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Annual Review of Virology

Volume 11, 2024

Controlling Much? Viral Control of Host Chromatin Dynamics

  • Laurel E. Kelnhofer-Millevolte1,2, Edward A. Arnold3, Daniel H. Nguyen4 and Daphne C. Avgousti3,4
  • 1Department of Molecular and Cellular Biology, University of Washington, Seattle, Washington, USA 2Medical Scientist Training Program, University of Washington, Seattle, Washington, USA 3Department of Microbiology, University of Washington, Seattle, Washington, USA 4Human Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA; email: [email protected]
  • Vol. 11:171-191 (Volume publication date September 2024)
  • First published as a Review in Advance on April 29, 2024
  • Copyright © 2024 by the author(s).
    This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See credit lines of images or other third-party material in this article for license information.

Abstract

Viruses are exemplary molecular biologists and have been integral to scientific discovery for generations. It is therefore no surprise that nuclear replicating viruses have evolved to systematically take over host cell function through astoundingly specific nuclear and chromatin hijacking. In this review, we focus on nuclear replicating DNA viruses—herpesviruses and adenoviruses—as key examples of viral invasion in the nucleus. We concentrate on critical features of nuclear architecture, such as chromatin and the nucleolus, to illustrate the complexity of the virus-host battle for resources in the nucleus. We conclude with a discussion of the technological advances that have enabled the discoveries we describe and upcoming steps in this burgeoning field.

Keyword(s): adenovirus, chromatin, herpesvirus, histones, latency, nucleus
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2024-09-26
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/content/journals/10.1146/annurev-virology-100422-011616
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Controlling Much? Viral Control of Host Chromatin Dynamics
Annual Review of Virology 11, 171 (2024); https://doi.org/10.1146/annurev-virology-100422-011616
/content/journals/10.1146/annurev-virology-100422-011616
/content/journals/10.1146/annurev-virology-100422-011616
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