Google Scholar]
  46. 46. Women's Health Initiat. Steer. Comm. 2004. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA 291:141701–12 [Google Scholar]
  47. Pinn VW. 47.  2005. Research on women's health: progress and opportunities. JAMA 294:111407–10 [Google Scholar]
  48. Pinn VW, Clayton JA, Begg L, Sass SE. 48.  2010. Public partnerships for a vision for women health research in 2020. J. Women's Health 19:91603–7 [Google Scholar]
  49. Pinn VW, Kravitz JY. 49.  2011. Expanding the evidence base for women's health across the lifespan. J. Dent. Educ. 75:3S11–19 [Google Scholar]
  50. 50. Off. Res. Women's Health. 2010. Moving into the Future with New Dimensions and Strategies: A Vision for 2020 for Women's Health Research Bethesda, MD: Natl. Inst. Health http://orwh.od.nih.gov/research/strategicplan/ORWH_StrategicPlan2020_Vol1.pdf [Google Scholar]
  51. Pinn VW. 51.  2005. Interdisciplinary research on women's health and sex/gender factors. Gend. Med. 2:3121–23 [Google Scholar]
  52. Pinn VW, Blehar MC. 52.  2011. Interdisciplinary women's health research and career development programs. Changing Landscape of Academic Medicine in Women's Healthcare WF Rayburn, J Schulkin 53–75 New York: Springer [Google Scholar]
  53. 53. Natl. Inst. Health (NIH). 1999. Building interdisciplinary research careers in women's health, RFA-OD-99-088 Natl. Inst. Health Bethesda, MD: http://grants2.nih.gov/grants/guide/rfa-files/RFA-OD-99-008.html [Google Scholar]
  54. 54. Natl. Inst. Health (NIH). 2001. Specialized Centers of Interdisciplinary Research on sex and gender factors affecting women's health (P50) RFA-OD-02-002 Natl. Inst. Health Bethesda, MD: http://grants.nih.gov/grants/guide/rfa-files/RFA-OD-02-002.html [Google Scholar]
  55. Hultgren S, Elam J. 55.  2008. Infectious disease and women's health. Nat. Rev. Microbiol. 6:4254 [Google Scholar]
  56. Plank-Bazinet JL, Whittington KB, Cassidy SKB, Filart R, Cornelison T. 56.  et al. 2016. Programmatic efforts at the National Institutes of Health to promote and support the careers of women in biomedical science. Acad. Med. 91:1057–64 [Google Scholar]
  57. 57. Natl. Inst. Health (NIH). 1994. Women in biomedical careers: dynamics of change, strategies for the 21st century Rep. Natl. Bethesda MD: [Google Scholar]
  58. 58. Comm. Maximizing Potential Women Acad. Sci. Eng., Comm. Sci. Eng. Public Policy, Inst. Med., Policy Glob. Aff., Natl. Acad. Sci., Natl. Acad. Eng. 2007. Beyond Bias and Barriers: Fulfilling the Potential of Women in Academic Science and Engineering Washington, DC: Natl. Acad. Press [Google Scholar]
  59. Pinn VW, Kravitz JY. 59.  2010. NIH efforts to promote and sustain the careers of women in science. Am. Soc. Cell Biol. Newsl. 33:213–14 [Google Scholar]
  60. Pohlhaus JR, Jiang H, Wagner R, Schaffer W, Pinn VW. 60.  2011. Sex differences in application, success, and funding rates for NIH extramural programs. Acad. Med. 86:6759–67 [Google Scholar]
  61. 61. Natl. Inst. Health (NIH). 2011. NIH family-friendly initiatives. Natl. Inst. Health, Bethesda, MD. https://grants.nih.gov/grants/family_friendly.htm
  62. 62. Natl. Inst. Health Intramural Res. Program. n.d. NIH work/life resources. Natl. Inst. Health, Bethesda, MD. https://irp.nih.gov/research-training/nih-work-life-resources
  63. 63. Natl. Inst. Health (NIH). 2011. Modification of the biographical sketch in NIH grant application forms (PHS 398, PHS 2590, and the SF 424 R&R) to permit a description of factors that may have reduced productivity News Release, Feb. 16 Natl. Inst. Health Bethesda, MD: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-11-045.html [Google Scholar]
  64. 64. Natl. Inst. Health. 2012. Causal factors and interventions workshop Nov. 8–9 Natl. Inst. Health Bethesda, MD: http://orwh.od.nih.gov/career/pdf/Causal-Factor-Summary.pdf [Google Scholar]
  65. 65. Inst. Med., Comm. Women's Health Res. 2010. Women's health research: progress, pitfalls, and promise Washington, DC: Natl. Acad. Press [Google Scholar]
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