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Annual Review of Virology

Volume 8, 2021

I Am Here: It Took a Global Village

Abstract

The saying “It takes a village to raise a child” has never been truer than in my case. This autobiographical article documents my growing up and working on three different continents and my influencers along the way. Born in a village in Nigeria, West Africa, I spent the first 12 years of life with my grandmother living in a mud house and attending a village primary school. I walked barefoot to school every day, learned to read, and wrote on a chalk slate. At the age of 13, I moved to my second “village,” London, England. In secondary school my love of science began to blossom. I attained a double major in chemistry and human biology from the University of Hertfordshire and a PhD in biophysics from the University of London, with a research project aimed at designing anticancer agents. I was mentored by Terence Jenkins and Stephen Neidle. For my postdoctoral training, I crossed the ocean again, to the United States, my third “village.” In Michael Rossmann's group at Purdue University, my love for viruses was ignited. My independent career in structural virology began at Warwick University, England, working on pathogenic single-stranded DNA packaging viruses. In 2020, I am a full professor at the University of Florida. Most of my research is focused on the adeno-associated viruses, gene delivery vectors. My list of mentors has grown and includes Nick Muzyczka. Here, the mentee has become the mentor, and along the way, we attained a number of firsts in the field of structural virology and contributed to the field at the national and international stages.

Keyword(s): AAV, African woman, autobiography, Mavis Agbandje, ssDNA viruses, structural biology
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2021-09-29
2024-05-13
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Literature Cited

  1. 1. 
    Abraham ZH, Agbandje M, Neidle S, Acheson RM 1988. Experimental DNA-binding and computer modelling studies on an analogue of the anti-tumor drug amsacrine. J. Biomol. Struct. Dyn. 6:471–88
     [Google Scholar]
  2. 2. 
    Agbandje M, Jenkins TC, McKenna R, Reszka AP, Neidle S 1992. Anthracene-9,10-diones as potential anticancer agents. Synthesis, DNA-binding, and biological studies on a series of 2,6-disubstituted derivatives. J. Med. Chem. 35:1418–29
     [Google Scholar]
  3. 3. 
    McKenna R, Agbandje M, Neidle S 1992. Structure of 9-amino-2,7-di-tert-butylacridine. Acta Crystallogr. C 48:188–90
     [Google Scholar]
  4. 4. 
    Neidle S, Agbandje M, Jenkins TC, McConnaughie AW 1990. Structure and conformational features of 9-(4-diethylaminophenyl)acridine. Acta Crystallogr. B 46:860–62
     [Google Scholar]
  5. 5. 
    Venitt S, Crofton-Sleigh C, Agbandje M, Jenkins TC, Neidle S 1998. Anthracene-9,10-diones as potential anticancer agents: bacterial mutation studies of amido-substituted derivatives reveal an unexpected lack of mutagenicity. J. Med. Chem. 41:3748–52
     [Google Scholar]
  6. 6. 
    Mietzsch M, Agbandje-McKenna M. 2017. The good that viruses do. Annu. Rev. Virol. 4:iii–v
     [Google Scholar]
  7. 7. 
    Luo M, Tsao J, Rossmann MG, Basak S, Compans RW 1988. Preliminary X-ray crystallographic analysis of canine parvovirus crystals. J. Mol. Biol. 200:209–11
     [Google Scholar]
  8. 8. 
    Tsao J, Chapman MS, Agbandje M, Keller W, Smith K et al. 1991. The three-dimensional structure of canine parvovirus and its functional implications. Science 251:1456–64
     [Google Scholar]
  9. 9. 
    Tsao J, Chapman MS, Wu H, Agbandje M, Keller W, Rossmann MG 1992. Structure determination of monoclinic canine parvovirus. Acta Crystallogr. B 48:Part 175–88
     [Google Scholar]
  10. 10. 
    Agbandje M, McKenna R, Rossmann MG, Strassheim ML, Parrish CR 1993. Structure determination of feline panleukopenia virus empty particles. Proteins 16:155–71
     [Google Scholar]
  11. 11. 
    Agbandje M, McKenna R, Rossmann MG, Kajigaya S, Young NS 1991. Preliminary X-ray crystallographic investigation of human parvovirus B19. Virology 184:170–74
     [Google Scholar]
  12. 12. 
    Agbandje M, Kajigaya S, McKenna R, Young NS, Rossmann MG 1994. The structure of human parvovirus B19 at 8 Å resolution. Virology 203:106–15
     [Google Scholar]
  13. 13. 
    Chipman PR, Agbandje-McKenna M, Kajigaya S, Brown KE, Young NS et al. 1996. Cryo-electron microscopy studies of empty capsids of human parvovirus B19 complexed with its cellular receptor. PNAS 93:7502–6
     [Google Scholar]
  14. 14. 
    Llamas-Saiz AL, Agbandje-McKenna M, Wikoff WR, Bratton J, Tattersall P, Rossmann MG 1997. Structure determination of minute virus of mice. Acta Crystallogr. D 53:93–102
     [Google Scholar]
  15. 15. 
    Agbandje-McKenna M, Llamas-Saiz AL, Wang F, Tattersall P, Rossmann MG 1998. Functional implications of the structure of the murine parvovirus, minute virus of mice. Structure 6:1369–81
     [Google Scholar]
  16. 16. 
    Govindasamy L, Hueffer K, Parrish CR, Agbandje-McKenna M 2003. Structures of host range-controlling regions of the capsids of canine and feline parvoviruses and mutants. J. Virol. 77:12211–21
     [Google Scholar]
  17. 17. 
    Kontou M, Govindasamy L, Nam HJ, Bryant N, Llamas-Saiz AL et al. 2005. Structural determinants of tissue tropism and in vivo pathogenicity for the parvovirus minute virus of mice. J. Virol. 79:10931–43
     [Google Scholar]
  18. 18. 
    McKenna R, Olson NH, Chipman PR, Baker TS, Booth TF et al. 1999. Three-dimensional structure of Aleutian mink disease parvovirus: implications for disease pathogenicity. J. Virol. 73:6882–91
     [Google Scholar]
  19. 19. 
    Bloom ME, Martin DA, Oie KL, Huhtanen ME, Costello F et al. 1997. Expression of Aleutian mink disease parvovirus capsid proteins in defined segments: localization of immunoreactive sites and neutralizing epitopes to specific regions. J. Virol. 71:705–14
     [Google Scholar]
  20. 20. 
    Ilyas M, Mietzsch M, Kailasan S, Vaisanen E, Luo M et al. 2018. Atomic resolution structures of human bufaviruses determined by cryo-electron microscopy. Viruses 10:22
     [Google Scholar]
  21. 21. 
    Mietzsch M, Kailasan S, Garrison J, Ilyas M, Chipman P et al. 2017. Structural insights into human bocaparvoviruses. J. Virol. 91:e00261-17
     [Google Scholar]
  22. 22. 
    Govindasamy L, Padron E, McKenna R, Muzyczka N, Kaludov N et al. 2006. Structurally mapping the diverse phenotype of adeno-associated virus serotype 4. J. Virol. 80:11556–70
     [Google Scholar]
  23. 23. 
    DiMattia MA, Nam HJ, Van Vliet K, Mitchell M, Bennett A et al. 2012. Structural insight into the unique properties of adeno-associated virus serotype 9. J. Virol. 86:6947–58
     [Google Scholar]
  24. 24. 
    Mietzsch M, Barnes C, Hull JA, Chipman P, Xie J et al. 2020. Comparative analysis of the capsid structures of AAVrh.10, AAVrh.39, and AAV8. J. Virol. 94:e01769-19
     [Google Scholar]
  25. 25. 
    Am. Soc. Microbiol 2012. Researchers determine 3D structure of adeno-associated virus 9: aim to boost gene therapy Press Release, June 21. http://medicalxpress.com/news/2012-06-3d-adeno-associated-virus-aim-boost.html
  26. 26. 
    McKenna R, Xia D, Willingmann P, Ilag LL, Krishnaswamy S et al. 1992. Atomic structure of single-stranded DNA bacteriophage ΦX174 and its functional implications. Nature 355:137–43
     [Google Scholar]
  27. 27. 
    Zhang W, Olson NH, Baker TS, Faulkner L, Agbandje-McKenna M et al. 2001. Structure of the Maize streak virus geminate particle. Virology 279:471–77
     [Google Scholar]
  28. 28. 
    Lopez-Bueno A, Rubio MP, Bryant N, McKenna R, Agbandje-McKenna M, Almendral JM 2006. Host-selected amino acid changes at the sialic acid binding pocket of the parvovirus capsid modulate cell binding affinity and determine virulence. J. Virol. 80:1563–73
     [Google Scholar]
  29. 29. 
    Nam HJ, Gurda BL, McKenna R, Potter M, Byrne B et al. 2011. Structural studies of adeno-associated virus serotype 8 capsid transitions associated with endosomal trafficking. J. Virol. 85:11791–99
     [Google Scholar]
  30. 30. 
    Tan YZ, Aiyer S, Mietzsch M, Hull JA, McKenna R et al. 2018. Sub-2 Å Ewald curvature corrected structure of an AAV2 capsid variant. Nat. Commun. 9:3628
     [Google Scholar]
  31. 31. 
    Jose A, Mietzsch M, Smith JK, Kurian J, Chipman P et al. 2019. High-resolution structural characterization of a new adeno-associated virus serotype 5 antibody epitope toward engineering antibody-resistant recombinant gene delivery vectors. J. Virol. 93:e01394-18
     [Google Scholar]
  32. 32. 
    Bowles DE, McPhee SW, Li C, Gray SJ, Samulski JJ et al. 2012. Phase 1 gene therapy for Duchenne muscular dystrophy using a translational optimized AAV vector. Mol. Ther. 20:443–55
     [Google Scholar]
  33. 33. 
    Burg M, Rosebrough C, Drouin LM, Bennett A, Mietzsch M et al. 2018. Atomic structure of a rationally engineered gene delivery vector, AAV2.5. J. Struct. Biol. 203:236–41
     [Google Scholar]
  34. 34. 
    Zhong L, Li B, Mah CS, Govindasamy L, Agbandje-McKenna M et al. 2008. Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses. PNAS 105:7827–32
     [Google Scholar]
  35. 35. 
    Zhong L, Li B, Jayandharan G, Mah CS, Govindasamy L et al. 2008. Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression. Virology 381:194–202
     [Google Scholar]
  36. 36. 
    Tse LV, Klinc KA, Madigan VJ, Castellanos Rivera RM, Wells LF et al. 2017. Structure-guided evolution of antigenically distinct adeno-associated virus variants for immune evasion. PNAS 114:E4812–21
     [Google Scholar]
  37. 37. 
    Chun D. 2005. Mavis Agbandje-Mckenna, 41. Gainesville Magazine, Apr. 6. https://www.gainesville.com/article/LK/20050406/news/604157599/GS
  38. 38. 
    Zapp Machalek A. 2006. Viral voyages. Findings, March. https://www.nigms.nih.gov/education/findings/Documents/FindingsMagazine-2006March.pdf#page=10
  39. 39. 
    Pastor J. 2010. The sweet science: viruses switch grip to gain upper hand. The Post Oct. https://podcasts.ufhealth.org/files/2010/01/ThePost_OCT06.pdf
    [Google Scholar]
  40. 40. 
    Univ. Florida 2016. Research Landscapes: Mavis Agbandje-McKenna, Ph.D. https://www.youtube.com/watch?v=kBdRstLimSI
  41. 41. 
    This Week in Virology 2017. TWiV 448: Mavis the structure maven. This Week in Virology http://www.microbe.tv/twiv/twiv-448/
    [Google Scholar]
  42. 42. 
    Univ. Florida 2018. 2018 UF Innovator of the Year—Dr. Mavis Agbandje-McKenna. University of Florida https://biochem.med.ufl.edu/2018/09/28/2018-uf-innovator-of-the-year-dr-mavis-agbandje-mckenna/
    [Google Scholar]
  43. 43. 
    Am. Soc. Gene Cell Ther 2020. Congratulations to the 2020 ASGCT Award winners. American Society of Gene & Cell Therapy https://www.asgct.org/research/news/april-2020/2020-award-winners
    [Google Scholar]
/content/journals/10.1146/annurev-virology-091919-104940
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I Am Here: It Took a Global Village
Annual Review of Virology 8, 1 (2021); https://doi.org/10.1146/annurev-virology-091919-104940
/content/journals/10.1146/annurev-virology-091919-104940
/content/journals/10.1146/annurev-virology-091919-104940
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