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Annual Review of Pathology: Mechanisms of Disease

Volume 18, 2023

Molecular Monitoring of Lymphomas

Abstract

Molecular monitoring of tumor-derived alterations has an established role in the surveillance of leukemias, and emerging nucleic acid sequencing technologies are likely to similarly transform the clinical management of lymphomas. Lymphomas are well suited for molecular surveillance due to relatively high cell-free DNA and circulating tumor DNA concentrations, high somatic mutational burden, and the existence of stereotyped variants enabling focused interrogation of recurrently altered regions. Here, we review the clinical scenarios and key technologies applicable for the molecular monitoring of lymphomas, summarizing current evidence in the literature regarding molecular subtyping and classification, evaluation of treatment response, the surveillance of active cellular therapies, and emerging clinical trial strategies.

Keyword(s): circulating tumor DNA, lymphoma, measurable residual disease, next generation sequencing, response assessment
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/content/journals/10.1146/annurev-pathol-050520-044652
2023-01-24
2024-05-13
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/content/journals/10.1146/annurev-pathol-050520-044652
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Molecular Monitoring of Lymphomas
Annual Review of Pathology: Mechanisms of Disease 18, 149 (2023); https://doi.org/10.1146/annurev-pathol-050520-044652
/content/journals/10.1146/annurev-pathol-050520-044652
/content/journals/10.1146/annurev-pathol-050520-044652
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