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Annual Review of Virology

Volume 2, 2015

Modulation of the Translational Landscape During Herpesvirus Infection

Abstract

Herpesviral mRNAs are produced and translated by cellular machinery, rendering them susceptible to the network of regulatory events that impact translation. In response, these viruses have evolved to infiltrate and hijack translational control pathways as well as to integrate specialized host translation strategies into their own repertoire. They are robust systems to dissect mechanisms of mammalian translational regulation and continue to offer insight into -acting mRNA features that impact assembly and activity of the translation apparatus. Here, I discuss recent advances revealing the extent to which the three herpesvirus subfamilies regulate both host and viral translation, thereby dramatically impacting the landscape of protein synthesis in infected cells.

Keyword(s): eIF4F, herpesvirus, protein kinase R, translation, unfolded protein response, uORF
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/content/journals/10.1146/annurev-virology-100114-054839
2015-11-09
2025-04-28
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Modulation of the Translational Landscape During Herpesvirus Infection
Annual Review of Virology 2, 311 (2015); https://doi.org/10.1146/annurev-virology-100114-054839
/content/journals/10.1146/annurev-virology-100114-054839
/content/journals/10.1146/annurev-virology-100114-054839
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  • Article Type: Review Article

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