1932

Abstract

I was shaped by World War II, years of near starvation as a war refugee, postwar chaos, life in several countries, and relative affluence in later life. The truth is that as I was growing up I wanted to be a writer. My aspirations came to an end when, in order to speed up my graduation from college, I took courses in microbiology. It was my second love at first sight—that of my wife preceded it. I view science as an opportunity to discover the designs in the mosaics of life. What initiates my search of discovery is an observation that makes no sense unless there exists a novel design. Once the design is revealed there is little interest in filling all the gaps. I was fortunate to understand that what lasts are not the scientific reports but rather the generations of scientists whose education I may have influenced.

Loading

Article metrics loading...

/content/journals/10.1146/annurev-virology-100114-054829
2015-11-09
2024-06-23
Loading full text...

Full text loading...

/deliver/fulltext/virology/2/1/annurev-virology-100114-054829.html?itemId=/content/journals/10.1146/annurev-virology-100114-054829&mimeType=html&fmt=ahah

Literature Cited

  1. Spear PG, Roizman B. 1.  1972. Proteins specified by herpes simplex virus. V. Purification and structural proteins of the herpesvirion. J. Virol. 9:143–59 [Google Scholar]
  2. Gibson W, Roizman B. 2.  1972. Proteins specified by herpes simplex virus. VIII. Characterization and composition of multiple capsid forms of subtypes 1 and 2. J. Virol. 10:1044–52 [Google Scholar]
  3. Gibson W, Roizman B. 3.  1971. Compartmentalization of spermine and spermidine in the herpes simplex virion. PNAS 68:2818–21 [Google Scholar]
  4. Liu F, Roizman B. 4.  1991. The herpes simplex virus 1 gene encoding a protease also contains within its coding domain the gene encoding the more abundant substrate. J. Virol. 65:5149–56 [Google Scholar]
  5. Honess RW, Roizman B. 5.  1973. Proteins specified by herpes simplex virus. XI. Identification and relative molar rates of synthesis of structural and non-structural herpesvirus polypeptides in the infected cell. J. Virol. 12:1346–65 [Google Scholar]
  6. Honess RW, Roizman B. 6.  1974. Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins. J. Virol. 14:8–19 [Google Scholar]
  7. Mackem S, Roizman B. 7.  1982. Structural features of the herpes simplex virus α gene 4, 0, and 27 promoter-regulatory sequences which confer α regulation on chimeric thymidine kinase genes. J. Virol. 44:939–49 [Google Scholar]
  8. Batterson W, Roizman B. 8.  1983. Characterization of the herpes simplex virion-associated factor responsible for the induction of α genes. J. Virol. 46:371–77 [Google Scholar]
  9. Kristie TM, Roizman B. 9.  1984. Separation of sequences defining basal expression from those conferring α gene recognition within the regulatory domains of herpes simplex virus 1 α genes. PNAS 81:4065–69 [Google Scholar]
  10. Kristie TM, Roizman B. 10.  1987. Host cell proteins bind to the cis-acting site required for virion-mediated induction of herpes simplex virus 1 α genes. PNAS 84:71–75 [Google Scholar]
  11. McKnight JLC, Kristie TM, Roizman B. 11.  1987. Binding of the virion protein mediating α gene induction in herpes simplex virus 1 infected cells to its cis site requires cellular proteins. PNAS 84:7061–65 [Google Scholar]
  12. Pellett PE, McKnight JLC, Jenkins FJ, Roizman B. 12.  1985. Nucleotide sequence and predicted amino acid sequence of a protein encoded in a small herpes simplex virus DNA fragment capable of trans-inducing α genes. PNAS 82:5870–74 [Google Scholar]
  13. Roizman B, Furlong D. 13.  1974. The replication of herpesviruses. Comprehensive Virology 3 H Fraenkel-Conrat, RR Wagner 229–403 New York: Plenum [Google Scholar]
  14. Knipe DM, Lieberman PM, Jung JJ, McBride AA, Morris KV. 14.  et al. 2013. Snapshot: chromatin control of viral infections. Virology 435:141–56 [Google Scholar]
  15. Kalamvoki M, Roizman B. 15.  2010. The role of herpes simplex virus ICP0 in the transactivation of genes introduced by infection or transfection: a reappraisal. J. Virol. 84:4222–28 [Google Scholar]
  16. Gu H, Liang Y, Mandel G, Roizman B. 16.  2005. Components of the REST/CoREST/HDAC repressor are disrupted, modified and translocated in herpes simplex virus 1 infected cells. PNAS 102:5771–76 [Google Scholar]
  17. Chee AV, Lopez P, Pandolfi PP, Roizman B. 17.  2003. Promyelocytic leukemia protein mediates interferon-based anti-herpes simplex virus 1 effects. J. Virol. 77:7101–5 [Google Scholar]
  18. Gu H, Roizman B. 18.  2007. Herpes simplex virus ICP0 blocks the silencing of viral DNA by dissociating HDACs from the CoREST/REST complex. PNAS 104:17134–39 [Google Scholar]
  19. Du T, Zhou G, Roizman B. 19.  2011. HSV-1 gene expression from reactivated ganglia is disordered and concurrent with suppression of latency associated transcript and miRNAs. PNAS 108:18820–24 [Google Scholar]
  20. Du T, Zhou G, Roizman B. 20.  2013. Modulation of reactivation of latent herpes simplex virus 1 in ganglionic organ cultures by p300/CBP and STAT3. PNAS 10:E2621–28 [Google Scholar]
  21. Zhou G, Du T, Roizman B. 21.  2010. The CoREST/REST repressor is both necessary and inimical for expression of herpes simplex virus genes. mBio 2:e00313–10 [Google Scholar]
  22. Du T, Zhou G, Khan S, Gu H, Roizman B. 22.  2010. Disruption of HDAC/CoREST/REST repressor by dnREST reduces genome silencing and increases virulence of herpes simplex virus. PNAS 107:15904–9 [Google Scholar]
  23. Pereira L, Cassai E, Honess RW, Roizman B, Terni M, Nahmias A. 23.  1976. Variability in the structural polypeptides of herpes simplex virus 1 strains: potential applications in molecular epidemiology. Infect. Immun. 13:211–20 [Google Scholar]
  24. Buchman TG, Roizman B, Adams G, Stover H. 24.  1978. Restriction endonuclease fingerprinting of herpes simplex virus DNA: a novel epidemiological tool applied to a nosocomial outbreak. J. Infect. Dis. 138:488–98 [Google Scholar]
  25. Linnemann CC Jr, Buchman TG, Light IJ, Ballard JL, Roizman B. 25.  1978. Transmission of herpes-simplex virus type 1 in a nursery for the newborn: identification of viral isolates by DNA “fingerprinting.”. Lancet 1:964–66 [Google Scholar]
  26. Adams G, Stoves BH, Keenlyside RA, Hooton TM, Buchman TG. 26.  et al. 1981. Nosocomial herpetic infection in a pediatric intensive care unit. Am. J. Epidemiol. 113:126–32 [Google Scholar]
  27. Whitley R, Lakeman AD, Nahmias A, Roizman B. 27.  1982. DNA restriction analysis of herpes simplex virus isolates obtained from patients with encephalitis. N. Engl. J. Med. 307:1060–62 [Google Scholar]
  28. Ejercito PM, Kieff ED, Roizman B. 28.  1968. Characterization of herpes simplex virus strains differing in their effect on social behavior of infected cells. J. Gen. Virol. 2:357–64 [Google Scholar]
  29. Post LE, Roizman B. 29.  1981. A generalized technique for deletion of specific genes in large genomes: α gene 22 of herpes simplex virus 1 is not essential for growth. Cell 25:227–32 [Google Scholar]
/content/journals/10.1146/annurev-virology-100114-054829
Loading
/content/journals/10.1146/annurev-virology-100114-054829
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error