1932

Abstract

Many communities are located near multiple sources of pollution, including current and former industrial sites, major roadways, and agricultural operations. Populations in such locations are predominantly low-income, with a large percentage of minorities and non-English speakers. These communities face challenges that can affect the health of their residents, including limited access to health care, a shortage of grocery stores, poor housing quality, and a lack of parks and open spaces. Environmental exposures may interact with social stressors, thereby worsening health outcomes. Age, genetic characteristics, and preexisting health conditions increase the risk of adverse health effects from exposure to pollutants. There are existing approaches for characterizing cumulative exposures, cumulative risks, and cumulative health impacts. Although such approaches have merit, they also have significant constraints. New developments in exposure monitoring, mapping, toxicology, and epidemiology, especially when informed by community participation, have the potential to advance the science on cumulative impacts and to improve decision making.

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2016-03-18
2024-10-14
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Literature Cited

  1. Alexeeff G, Faust J, August LM, Milanes C, Randles K, Zeise L. 1.  2010. Cumulative Impacts: Building a Scientific Foundation Sacramento, CA: Off. Environ. Health Hazard Assess http://www.oehha.ca.gov/ej/pdf/CIReport123110.pdf [Google Scholar]
  2. Ball E. 2.  2011. Conference highlights toxicogenomics, bioinformatics and computational biology. Environ. Factor. Oct. http://www.niehs.nih.gov/news/newsletter/2011/october/science-conference/ [Google Scholar]
  3. Briggs D. 3.  2003. Environmental pollution and the global burden of disease. Br. Med. Bull. 68:1–24 [Google Scholar]
  4. Buckley B, Farraj A. 4.  2015. Conceptual model for assessing criteria air pollutants in a multipollutant context: a modified adverse outcome pathway approach. Toxicology 335:85–94 [Google Scholar]
  5. Bullard RD. 5.  1990. Dumping in Dixie: Race, Class, and Environmental Quality Boulder, CO: Westview [Google Scholar]
  6. 6. CalEPA (Calif. Environ. Prot. Agency) 2015. Greenhouse gas-reduction investment to benefit disadvantaged communities Updated Feb. 9, CalEPA, Sacramento, CA. http://www.calepa.ca.gov/EnvJustice/GHGInvest [Google Scholar]
  7. 7. Calif. Dep. Public Health, Dep. Toxic Subst. Control, Off. Environ. Health Hazard Assess 2015. Biomonitoring California's Results Database. Updated Sept. 22, Biomonitor. Calif., Sacramento. http://www.biomonitoring.ca.gov/results/explore [Google Scholar]
  8. 8. CDC (Cent. Dis. Control Prev.) 2012. Healthy places. Health impact assessment. What is the relationship of HIA to environmental impact assessment? Updated July 25, CDC, Atlanta. http://www.cdc.gov/healthyplaces/relationship.htm [Google Scholar]
  9. 9. CDC (Cent. Dis. Control Prev.), Dep. Health Hum. Serv 2009. Fourth National Report on Human Exposure to Environmental Chemicals Atlanta: CDC http://www.cdc.gov/exposurereport/pdf/fourthreport.pdf [Google Scholar]
  10. 10. CDHS (Calif. Dep. Health Serv.) 1985. Guidelines for Chemical Carcinogen Risk Assessments and Their Scientific Rationale Sacramento, CA: CDHS, Health Welf. Agency [Google Scholar]
  11. Chen E, Schreier HM, Strunk RC, Brauer M. 11.  2008. Chronic traffic-related air pollution and stress interact to predict biologic and clinical outcomes in asthma. Environ. Health Perspect. 116:970–75 [Google Scholar]
  12. Churchill GA, Gatti DM, Munger SC, Svenson KL. 12.  2012. The Diversity Outbred mouse population. Mamm. Genome 23:713–18 [Google Scholar]
  13. Clougherty JE, Levy JI, Kubzansky LD, Ryan PB, Suglia SF. 13.  et al. 2007. Synergistic effects of traffic-related air pollution and exposure to violence on urban asthma etiology. Environ. Health Perspect. 115:1140–46 [Google Scholar]
  14. Cole BL, Fielding JE. 14.  2007. Health impact assessment: a tool to help policy makers understand health beyond health care. Annu. Rev. Public Health 28:393–412 [Google Scholar]
  15. Cox S, Niskar AS, Narayan KM, Marcus M. 15.  2007. Prevalence of self-reported diabetes and exposure to organochlorine pesticides among Mexican Americans: Hispanic Health and Nutrition Examination Survey, 1982–1984. Environ. Health Perspect. 115:1747–52 [Google Scholar]
  16. Crimmins EM, Johnston M, Hayward M, Seeman T. 16.  2003. Age differences in allostatic load: an index of physiological dysregulation. Exp. Gerontol. 38:731–34 [Google Scholar]
  17. Danese A, McEwen BS. 17.  2012. Adverse childhood experiences, allostasis, allostatic load, and age-related disease. Physiol. Behav. 106:29–39 [Google Scholar]
  18. 18. Eur. Cent. Health Policy 1999. Health Impact Assessment. Main Concepts and Suggested Approach. Gothenburg Consensus Paper. December, 1999. Brussels: WHO Reg. Off. Eur. [Google Scholar]
  19. 19. Exec. Order 12898, 59 F.R. 7629. (Feb. 16 1994.
  20. Finkelstein MM, Jerrett M, DeLuca P, Finkelstein N, Verma DK. 20.  et al. 2003. Relation between income, air pollution and mortality: a cohort study. Can. Med. Assoc. J. 169:397–402 [Google Scholar]
  21. French JE, Gatti DM, Morgan DL, Kissling GE, Shockley KR. 21.  et al. 2015. Diversity outbred mice identify population-based exposure thresholds and genetic factors that influence benzene-induced genotoxicity. Environ. Health Perspect. 123:237–45 [Google Scholar]
  22. Furlong CE, Holland N, Richter RJ, Bradman A, Ho A, Eskenazi B. 22.  2006. PON1 status of farmworker mothers and children as a predictor of organophosphate sensitivity. Pharmacogenet. Genom. 16:183–90 [Google Scholar]
  23. Gao T, Wang XC, Chen R, Ngo HH, Guo W. 23.  2015. Disability adjusted life year (DALY): a useful tool for quantitative assessment of environmental pollution. Sci. Total Environ. 511:268–87 [Google Scholar]
  24. 24. GBD 2013. Mortal. Causes Death Collab. 2015. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 385:117–71 [Google Scholar]
  25. Geronimus AT, Hicken M, Keene D, Bound J. 25.  2006. “Weathering” and age patterns of allostatic load scores among blacks and whites in the United States. Am. J. Public Health 96:826–33 [Google Scholar]
  26. Gilbert LK, Breiding MJ, Merrick MT, Thompson WW, Ford DC. 26.  et al. 2015. Childhood adversity and adult chronic disease: an update from ten states and the District of Columbia, 2010. Am. J. Prev. Med. 48:345–49 [Google Scholar]
  27. Glass TA, Bandeen-Roche K, McAtee M, Bolla K, Todd AC, Schwartz BS. 27.  2009. Neighborhood psychosocial hazards and the association of cumulative lead dose with cognitive function in older adults. Am. J. Epidemiol. 169:683–92 [Google Scholar]
  28. Hightower JM, O'Hare A, Hernandez GT. 28.  2006. Blood mercury reporting in NHANES: identifying Asian, Pacific Islander, Native American, and multiracial groups. Environ. Health Perspect. 114:173–75 [Google Scholar]
  29. Hynes HP, Lopez R. 29.  2007. Cumulative risk and a call for action in environmental justice communities. J. Health Disparities Res. Pract. 1:27–57 [Google Scholar]
  30. 30. Inst. Health Metrics Eval 2015. Global Burden of Disease. GBD history. Inst. Health Metrics Eval., Seattle, Wash. http://www.healthdata.org/gbd/about/history [Google Scholar]
  31. 31. IOM (Inst. Med.), Comm. Environ. Justice 1999. Toward Environmental Justice: Research, Education, and Health Policy Needs Washington, DC: Natl. Acad. Press [Google Scholar]
  32. Juster RP, McEwen BS, Lupien SJ. 32.  2010. Allostatic load biomarkers of chronic stress and impact on health and cognition. Neurosci. Biobehav. Rev. 35:2–16 [Google Scholar]
  33. Lister R, Pelizzola M, Dowen RH, Hawkins RD, Hon G. 33.  et al. 2009. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 462:315–22 [Google Scholar]
  34. Lynch JW, Kaplan GA, Shema SJ. 34.  1997. Cumulative impact of sustained economic hardship on physical, cognitive, psychological, and social functioning. N. Engl. J. Med. 337:1889–95 [Google Scholar]
  35. McEwen B, Seeman T. 35.  with Allostatic Load Work. Group 2009. Allostatic load and allostasis. Allostatic Notebook. Last revis. Aug. San Francisco: MacArthur Found http://www.macses.ucsf.edu/research/allostatic/allostatic.php [Google Scholar]
  36. McEwen BS. 36.  1998. Protective and damaging effects of stress mediators. N. Engl. J. Med. 338:171–79 [Google Scholar]
  37. Menzie CA, MacDonell MM, Mumtaz M. 37.  2007. A phased approach for assessing combined effects from multiple stressors. Environ. Health Perspect. 115:807–16 [Google Scholar]
  38. Morello-Frosch R, Brody JG, Brown P, Altman RG, Rudel RA, Perez C. 38.  2009. Toxic ignorance and right-to-know in biomonitoring results communication: a survey of scientists and study participants. Environ. Health 8:6 [Google Scholar]
  39. Morello-Frosch R, Jesdale BM, Sadd JL, Pastor M. 39.  2010. Ambient air pollution exposure and full-term birth weight in California. Environ. Health 9:44 [Google Scholar]
  40. Morello-Frosch R, Zuk M, Jerrett M, Shamasunder B, Kyle AD. 40.  2011. Understanding the cumulative impacts of inequalities in environmental health: implications for policy. Health Aff. 30:879–87 [Google Scholar]
  41. Murray CJL, Lopez AD. 41.  1996. The Global Burden of Disease: A Comprehensive Assessment of Mortality and Disability from Diseases, Injuries, and Risk Factors in 1990 and Projected to 2020 Cambridge, MA: Harvard Sch. Public Health on behalf of the World Health Organ., World Bank [Google Scholar]
  42. 42. Natl. Res. Counc., Comm. Health Impact Assess., Board Environ. Stud. Toxicol 2011. Improving Health in the United States: The Role of Health Impact Assessment Washington, DC: Natl. Acad. Press [Google Scholar]
  43. 43. Natl. Res. Counc., Comm. Improv. Risk Anal. Approaches Used by the U.S EPA, Board Environ. Stud. Toxicol., Div. Earth Life Stud 2009. Science and Decisions: Advancing Risk Assessment Washington, DC: Natl. Acad. Press [Google Scholar]
  44. 44. NEJAC (Natl. Environ. Justice Advis. Counc.) 2004. Ensuring Risk Reduction in Communities with Multiple Stressors: Environmental Justice and Cumulative Risks/Impacts Washington, DC: NEJAC [Google Scholar]
  45. O'Connor A, Quizon PM, Albright JE, Lin FT, Bennett BJ. 45.  2014. Responsiveness of cardiometabolic-related microbiota to diet is influenced by host genetics. Mamm. Genome 25:583–99 [Google Scholar]
  46. O'Neill MS, Jerrett M, Kawachi I, Levy JI, Cohen AJ. 46.  et al. 2003. Health, wealth, and air pollution: advancing theory and methods. Environ. Health Perspect. 111:1861–70 [Google Scholar]
  47. 47. OEHHA (Off. Environ. Health Hazard Assess.) 2014. California Communities Environmental Health, Version 2.0 (CalEnviroScreen 2.0) screening tool. Updated Oct., OEHHA, Calif. Environ. Prot. Agency, Sacramento. http://www.oehha.ca.gov/ej/ces2.html [Google Scholar]
  48. Olden K, Lin YS, Gruber D, Sonawane B. 48.  2014. Epigenome: biosensor of cumulative exposure to chemical and nonchemical stressors related to environmental justice. Am. J. Public Health 104:1816–21 [Google Scholar]
  49. Peters JL, Weisskopf MG, Spiro A 3rd, Schwartz J, Sparrow D. 49.  et al. 2010. Interaction of stress, lead burden, and age on cognition in older men: The VA Normative Aging Study. Environ. Health Perspect. 118:505–10 [Google Scholar]
  50. Ponce NA, Hoggatt KJ, Wilhelm M, Ritz B. 50.  2005. Preterm birth: the interaction of traffic-related air pollution with economic hardship in Los Angeles neighborhoods. Am. J. Epidemiol. 162:140–48 [Google Scholar]
  51. Ragas AM, Oldenkamp R, Preeker NL, Wernicke J, Schlink U. 51.  2011. Cumulative risk assessment of chemical exposures in urban environments. Environ. Int. 37:872–81 [Google Scholar]
  52. Romani M, Pistillo MP, Banelli B. 52.  2015. Environmental epigenetics: crossroad between public health, lifestyle, and cancer prevention. Biomed. Res. Int. 2015:587983 [Google Scholar]
  53. Sadd J, Morello-Frosch R, Pastor M, Matsuoka M, Prichard M, Carter V. 53.  2013. The truth, the whole truth, and nothing but the ground-truth: methods to advance environmental justice and researcher-community partnerships. Health Educ. Behav. 41:281–90 [Google Scholar]
  54. Sadd JL, Pastor M, Morello-Frosch R, Scoggins J, Jesdale B. 54.  2011. Playing it safe: assessing cumulative impact and social vulnerability through an environmental justice screening method in the South Coast Air Basin, California. Int. J. Environ. Res. Public Health 8:1441–59 [Google Scholar]
  55. Sandel M, Wright RJ. 55.  2006. When home is where the stress is: expanding the dimensions of housing that influence asthma morbidity. Arch. Dis. Child 91:942–48 [Google Scholar]
  56. Seeman T, Merkin SS, Crimmins E, Koretz B, Charette S, Karlamangla A. 56.  2008. Education, income and ethnic differences in cumulative biological risk profiles in a national sample of US adults: NHANES III (1988–1994). Soc. Sci. Med. 66:72–87 [Google Scholar]
  57. Seeman TE, Singer BH, Rowe JW, Horwitz RI, McEwen BS. 57.  1997. Price of adaptation—allostatic load and its health consequences. MacArthur Studies of Successful Aging. Arch. Intern. Med. 157:2259–68 [Google Scholar]
  58. Sexton K. 58.  2012. Cumulative risk assessment: an overview of methodological approaches for evaluating combined health effects from exposure to multiple environmental stressors. Int. J. Environ. Res. Public Health 9:370–90 [Google Scholar]
  59. Sexton K, Kleffman DE, Callahan MA. 59.  1995. An introduction to the National Human Exposure Assessment Survey (NHEXAS) and related phase I field studies. J. Expo. Anal. Environ. Epidemiol. 5:229–32 [Google Scholar]
  60. Shankardass K, McConnell R, Jerrett M, Milam J, Richardson J, Berhane K. 60.  2009. Parental stress increases the effect of traffic-related air pollution on childhood asthma incidence. PNAS 106:12406–11 [Google Scholar]
  61. South EC, Kondo MC, Cheney RA, Branas CC. 61.  2015. Neighborhood blight, stress, and health: a walking trial of urban greening and ambulatory heart rate. Am. J. Public Health 105:909–13 [Google Scholar]
  62. Threadgill DW, Miller DR, Churchill GA, de Villena FP. 62.  2011. The collaborative cross: a recombinant inbred mouse population for the systems genetic era. ILAR J. 52:24–31 [Google Scholar]
  63. 63. US EPA (Environ. Prot. Agency) 1998. Guidelines for Ecological Risk Assessment Washington, DC: US EPA http://www2.epa.gov/osa/guidelines-ecological-risk-assessment [Google Scholar]
  64. 64. US EPA (Environ. Prot. Agency) 2015. EJSCREEN: Environmental Justice Screening Tool Updated Sept. 16, US EPA, Washington, DC. http://www2.epa.gov/ejscreen [Google Scholar]
  65. 65. US EPA (Environ. Prot. Agency) 2015. ToxCastTM. Advancing the next generation of chemical safety evaluation. Updated Sept. 25, US EPA, Washington, DC. http://www.epa.gov/ncct/toxcast [Google Scholar]
  66. 66. US EPA (Environ. Prot. Agency), Off. Emerg. Remedial Response 1989. Risk Assessment Guidance for Superfund. Volume I. Human Evaluation Manual (Part A). Interim Final. EPA/540/1–89/002 Washington, DC: Off. Emerg. Remedial Response, US EPA (Environ. Prot. Agency) http://www2.epa.gov/sites/production/files/2015-09/documents/rags_a.pdf [Google Scholar]
  67. 67. US EPA (Environ. Prot. Agency), Off. Res. Dev 2003. Framework for Cumulative Risk Assessment. EPA/600/P-02/001F Washington, DC: US EPA http://www2.epa.gov/sites/production/files/2014-11/documents/frmwrk_cum_risk_assmnt.pdf [Google Scholar]
  68. Van den Berg M, Birnbaum L, Bosveld AT, Brunstrom B, Cook P. 68.  et al. 1998. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ. Health Perspect. 106:775–92 [Google Scholar]
  69. 69. Wallace LA, Off. Res. Dev., US EPA (Environ. Prot. Agency) 1987. The Total Exposure Assessment Methodology (TEAM) Study. EPA/600/6–87/002 Washington, DC: US EPA (Environ. Prot. Agency) http://nepis.epa.gov/Adobe/PDF/2000UC5T.pdf [Google Scholar]
  70. Wernham A. 70.  2007. Inupiat health and proposed Alaskan oil development: results of the first integrated health impact assessment/environmental impact statement for proposed oil development on Alaska's North Slope. EcoHealth 4:500–13 [Google Scholar]
  71. Wild CP. 71.  2012. The exposome: from concept to utility. Int. J. Epidemiol. 41:24–32 [Google Scholar]
  72. Woodruff TJ, Zota AR, Schwartz JM. 72.  2011. Environmental chemicals in pregnant women in the United States: NHANES 2003–2004. Environ. Health Perspect. 119:878–85 [Google Scholar]
  73. 73. World Bank 1993. World Development Report 1993: Investing in Health New York: Oxford Univ. Press [Google Scholar]
  74. Yoo HS, Bradford BU, Kosyk O, Shymonyak S, Uehara T. 74.  et al. 2015. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects. J. Toxicol. Environ. Health A 78:15–31 [Google Scholar]
  75. Zalli A, Carvalho LA, Lin J, Hamer M, Erusalimsky JD. 75.  et al. 2014. Shorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resources. PNAS 111:4519–24 [Google Scholar]
  76. Zeise L, Bois FY, Chiu WA, Hattis D, Rusyn I, Guyton KZ. 76.  2013. Addressing human variability in next-generation human health risk assessments of environmental chemicals. Environ. Health Perspect. 121:23–31 [Google Scholar]
  77. Zota AR, Shenassa ED, Morello-Frosch R. 77.  2013. Allostatic load amplifies the effect of blood lead levels on elevated blood pressure among middle-aged U.S. adults: a cross-sectional study. Environ. Health 12:64 [Google Scholar]
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