Since e-cigarettes appeared in the mid-2000s, some practitioners, researchers, and policy makers have embraced them as a safer alternative to conventional cigarettes and an effective way to stop smoking. While e-cigarettes deliver lower levels of carcinogens than do conventional cigarettes, they still expose users to high levels of ultrafine particles and other toxins that may substantially increase cardiovascular and noncancer lung disease risks, which account for more than half of all smoking-caused deaths, at rates similar to conventional cigarettes. Moreover, rather than stimulating smokers to switch from conventional cigarettes to less dangerous e-cigarettes or quitting altogether, e-cigarettes are reducing smoking cessation rates and expanding the nicotine market by attracting youth.


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Literature Cited

  1. Abrams DB. 1.  2014. Promise and peril of e-cigarettes: Can disruptive technology make cigarettes obsolete?. JAMA 311:135–36 [Google Scholar]
  2. Adkison SE, O'Connor RJ, Bansal-Travers M, Hyland A, Borland R. 2.  et al. 2013. Electronic nicotine delivery systems: International Tobacco Control Four-Country Survey. Am. J. Prev. Med. 44:207–15 [Google Scholar]
  3. 3. AIHA (Am. Ind. Hyg. Assoc.). 2014. White Paper: Electronic Cigarettes in the Indoor Environment Falls Church, VA: AIHA [Google Scholar]
  4. Al-Delaimy WK, Myers MG, Leas EC, Strong DR, Hofstetter CR. 4.  2015. E-cigarette use in the past and quitting behavior in the future: a population-based study. Am. J. Public Health 105:1213–19 [Google Scholar]
  5. Ambrose BK, Rostron BL, Johnson SE, Portnoy DB, Apelberg BJ. 5.  et al. 2014. Perceptions of the relative harm of cigarettes and e-cigarettes among U.S. youth. Am. J. Prev. Med. 47:S53–60 [Google Scholar]
  6. Andler R, Guignard R, Wilquin JL, Beck F, Richard JB, Nguyen-Thanh V. 6.  2016. Electronic cigarette use in France in 2014. Int. J. Public Health 61:159–65 [Google Scholar]
  7. 7. ANRF (Am. Nonsmok. Rights Found.). 2017. States and municipalities with laws regulating use of electronic cigarettes Updated July 3. ANRF Berkeley, CA: [Google Scholar]
  8. Apollonio D, Glantz S. 8.  2017. Tobacco industry research on nicotine replacement therapy: “If anyone is going to take away our business it should be us. .” Am. J. Public Health 17:e1–7 [Google Scholar]
  9. Arrazola RA, Singh T, Corey CG, Husten CG, Neff LJ. 9.  et al. 2015. Tobacco use among middle and high school students—United States, 2011–2014. MMWR 64:381–85 [Google Scholar]
  10. 10. ASHRAE (Am. Soc. Heat. Refrig. Air Cond. Eng.). 2016. Standards 62.1. Ventilation for Acceptable Indoor Air Quality. Atlanta: ASHRAE [Google Scholar]
  11. 11. ASHRAE (Am. Soc. Heat. Refrig. Air Cond. Eng.). 2016. Standard 62.2. Ventilation and Acceptable Indoor Air Quality in Residential Buildings Atlanta: ASHRAE [Google Scholar]
  12. Ballbe M, Martinez-Sanchez JM, Sureda X, Fu M, Perez-Ortuno R. 12.  et al. 2014. Cigarettes vs. e-cigarettes: passive exposure at home measured by means of airborne marker and biomarkers. Environ. Res. 135:76–80 [Google Scholar]
  13. Barnoya J, Glantz SA. 13.  2005. Cardiovascular effects of secondhand smoke: nearly as large as smoking. Circulation 111:2684–98 [Google Scholar]
  14. Barrington-Trimis JL, Berhane K, Unger JB, Cruz TB, Huh J. 14.  et al. 2015. Psychosocial factors associated with adolescent electronic cigarette and cigarette use. Pediatrics 136:308–17 [Google Scholar]
  15. Barrington-Trimis JL, Urman R, Berhane K, Unger JB, Cruz TB. 15.  et al. 2016. E-cigarettes and future cigarette use. Pediatrics 138:1–8 [Google Scholar]
  16. Benowitz NL, Fraiman JB. 16.  2017. Cardiovascular effects of electronic cigarettes. Nat. Rev. Cardiol. 14:447–56 [Google Scholar]
  17. Bhatnagar A. 17.  2016. E-cigarettes and cardiovascular disease risk: evaluation of evidence, policy implications, and recommendations. Curr. Cardiovasc. Risk Rep. 10:24 [Google Scholar]
  18. Bhatnagar A. 18.  2017. Are electronic cigarette users at increased risk for cardiovascular disease?. JAMA Cardiol 2:237–38 [Google Scholar]
  19. Biener L, Hargraves JL. 19.  2015. A longitudinal study of electronic cigarette use among a population-based sample of adult smokers: association with smoking cessation and motivation to quit. Nicotine Tob. Res. 17:127–33 [Google Scholar]
  20. Bold KW, Kong G, Cavallo DA, Camenga DR, Krishnan-Sarin S. 20.  2016. Reasons for trying e-cigarettes and risk of continued use. Pediatrics 138:1–8 [Google Scholar]
  21. Borderud SP, Li YL, Burkhalter JE, Sheffer CE, Ostroff JS. 21.  2014. Electronic cigarette use among patients with cancer: characteristics of electronic cigarette users and their smoking cessation outcomes. Cancer 120:3527–35 [Google Scholar]
  22. Brown J, Beard E, Kotz D, Michie S, West R. 22.  2014. Real-world effectiveness of e-cigarettes when used to aid smoking cessation: a cross-sectional population study. Addiction 109:1531–40 [Google Scholar]
  23. Bullen C, Howe C, Laugesen M, McRobbie H, Parag V. 23.  et al. 2013. Electronic cigarettes for smoking cessation: a randomised controlled trial. Lancet 382:1629–37 [Google Scholar]
  24. Bunnell RE, Agaku IT, Arrazola R, Apelberg BJ, Caraballo RS. 24.  et al. 2015. Intentions to smoke cigarettes among never-smoking U.S. middle and high school electronic cigarette users, National Youth Tobacco Survey, 2011–2013. Nicotine Tob. Res. 17:228–35 [Google Scholar]
  25. Caponnetto P, Campagna D, Cibella F, Morjaria JB, Caruso M. 25.  et al. 2013. EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as tobacco cigarettes substitute: a prospective 12-month randomized control design study. PLOS ONE 8:e66317 [Google Scholar]
  26. Carnevale R, Sciarretta S, Violi F, Nocella C, Loffredo L. 26.  et al. 2016. Acute impact of tobacco versus electronic cigarette smoking on oxidative stress and vascular function. Chest 150:606–12 [Google Scholar]
  27. 27. CDC (Cent. Dis. Control Prev.). 2016. QuickStats: cigarette smoking status among current adult e-cigarette users, by age group—National Health Interview Survey, United States, 2015. MMWR 65:1177 [Google Scholar]
  28. Cho JH, Paik SY. 28.  2016. Association between electronic cigarette use and asthma among high school students in South Korea. PLOS ONE 11:e0151022 [Google Scholar]
  29. Choi K, Forster JL. 29.  2014. Authors' response. Am. J. Prev. Med. 46:e58–59 [Google Scholar]
  30. Christensen T, Welsh E, Faseru B. 30.  2014. Profile of e-cigarette use and its relationship with cigarette quit attempts and abstinence in Kansas adults. Prev. Med. 69:90–94 [Google Scholar]
  31. Chun L, Moazed F, Calfee C, Matthay M, Gotts J. 31.  2017. Pulmonary toxicity of e-cigarettes. Am. J. Physiol. Lung Cell Mol. Physiol. 313:L193–206 [Google Scholar]
  32. Combes RD, Balls M. 32.  2015. On the safety of e-cigarettes: “I can resist anything except temptation. .” Altern. Lab. Anim. 43:417–25 [Google Scholar]
  33. Cox E, Barry RA, Glantz S. 33.  2016. E-cigarette policymaking by local and state governments: 2009–2014. Milbank Q 94:520–96 [Google Scholar]
  34. Czogala J, Goniewicz ML, Fidelus B, Zielinska-Danch W, Travers MJ, Sobczak A. 34.  2014. Secondhand exposure to vapors from electronic cigarettes. Nicotine Tob. Res. 16:655–62 [Google Scholar]
  35. Dutra LM, Glantz SA. 35.  2014. Electronic cigarettes and conventional cigarette use among U.S. adolescents: a cross-sectional study. JAMA Pediatr 168:610–17 [Google Scholar]
  36. Dutra LM, Glantz SA. 36.  2014. High international electronic cigarette use among never smoker adolescents. J. Adolesc. Health 55:595–97 [Google Scholar]
  37. Dutra LM, Glantz SA. 37.  2017. E-cigarettes and national adolescent cigarette use: 2004–2014. Pediatrics 139:2pii:e20162450 [Google Scholar]
  38. Dutra LM, Grana R, Glantz SA. 38.  2016. Philip Morris research on precursors to the modern e-cigarette since 1990. Tob. Control. https://www.doi.org/10.1136/tobaccocontrol-2016-053406 [Crossref] [Google Scholar]
  39. 39. Editors. 2015. E-cigarettes: Public Health England's evidence-based confusion. Lancet 386:829 [Google Scholar]
  40. El Dib R, Suzumura EA, Akl EA, Gomaa H, Agarwal A. 40.  et al. 2017. Electronic nicotine delivery systems and/or electronic non-nicotine delivery systems for tobacco smoking cessation or reduction: a systematic review and meta-analysis. BMJ Open 7:e012680 [Google Scholar]
  41. England LJ, Bunnell RE, Pechacek TF, Tong VT, McAfee TA. 41.  2015. Nicotine and the developing human: a neglected element in the electronic cigarette debate. Am. J. Prev. Med. 49:286–93 [Google Scholar]
  42. Fallin A, Grana R, Glantz SA. 42.  2014. ‘To quarterback behind the scenes, third-party efforts’: the tobacco industry and the Tea Party. Tob. Control 23:322–31 [Google Scholar]
  43. Fichtenberg CM, Glantz SA. 43.  2002. Effect of smoke-free workplaces on smoking behaviour: systematic review. BMJ 325:188 [Google Scholar]
  44. Fuller T, Acharya A, Bhaskar G, Yu M, Little S, Tarin T. 44.  MP88-14 evaluation of e-cigarettes users urine for known bladder carcinogens. J. Urol 197:e1179 [Google Scholar]
  45. Fuoco FC, Buonanno G, Stabile L, Vigo P. 45.  2014. Influential parameters on particle concentration and size distribution in the mainstream of e-cigarettes. Environ. Pollut. 184:523–29 [Google Scholar]
  46. Geiss O, Bianchi I, Barahona F, Barrero-Moreno J. 46.  2015. Characterisation of mainstream and passive vapours emitted by selected electronic cigarettes. Int. J. Hyg. Environ. Health 218:169–80 [Google Scholar]
  47. Glantz SA. 47.  2017. Need for examination of broader range of risks when predicting the effects of new tobacco products. Nicotine Tob. Res. 19:266–67 [Google Scholar]
  48. Gmel G, Baggio S, Mohler-Kuo M, Daeppen J-B, Studer J. 48.  2016. E-cigarette use in young Swiss men: Is vaping an effective way of reducing or quitting smoking?. Swiss Med. Wkly. 146:w14271 [Google Scholar]
  49. Goel R, Durand E, Trushin N, Prokopczyk B, Foulds J. 49.  et al. 2015. Highly reactive free radicals in electronic cigarette aerosols. Chem. Res. Toxicol. 28:1675–77 [Google Scholar]
  50. Goniewicz ML, Knysak J, Gawron M, Kosmider L, Sobczak A. 50.  et al. 2014. Levels of selected carcinogens and toxicants in vapour from electronic cigarettes. Tob. Control 23:133–39 [Google Scholar]
  51. Gornall J. 51.  2015. Public Health England's troubled trail. BMJ 351:h5826 [Google Scholar]
  52. Gorukanti A, Delucchi K, Ling P, Fisher-Travis R, Halpern-Felsher B. 52.  2017. Adolescents' attitudes towards e-cigarette ingredients, safety, addictive properties, social norms, and regulation. Prev. Med. 94:65–71 [Google Scholar]
  53. Grana R, Benowitz N, Glantz SA. 53.  2014. E-cigarettes: a scientific review. Circulation 129:1972–86 [Google Scholar]
  54. Grana RA, Popova L, Ling PM. 54.  2014. A longitudinal analysis of electronic cigarette use and smoking cessation. JAMA Intern. Med. 174:812–13 [Google Scholar]
  55. Hajek P, Corbin L, Ladmore D, Spearing E. 55.  2015. Adding e-cigarettes to specialist stop-smoking treatment: City of London pilot project. J. Addict. Res. Ther. 6:2 [Google Scholar]
  56. Halcox JP, Schenke WH, Zalos G, Mincemoyer R, Prasad A. 56.  et al. 2002. Prognostic value of coronary vascular endothelial dysfunction. Circulation 106:653–58 [Google Scholar]
  57. Harrington KF, Cheong J, Hendricks S, Kohler C, Bailey WC. 57.  2015. E-cigarette and traditional cigarette use among smokers during hospitalization and 6 months later. Cancer Epidemiol. Biomark. Prev. 24:762 [Google Scholar]
  58. Hartmann-Boyce J, McRobbie H, Bullen C, Begh R, Stead LF, Hajek P. 58.  2016. Electronic cigarettes for smoking cessation. Cochrane Database Syst. Rev. 9:CD010216 [Google Scholar]
  59. Heeschen C, Jang JJ, Weis M, Pathak A, Kaji S. 59.  et al. 2001. Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis. Nat. Med. 7:833–39 [Google Scholar]
  60. Hengstler JG, Bogdanffy MS, Bolt HM, Oesch F. 60.  2003. Challenging dogma: thresholds for genotoxic carcinogens? The case of vinyl acetate. Annu. Rev. Pharmacol. Toxicol. 43:485–520 [Google Scholar]
  61. Higham A, Rattray NJ, Dewhurst JA, Trivedi DK, Fowler SJ. 61.  et al. 2016. Electronic cigarette exposure triggers neutrophil inflammatory responses. Respir. Res. 17:56 [Google Scholar]
  62. Hirano T, Tabuchi T, Nakahara R, Kunugita N, Mochizuki-Kobayashi Y. 62.  2017. Electronic cigarette use and smoking abstinence in Japan: a cross-sectional study of quitting methods. Int. J. Environ. Res. Public Health 14:202 [Google Scholar]
  63. Hitchman SC, Brose LS, Brown J, Robson D, McNeill A. 63.  2015. Associations between e-cigarette type, frequency of use, and quitting smoking: findings from a longitudinal online panel survey in Great Britain. Nicotine Tob. Res. 17:1187–94 [Google Scholar]
  64. Hom S, Chen L, Wang T, Ghebrehiwet B, Yin W, Rubenstein DA. 64.  2016. Platelet activation, adhesion, inflammation, and aggregation potential are altered in the presence of electronic cigarette extracts of variable nicotine concentrations. Platelets 27:694–702 [Google Scholar]
  65. Hornik RC, Gibson L, Lerman C. 65.  2016. Prediction of cigarette use from prior electronic and combustible cigarette use for a national sample of 13–25 year olds Abstr. POS5-30. Presented at Soc. Res. Nicotine Tob., March 2–4, Chicago. https://c.ymcdn.com/sites/www.srnt.org/resource/resmgr/Conferences/2016_Annual_Meeting/Program/SRNT_2016_Rapids_WEB2.pdf [Google Scholar]
  66. Human D. 66.  2010. Wise Nicotine Lowestoft, UK: Dennis Barber [Google Scholar]
  67. Hwang JH, Lyes M, Sladewski K, Enany S, McEachern E. 67.  et al. 2016. Electronic cigarette inhalation alters innate immunity and airway cytokines while increasing the virulence of colonizing bacteria. J. Mol. Med. 94:667–79 [Google Scholar]
  68. Johnston LD, O'Malley PM, Miech RA, Bachman JG, Schulenberg JE. 68.  2016. Monitoring the Future. National Survey Results on Drug Use, 1975–2015: 2015 Overview. Key Findings on Adolescent Drug Use. Ann Arbor: Inst. Soc. Res., Univ. Mich. http://www.monitoringthefuture.org/pubs/monographs/mtf-overview2015.pdf [Google Scholar]
  69. Kalkhoran S, Glantz SA. 69.  2015. Modeling the health effects of expanding e-cigarette sales in the United States and United Kingdom: a Monte Carlo analysis. JAMA Intern. Med. 175:1671–80 [Google Scholar]
  70. Kalkhoran S, Glantz SA. 70.  2016. E-cigarettes and smoking cessation in real-world and clinical settings: a systematic review and meta-analysis. Lancet Respir. Med. 4:116–28 [Google Scholar]
  71. Khoudigian S, Devji T, Lytvyn L, Campbell K, Hopkins R, O'Reilly D. 71.  2016. The efficacy and short-term effects of electronic cigarettes as a method for smoking cessation: a systematic review and a meta-analysis. Int. J. Public Health 61:257–67 [Google Scholar]
  72. Kong G, Morean ME, Cavallo DA, Camenga DR, Krishnan-Sarin S. 72.  2015. Reasons for electronic cigarette experimentation and discontinuation among adolescents and young adults. Nicotine Tob. Res. 17:847–54 [Google Scholar]
  73. Kosmider L, Sobczak A, Fik M, Knysak J, Zaciera M. 73.  et al. 2014. Carbonyl compounds in electronic cigarette vapors: effects of nicotine solvent and battery output voltage. Nicotine Tob. Res. 16:1319–26 [Google Scholar]
  74. Kostygina G, England L, Ling P. 74.  2016. New product marketing blurs the line between nicotine replacement therapy and smokeless tobacco products. Am. J. Public Health 106:1219–22 [Google Scholar]
  75. Kulik M, Lisha N, Glantz S. 75. 2018 Electronic cigarette use is associated with lower odds of having stopped smoking: a cross-sectional study of 28 European Union countries. Am. J. Prev. Med In press [Google Scholar]
  76. Laugesen M. 76.  2008. Safety Report on the Ruyan® E-Cigarette Cartridge and Inhaled Aerosol Christch., NZ: Health N. Z http://www.healthnz.co.nz/RuyanCartridgeReport30-Oct-08.pdf [Google Scholar]
  77. Lee S, Grana R, Glantz S. 77.  2014. Electronic cigarette use among Korean adolescents: a cross-sectional study of market penetration, dual use, and relationship to quit attempts and former smoking. J. Adolesc. Health 54:684–90 [Google Scholar]
  78. Lempert LK, Grana R, Glantz SA. 78.  2016. The importance of product definitions in US e-cigarette laws and regulations. Tob. Control 25:e44–51 [Google Scholar]
  79. Leventhal AM, Strong DR, Kirkpatrick MG, Unger JB, Sussman S. 79.  et al. 2015. Association of electronic cigarette use with initiation of combustible tobacco product smoking in early adolescence. JAMA 314:700–7 [Google Scholar]
  80. Levy DT, Borland R, Villanti AC, Niaura R, Yuan Z. 80.  et al. 2017. The application of a decision-theoretic model to estimate the public health impact of vaporized nicotine product initiation in the United States. Nicotine Tob. Res. 19:149–59 [Google Scholar]
  81. Manzoli L, Flacco ME, Ferrante M, La Vecchia C, Siliquini R. 81.  et al. 2017. Cohort study of electronic cigarette use: effectiveness and safety at 24 months. Tob. Control 26:284–92 [Google Scholar]
  82. Martin EM, Clapp PW, Rebuli ME, Pawlak EA, Glista-Baker E. 82.  et al. 2016. E-cigarette use results in suppression of immune and inflammatory-response genes in nasal epithelial cells similar to cigarette smoke. Am. J. Physiol. Lung Cell Mol. Physiol. 311:L135–44 [Google Scholar]
  83. McConnell R, Barrington-Trimis JL, Wang K, Urman R, Hong H. 83.  et al. 2017. Electronic cigarette use and respiratory symptoms in adolescents. Am. J. Respir. Crit. Care Med. 195:1043–49 [Google Scholar]
  84. McKee M, Capewell S. 84.  2015. Evidence about electronic cigarettes: a foundation built on rock or sand?. BMJ 351:h4863 [Google Scholar]
  85. McNeill A, Brose LS, Calder R, Hitchman SC, Hajek P, McRobbie H. 85.  2015. E-Cigarettes: An Evidence Update. A Report Commissioned by Public Health England. London: Public Health Engl https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/457102/Ecigarettes_an_evidence_update_A_report_commissioned_by_Public_Health_England_FINAL.pdf [Google Scholar]
  86. McQueen N, Partington EJ, Harrington KF, Rosenthal EL, Carroll WR, Schmalbach CE. 86.  2016. Smoking cessation and electronic cigarette use among head and neck cancer patients. Otolaryngol. Head Neck Surg. 154:73–79 [Google Scholar]
  87. McRobbie H, Bullen C, Hartmann-Boyce J, Hajek P. 87.  2014. Electronic cigarettes for smoking cessation and reduction. Cochrane Database Syst. Rev.12CD010216 [Google Scholar]
  88. Miech RA, O'Malley PM, Johnston LD, Patrick ME. 88.  2016. E-cigarettes and the drug use patterns of adolescents. Nicotine Tob. Res. 18:654–59 [Google Scholar]
  89. Mincer J, Geller M. 89.  2016. A BAT deal with Reynolds adds to Big Tobacco's e-cig advantage. Reuters Oct. 26. http://www.reuters.com/article/us-reynolds-amricn-m-a-vape-analysis/a-bat-deal-with-reynolds-adds-to-big-tobaccos-e-cig-advantage-idUSKCN12P2YW [Google Scholar]
  90. Miyashita L, Suri R, Grigg J. 90.  2017. The effect of e-cigarettes (EC) on nasal platelet activating factor receptor (PAFR) expression Abstr. A1029. Presented at Am. Thorac. Soc. 2017 Int. Conf., May 19–24 Washington, DC: http://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2017.195.1_MeetingAbstracts.A1029 [Google Scholar]
  91. Moazed F, Calfee CS. 91.  2017. The canary in the coal mine is coughing: electronic cigarettes and respiratory symptoms in adolescents. Am. J. Respir. Crit. Care Med. 195:974–76 [Google Scholar]
  92. Moheimani RS, Bhetraratana M, Yin F, Peters KM, Gornbein J. 92.  et al. 2017. Increased cardiac sympathetic activity and oxidative stress in habitual electronic cigarette users: implications for cardiovascular risk. JAMA Cardiol 2:278–84 [Google Scholar]
  93. Moore GF, Littlecott HJ, Moore L, Ahmed N, Holliday J. 93.  2014. E-cigarette use and intentions to smoke among 10–11-year-old never-smokers in Wales. Tob. Control 25:147–52 [Google Scholar]
  94. Moretto N, Volpi G, Pastore F, Facchinetti F. 94.  2012. Acrolein effects in pulmonary cells: relevance to chronic obstructive pulmonary disease. Ann. N. Y. Acad. Sci. 1259:39–46 [Google Scholar]
  95. Nagelhout GE, Levy DT, Blackman K, Currie L, Clancy L, Willemsen MC. 95.  2012. The effect of tobacco control policies on smoking prevalence and smoking-attributable deaths. Findings from the Netherlands SimSmoke Tobacco Control Policy Simulation Model. Addiction 107:407–16 [Google Scholar]
  96. 96. Natl. Health Serv. 2017. Smokefree NHS: electronic cigarettes Natl. Health Serv London: https://www.nhs.uk/smokefree/help-and-advice/e-cigarettes [Google Scholar]
  97. Nutt DJ, Phillips LD, Balfour D, Curran HV, Dockrell M. 97.  et al. 2014. Estimating the harms of nicotine-containing products using the MCDA approach. Eur. Addict. Res. 20:218–25 [Google Scholar]
  98. Ogunwale MA, Li M, Ramakrishnam Raju MV, Chen Y, Nantz MH. 98.  et al. 2017. Aldehyde detection in electronic cigarette aerosols. ACS Omega 2:1207–14 [Google Scholar]
  99. Patel D, Davis KC, Cox S, Bradfield B, King BA. 99.  et al. 2016. Reasons for current E-cigarette use among U.S. adults. Prev. Med. 93:14–20 [Google Scholar]
  100. Pearson JL, Stanton CA, Cha S, Niaura RS, Luta G, Graham AL. 100.  2015. E-cigarettes and smoking cessation: insights and cautions from a secondary analysis of data from a study of online treatment-seeking smokers. Nicotine Tob. Res. 17:1219–27 [Google Scholar]
  101. Pope CA 3rd, Burnett RT, Krewski D, Jerrett M, Shi Y. 101.  et al. 2009. Cardiovascular mortality and exposure to airborne fine particulate matter and cigarette smoke: shape of the exposure-response relationship. Circulation 120:941–48 [Google Scholar]
  102. Primack BA, Shensa A, Sidani JE, Hoffman BL, Soneji S. 102.  et al. 2016. Initiation of cigarette smoking after e-cigarette use: a nationally representative study. Presented at Annu. Meet. Sci. Sess. Soc. Behav. Med., 37th, March 30–April 2 Washington, DC:
  103. Primack BA, Soneji S, Stoolmiller M, Fine MJ, Sargent JD. 103.  2015. Progression to traditional cigarette smoking after electronic cigarette use among US adolescents and young adults. JAMA Pediatr 169:1018–23 [Google Scholar]
  104. Prochaska JJ, Grana RA. 104.  2014. E-cigarette use among smokers with serious mental illness. PLOS ONE 9:e113013 [Google Scholar]
  105. 105. R. Coll. Phys. 2016. Nicotine Without Smoke: Tobacco Harm Reduction London: R. Coll. Phys. [Google Scholar]
  106. 106. R. Soc. Public Health. 2016. Growing consensus on the harm-reduction potential of e-cigarettes April 28. R. Soc. Public Health, London [Google Scholar]
  107. Rahman MA, Hann N, Wilson A, Mnatzaganian G, Worrall-Carter L. 107.  2015. E-cigarettes and smoking cessation: evidence from a systematic review and meta-analysis. PLOS ONE 10:e0122544 [Google Scholar]
  108. 108. Reuters. 2015. Teen e-cigarette use triples, but cigarette smoking falls. New York Daily News April 17. http://www.nydailynews.com/life-style/health/teen-e-cigarette-triples-cigarette-smoking-falls-article-1.2188748 [Google Scholar]
  109. Roditis M, Delucchi K, Cash D, Halpern-Felsher B. 109.  2016. Adolescents’ perceptions of health risks, social risks, and benefits differ across tobacco products. J. Adolesc. Health 58:558–66 [Google Scholar]
  110. Roditis ML, Halpern-Felsher B. 110.  2015. Adolescents’ perceptions of risks and benefits of conventional cigarettes, e-cigarettes, and marijuana: a qualitative analysis. J. Adolesc. Health 57:179–85 [Google Scholar]
  111. Rodu B. 111.  2016. This caused smoking to drop 10% in a year; why isn't the CDC cheering? July 8. Am. Counc. Sci. Health, New York. https://www.acsh.org/news/2016/07/08/harm-reduction-caused-smoking-to-drop-10-in-a-year-why-isnt-the-cdc-cheering [Google Scholar]
  112. Schober W, Szendrei K, Matzen W, Osiander-Fuchs H, Heitmann D. 112.  et al. 2014. Use of electronic cigarettes (e-cigarettes) impairs indoor air quality and increases FeNO levels of e-cigarette consumers. Int. J. Hyg. Environ. Health 217:628–37 [Google Scholar]
  113. Schweitzer RJ, Wills TA, Behner D. 113.  2017. E-cigarette use and indicators of cardiovascular disease risk. Curr. Epid. Rep. 4:248–57 [Google Scholar]
  114. Shahab L, Goniewicz ML, Blount BC, Brown J, McNeill A. 114.  et al. 2017. Nicotine, carcinogen, and toxin exposure in long-term e-cigarette and nicotine replacement therapy users: a cross-sectional study. Ann. Intern. Med. 166:390–400 [Google Scholar]
  115. Shi Y, Pierce J, White M, Compton W, Conway K. 115.  et al. 2015. E-cigarette use, smoking cessation, and change in smoking intensity in 2010/2011 TUS-CPS longitudinal cohort Presented at Annu. Meet. Soc. Res. Nicotine Tob., 21st, Feb. 25–28, Phila. [Google Scholar]
  116. Simonavicius E, McNeill A, Arnott D, Brose LS. 116.  2017. What factors are associated with current smokers using or stopping e-cigarette use?. Drug Alcohol Depend 173:139–43 [Google Scholar]
  117. Singh T, Arrazola RA, Corey CG, Husten CG, Neff LJ. 117.  et al. 2016. Tobacco use among middle and high school students–United States, 2011–2015. MMWR 65:361–67 [Google Scholar]
  118. 118. Smok. in Pregnancy Chall. Group. 2016. Use of electronic cigarettes in pregnancy: a guide for midwives and other healthcare professionals Brief, June. http://www.smokefreeaction.org.uk/SIP/files/eCigSIP.pdf [Google Scholar]
  119. Soneji S, Barrington-Trimis JL, Wills TA, Leventhal A, Unger JB. 119.  et al. 2017. Association between initial use of e-cigarettes and subsequent cigarette smoking among adolescents and young adults: a systematic review and meta-analysis. JAMA Pediatr 171:788–97 [Google Scholar]
  120. Soule EK, Maloney SF, Spindle TR, Rudy AK, Hiler MM, Cobb CO. 120.  2017. Electronic cigarette use and indoor air quality in a natural setting. Tob. Control 26:109–12 [Google Scholar]
  121. Spindle TR, Hiler MM, Cooke ME, Eissenberg T, Kendler KS, Dick DM. 121.  2017. Electronic cigarette use and uptake of cigarette smoking: a longitudinal examination of U.S. college students. Addict. Behav. 67:66–72 [Google Scholar]
  122. Stimson GV, Thom B, Costall P. 122.  2014. Disruptive innovations: the rise of the electronic cigarette. Int. J. Drug Policy 25:653–55 [Google Scholar]
  123. Sullum J. 123.  2013. CDC belatedly reveals that smoking by teenagers dropped while vaping rose. Forbes Nov. 20. https://www.forbes.com/sites/jacobsullum/2013/11/20/cdc-belatedly-reveals-that-smoking-by-teenagers-dropped-while-vaping-rose/#71b5e113698b [Google Scholar]
  124. Sutfin EL, Reboussin BA, Debinski B, Wagoner KG, Spangler J, Wolfson M. 124.  2015. The impact of trying electronic cigarettes on cigarette smoking by college students: a prospective analysis. Am. J. Public Health 105:e83–89 [Google Scholar]
  125. Talal A, Pena I, Temesgen N, Glantz SA. 125.  2018. Association between electronic cigarette use and myocardial infarction: results from the 2014 and 2016 National Health Interview Surveys. Presented at Annu. Meet. Res. Nicotine Tob., 24th, Baltimore, MD.
  126. Targonski PV, Bonetti PO, Pumper GM, Higano ST, Holmes DR Jr, Lerman A. 126.  2003. Coronary endothelial dysfunction is associated with an increased risk of cerebrovascular events. Circulation 107:2805–9 [Google Scholar]
  127. 127. TobaccoTactics. 2016. Delon Human Updated Oct. 19, Univ. Bath, Bath, UK. http://www.tobaccotactics.org/index.php/Delon_Human [Google Scholar]
  128. 128. TobaccoTactics. 2016. E-cigarettes Updated July 5, Univ. Bath, Bath, UK. http://www.tobaccotactics.org/index.php/E-cigarettes [Google Scholar]
  129. 129. TobaccoTactics.org. 2016. Riccardo Polosa Updated July 7, Univ. Bath, Bath, UK. http://www.tobaccotactics.org/index.php/Riccardo_Polosa [Google Scholar]
  130. 130. Truth Initiat. 2015. The truth about: electronic nicotine delivery systems Brief, Dec., Truth Initiat Washington, DC: https://truthinitiative.org/sites/default/files/The_Truth_About_Electronic_Nicotine_Delivery_Systems.pdf [Google Scholar]
  131. 131. UK Off. Natl. Stat. 2016. Adult smoking habits in Great Britain: 2014 Stat. Bull., Off. Natl. Stat Newport, UK: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/healthandlifeexpectancies/bulletins/adultsmokinghabitsingreatbritain/2016 [Google Scholar]
  132. Ulucanlar S, Fooks GJ, Gilmore AB. 132.  2016. The policy dystopia model: an interpretive analysis of tobacco industry political activity. PLOS Med 13:e1002125 [Google Scholar]
  133. Unger JB, Soto DW, Leventhal A. 133.  2016. E-cigarette use and subsequent cigarette and marijuana use among Hispanic young adults. Drug Alcohol Depend 163:261–64 [Google Scholar]
  134. 134. US DHHS (Dep. Health Hum. Serv.). 2014. The Health Consequences of Smoking—50 Years of Progress. A Report of the Surgeon General. Rockville, MD: US DHHS, Public Health Serv. Off. Surg. Gen https://www.surgeongeneral.gov/library/reports/50-years-of-progress/full-report.pdf [Google Scholar]
  135. 135. US DHHS (Dep. Health Hum. Serv.). 2014. The Health Consequences of Smoking—50 Years of Progress. A Report of the Surgeon General. Executive Summary. Rockville, MD: US DHHS, Public Health Serv. Off. Surg. Gen. [Google Scholar]
  136. 136. US DHHS (Dep. Health Hum. Serv.). 2016. E-Cigarette Use Among Youth and Young Adults. A Report of the Surgeon General. Atlanta: Cent. Dis. Control Prev., Natl. Cent. Chronic Dis. Prev. Health Promot, Off. Smok. Health https://e-cigarettes.surgeongeneral.gov/documents/2016_SGR_Full_Report_non-508.pdf [Google Scholar]
  137. 137. US EPA (Environ. Prot. Agency). 2016. NAAQS table Updated Dec. 20, US EPA Washington, DC: https://www.epa.gov/criteria-air-pollutants/naaqs-table [Google Scholar]
  138. Vickerman KA, Carpenter KM, Altman T, Nash CM, Zbikowski SM. 138.  2013. Use of electronic cigarettes among state tobacco cessation quitline callers. Nicotine Tob. Res. 15:1787–91 [Google Scholar]
  139. Wang TW, Kenemer B, Tynan MA, Singh T, King B. 139.  2016. Consumption of combustible and smokeless tobacco—United States, 2000–2015. MMWR 65:1357–63 [Google Scholar]
  140. 140. WHO (World Health Organ.). 2016. Electronic Nicotine Delivery Systems and Electronic Non-Nicotine Delivery Systems (ENDS/ENNDS) Rep. FCTC/COP/7/11, WHO, Geneva. http://www.who.int/fctc/cop/cop7/FCTC_COP_7_11_EN.pdf [Google Scholar]
  141. Widlansky ME, Gokce N, Keaney JF Jr, Vita JA. 141.  2003. The clinical implications of endothelial dysfunction. J. Am. Coll. Cardiol. 42:1149–60 [Google Scholar]
  142. Wills TA, Gibbons FX, Sargent JD, Schweitzer RJ. 142.  2016. How is the effect of adolescent e-cigarette use on smoking onset mediated: a longitudinal analysis. Psychol. Addict. Behav. 30:876–86 [Google Scholar]
  143. Wills TA, Knight R, Williams RJ, Pagano I, Sargen JD. 143.  2015. Risk factors for exclusive e-cigarette use and dual e-cigarette use and tobacco use in adolescents. Pediatrics 135:e43–51 [Google Scholar]
  144. Woodruff TJ, Rosbrook B, Pierce J, Glantz SA. 144.  1993. Lower levels of cigarette consumption found in smoke-free workplaces in California. Arch. Intern. Med. 153:1485–93 [Google Scholar]
  145. Yeboah J, Folsom AR, Burke GL, Johnson C, Polak JF. 145.  et al. 2009. Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the multi-ethnic study of atherosclerosis. Circulation 120:502–9 [Google Scholar]
  146. Yeboah J, Sutton-Tyrrell K, McBurnie MA, Burke GL, Herrington DM, Crouse JR. 146.  2008. Association between brachial artery reactivity and cardiovascular disease status in an elderly cohort: the cardiovascular health study. Atherosclerosis 197:768–76 [Google Scholar]
  147. Yong H-H, Hitchman SC, Cummings KM, Borland R, Gravely SML. 147.  et al. 2017. Does the regulatory environment for e-cigarettes influence the effectiveness of e-cigarettes for smoking cessation?: Longitudinal findings from the ITC Four Country Survey. Nicotine Tob. Res. https://doi.org/10.1093/ntr/ntx056 [Crossref] [Google Scholar]
  148. Zablocki RW, Edland SD, Myers MG, Strong DR, Hofstetter CR, Al-Delaimy WK. 148.  2014. Smoking ban policies and their influence on smoking behaviors among current California smokers: a population-based study. Prev. Med. 59:73–78 [Google Scholar]
  149. Zawertailo L, Pavlov D, Ivanova A, Ng G, Baliunas D, Selby P. 149.  2017. Concurrent e-cigarette use during tobacco dependence treatment in primary care settings: association with smoking cessation at three and six months. Nicotine Tob. Res. 19:183–89 [Google Scholar]
  150. Zhu S-H, Sun JY, Bonnevie E, Cummins SE, Gamst A. 150.  et al. 2014. Four hundred and sixty brands of e-cigarettes and counting: implications for product regulation. Tob. Control 23:Suppl. 3iii3–9 [Google Scholar]
  151. Zhuang YL, Cummins SE, Sun JY, Zhu S-H. 151.  2016. Long-term e-cigarette use and smoking cessation: a longitudinal study with US population. Tob. Control 25:i90–95 [Google Scholar]

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